YLR252W_d

Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR252W / YLR252W

Click on Significant Values for Screen Details ID:SGTC_138|Compound:0850-0259|FD-Score:5.12|P-value:4.56E-7 ID:SGTC_245|Compound:methotrexate|FD-Score:4.17|P-value:3.19E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:3.62|P-value:2.61E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:4.32|P-value:1.71E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:3.37|P-value:6.24E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.76|P-value:1.35E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.77|P-value:1.51E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.58|P-value:2.60E-4 ID:SGTC_469|Compound:w7|FD-Score:3.32|P-value:7.40E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.24|P-value:9.80E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.97|P-value:7.04E-5 ID:SGTC_837|Compound:0091-0265|FD-Score:4.07|P-value:4.76E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:3.72|P-value:1.83E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.73|P-value:1.76E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.96|P-value:6.21E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.46|P-value:4.63E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:5.32|P-value:1.67E-7 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.94|P-value:7.96E-5 ID:SGTC_1609|Compound:st001574|FD-Score:-3.55|P-value:2.95E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-4.43|P-value:9.07E-6 ID:SGTC_1647|Compound:st011722|FD-Score:3.38|P-value:6.09E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.85|P-value:1.15E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.04|P-value:5.51E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.43|P-value:4.47E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.97|P-value:7.11E-5 ID:SGTC_1861|Compound:st057647|FD-Score:4.56|P-value:6.26E-6 ID:SGTC_1931|Compound:st074438|FD-Score:-4.20|P-value:2.43E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.18|P-value:3.07E-5 ID:SGTC_2053|Compound:5265679|FD-Score:-3.24|P-value:8.35E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:5.67|P-value:2.59E-8 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.32|P-value:1.75E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.72|P-value:1.58E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:6.08|P-value:2.61E-9 ID:SGTC_3143|Compound:9086658|FD-Score:3.34|P-value:6.96E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-3.40|P-value:4.95E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:5.12|P-value:4.56E-7 ID:SGTC_245|Compound:methotrexate|FD-Score:4.17|P-value:3.19E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:3.62|P-value:2.61E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:4.32|P-value:1.71E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:3.37|P-value:6.24E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.76|P-value:1.35E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.77|P-value:1.51E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.58|P-value:2.60E-4 ID:SGTC_469|Compound:w7|FD-Score:3.32|P-value:7.40E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.24|P-value:9.80E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.97|P-value:7.04E-5 ID:SGTC_837|Compound:0091-0265|FD-Score:4.07|P-value:4.76E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:3.72|P-value:1.83E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.73|P-value:1.76E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.96|P-value:6.21E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.46|P-value:4.63E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:5.32|P-value:1.67E-7 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.94|P-value:7.96E-5 ID:SGTC_1609|Compound:st001574|FD-Score:-3.55|P-value:2.95E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-4.43|P-value:9.07E-6 ID:SGTC_1647|Compound:st011722|FD-Score:3.38|P-value:6.09E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.85|P-value:1.15E-4 ID:SGTC_1745|Compound:st081495|FD-Score:4.04|P-value:5.51E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.43|P-value:4.47E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.97|P-value:7.11E-5 ID:SGTC_1861|Compound:st057647|FD-Score:4.56|P-value:6.26E-6 ID:SGTC_1931|Compound:st074438|FD-Score:-4.20|P-value:2.43E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.18|P-value:3.07E-5 ID:SGTC_2053|Compound:5265679|FD-Score:-3.24|P-value:8.35E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:5.67|P-value:2.59E-8 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.32|P-value:1.75E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.72|P-value:1.58E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:6.08|P-value:2.61E-9 ID:SGTC_3143|Compound:9086658|FD-Score:3.34|P-value:6.96E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-3.40|P-value:4.95E-4

Top fitness defect scores for YLR252W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2777 climbazole 6.08 1.5 µM 2.61E-9 iron homeostasis 10 5.85E-10
2 SGTC_2419 paclitaxel 5.67 166.5 µM 2.59E-8 5 6.97E-9
3 SGTC_1318 1280-3875 5.32 124.0 µM 1.67E-7 6 5.20E-8
4 SGTC_138 0850-0259 5.12 40.9 µM 4.56E-7 cell wall 140 1.54E-7
5 SGTC_1861 st057647 4.56 17.4 µM 6.26E-6 9 2.60E-6
6 SGTC_374 0880-0231 4.32 82.3 µM 1.71E-5 iron homeostasis 16 7.71E-6
7 SGTC_2553 4-methylesculetin 4.32 85.1 µM 1.75E-5 14 7.92E-6
8 SGTC_1951 sophoraflavanone G 4.18 9.2 µM 3.07E-5 RNA processing & uracil transport 16 1.45E-5
9 SGTC_245 methotrexate 4.17 289.6 µM 3.19E-5 41 1.51E-5
10 SGTC_837 0091-0265 4.07 12.5 µM 4.76E-5 ubiquinone biosynthesis & proteasome 21 2.32E-5
11 SGTC_1745 st081495 4.04 74.0 µM 5.51E-5 RNA processing & uracil transport 71 2.72E-5
12 SGTC_795 0685-0265 3.97 78.0 µM 7.04E-5 excess fatty acid 26 3.55E-5
13 SGTC_1803 st050068 3.97 52.4 µM 7.11E-5 NEO1-PIK1 177 3.58E-5
14 SGTC_1350 1495-0454 3.94 146.0 µM 7.96E-5 29 4.05E-5
15 SGTC_1664 st014217 3.85 9.0 µM 1.15E-4 60S ribosome export 11 6.02E-5
16 SGTC_424 splitomicin 3.77 100.0 mM 1.51E-4 25 8.07E-5
17 SGTC_1075 aripiprazole 3.73 15.2 µM 1.76E-4 37 9.54E-5
18 SGTC_1074 carmofur 3.72 3.8 µM 1.83E-4 exosome 27 9.95E-5
19 SGTC_372 0155-0182 3.62 15.9 µM 2.61E-4 mitochondrial response to ROS 37 1.46E-4
20 SGTC_1218 1348-1416 3.46 30.7 µM 4.63E-4 SWF1 & branched chain AA biosynthesis 31 2.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.60E-11 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.112 8.47E-11 YLR420W URA4 hom Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
0.109 2.78E-10 YBL026W LSM2 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.109 2.85E-10 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.107 5.48E-10 YBR156C SLI15 hom Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly
0.102 2.77E-9 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.098 1.29E-8 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
0.098 1.43E-8 YNL271C BNI1 hom Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1
0.097 1.85E-8 YDL071C_d YDL071C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W
0.096 2.40E-8 YPR143W RRP15 het Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
0.093 7.76E-8 YHR030C SLT2 hom Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
0.091 1.30E-7 YOL159C YOL159C hom Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA
0.091 1.49E-7 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.090 1.73E-7 YPR033C HTS1 het Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome
0.090 1.98E-7 YLR426W_p TDA5_p hom Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele