YLR233C / EST1

TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR233C / EST1

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:-4.59|P-value:2.62E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-3.72|P-value:5.87E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.34|P-value:4.59E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:-4.07|P-value:1.79E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:-3.67|P-value:6.97E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.27|P-value:5.69E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.18|P-value:7.64E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.15|P-value:1.34E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.12|P-value:9.43E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.24|P-value:6.42E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-4.44|P-value:4.63E-5 ID:SGTC_1771|Compound:st048882|FD-Score:3.55|P-value:2.21E-4 ID:SGTC_1842|Compound:st055362|FD-Score:-7.17|P-value:5.96E-11 ID:SGTC_2008|Compound:4012253|FD-Score:-3.82|P-value:4.31E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.42|P-value:3.54E-4 ID:SGTC_2225|Compound:6654152|FD-Score:3.21|P-value:6.97E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.64|P-value:7.60E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-3.62|P-value:8.18E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.66|P-value:7.20E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-4.05|P-value:1.94E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.22|P-value:6.88E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-3.73|P-value:5.78E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.27|P-value:5.85E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-3.98|P-value:2.48E-4 ID:SGTC_2812|Compound:7970281|FD-Score:-4.14|P-value:1.39E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.32|P-value:4.88E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.31|P-value:5.03E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-4.54|P-value:3.11E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-3.59|P-value:9.13E-4 ID:SGTC_3161|Compound:9100388|FD-Score:-4.07|P-value:1.82E-4 ID:SGTC_3164|Compound:9100705|FD-Score:-4.25|P-value:9.40E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:-4.59|P-value:2.62E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-3.72|P-value:5.87E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.34|P-value:4.59E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:-4.07|P-value:1.79E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:-3.67|P-value:6.97E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.27|P-value:5.69E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.18|P-value:7.64E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.15|P-value:1.34E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.12|P-value:9.43E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.24|P-value:6.42E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-4.44|P-value:4.63E-5 ID:SGTC_1771|Compound:st048882|FD-Score:3.55|P-value:2.21E-4 ID:SGTC_1842|Compound:st055362|FD-Score:-7.17|P-value:5.96E-11 ID:SGTC_2008|Compound:4012253|FD-Score:-3.82|P-value:4.31E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.42|P-value:3.54E-4 ID:SGTC_2225|Compound:6654152|FD-Score:3.21|P-value:6.97E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.64|P-value:7.60E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-3.62|P-value:8.18E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.66|P-value:7.20E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-4.05|P-value:1.94E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.22|P-value:6.88E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-3.73|P-value:5.78E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.27|P-value:5.85E-4 ID:SGTC_2805|Compound:7950783|FD-Score:-3.98|P-value:2.48E-4 ID:SGTC_2812|Compound:7970281|FD-Score:-4.14|P-value:1.39E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.32|P-value:4.88E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.31|P-value:5.03E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-4.54|P-value:3.11E-5 ID:SGTC_3142|Compound:9086498|FD-Score:-3.59|P-value:9.13E-4 ID:SGTC_3161|Compound:9100388|FD-Score:-4.07|P-value:1.82E-4 ID:SGTC_3164|Compound:9100705|FD-Score:-4.25|P-value:9.40E-5

Top fitness defect scores for YLR233C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1771 st048882 3.55 4.2 µM 2.21E-4 RPP1 & pyrimidine depletion 34 1.90E-4
2 SGTC_2013 4024628 3.42 200.0 µM 3.54E-4 66 3.17E-4
3 SGTC_198 3454-2873 3.34 16.2 µM 4.59E-4 60S ribosome export 30 4.20E-4
4 SGTC_2966 9084041 3.32 48.0 µM 4.88E-4 60 4.49E-4
5 SGTC_3114 9122766 3.31 49.5 µM 5.03E-4 37 4.63E-4
6 SGTC_1192 1488-0095 3.27 21.4 µM 5.69E-4 38 5.30E-4
7 SGTC_2801 7907800 3.27 81.8 µM 5.85E-4 58 5.47E-4
8 SGTC_1454 4239-0054 3.24 42.6 µM 6.42E-4 63 6.04E-4
9 SGTC_2571 chrysanthemic acid 3.22 100.0 µM 6.88E-4 50 6.51E-4
10 SGTC_2225 6654152 3.21 15.4 µM 6.97E-4 28 6.60E-4
11 SGTC_1193 1488-0126 3.18 41.5 µM 7.64E-4 49 7.29E-4
12 SGTC_1448 4255-0083 3.12 152.0 µM 9.43E-4 ERG2 49 9.15E-4
13 SGTC_2088 5278280 3.10 127.4 µM 0.00100 66 9.77E-4
14 SGTC_742 0kpi-0133 3.09 140.0 µM 0.00101 ERG2 54 9.89E-4
15 SGTC_943 3253-1379 3.03 105.0 µM 0.00122 59 0.00121
16 SGTC_3001 9076041 3.02 71.4 µM 0.00129 43 0.00128
17 SGTC_2612 dictamnine 2.96 15.5 µM 0.00153 RNA pol III & RNase P/MRP 97 0.00154
18 SGTC_2809 7964133 2.95 13.0 µM 0.00158 60S ribosome export 107 0.00160
19 SGTC_1132 3456-3614 2.91 2.5 µM 0.00175 tubulin folding & SWR complex 125 0.00178
20 SGTC_1210 3013-0140 2.86 750.0 nM 0.00208 46 0.00215

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 4.92E-10 YJR053W BFA1 hom Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis
0.100 6.01E-9 YBR294W SUL1 hom High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.094 4.26E-8 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.091 1.22E-7 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.084 1.25E-6 YKR053C YSR3 hom Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication
0.080 3.14E-6 YPL095C EEB1 hom Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication
0.080 3.35E-6 YGR044C RME1 hom Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.079 4.38E-6 YGR209C TRX2 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.077 8.21E-6 YML027W YOX1 hom Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication
0.073 2.39E-5 YJR031C GEA1 hom Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication
0.070 4.72E-5 YER174C GRX4 hom Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance; transcription is regulated by Yap5
0.069 6.24E-5 YGR149W_p YGR149W_p hom Putative protein of unknown function; predicted to be an integal membrane protein
0.068 7.78E-5 YDR426C_d YDR426C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41
0.066 1.23E-4 YJL030W MAD2 hom Component of the spindle-assembly checkpoint complex; delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I
0.066 1.33E-4 YCR052W RSC6 het Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p