YLR254C / NDL1

Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR254C / NDL1

Click on Significant Values for Screen Details ID:SGTC_107|Compound:0358-0022|FD-Score:-3.13|P-value:5.64E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-2.97|P-value:9.86E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.36|P-value:2.41E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.64|P-value:7.88E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.17|P-value:5.05E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.20|P-value:4.53E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.07|P-value:1.19E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.12|P-value:9.56E-6 ID:SGTC_1032|Compound:k061-1018|FD-Score:5.31|P-value:1.77E-8 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.17|P-value:4.92E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.16|P-value:5.19E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.30|P-value:1.79E-8 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.47|P-value:1.57E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.36|P-value:2.47E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.60|P-value:9.32E-5 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:4.12|P-value:9.26E-6 ID:SGTC_1686|Compound:st019653|FD-Score:3.51|P-value:1.34E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.34|P-value:2.61E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.76|P-value:4.80E-5 ID:SGTC_2205|Compound:7238770|FD-Score:-3.12|P-value:5.76E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.86|P-value:3.10E-5 ID:SGTC_2298|Compound:7976326|FD-Score:-3.00|P-value:8.99E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.13|P-value:5.72E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.10|P-value:6.36E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.78|P-value:4.29E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.02|P-value:8.26E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-4.35|P-value:3.07E-6 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.41|P-value:1.98E-4 ID:SGTC_2821|Compound:7996764|FD-Score:5.71|P-value:1.54E-9 ID:SGTC_2823|Compound:7987624|FD-Score:3.15|P-value:5.39E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.08|P-value:1.11E-5 ID:SGTC_2865|Compound:9030313|FD-Score:3.06|P-value:7.41E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-3.01|P-value:8.80E-4 ID:SGTC_3116|Compound:9124943|FD-Score:-3.22|P-value:4.00E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.52|P-value:1.27E-4 ID:SGTC_3264|Compound:9137442|FD-Score:3.87|P-value:2.93E-5 ID:SGTC_3336|Compound:9143619|FD-Score:3.18|P-value:4.84E-4 ID:SGTC_3344|Compound:9148862|FD-Score:3.49|P-value:1.44E-4 ID:SGTC_3345|Compound:9148410|FD-Score:3.36|P-value:2.40E-4 ID:SGTC_3356|Compound:9151811|FD-Score:-3.34|P-value:2.51E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:-3.13|P-value:5.64E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-2.97|P-value:9.86E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.36|P-value:2.41E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.64|P-value:7.88E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.17|P-value:5.05E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.20|P-value:4.53E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.07|P-value:1.19E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.12|P-value:9.56E-6 ID:SGTC_1032|Compound:k061-1018|FD-Score:5.31|P-value:1.77E-8 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.17|P-value:4.92E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.16|P-value:5.19E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.30|P-value:1.79E-8 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.47|P-value:1.57E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.36|P-value:2.47E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.60|P-value:9.32E-5 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:4.12|P-value:9.26E-6 ID:SGTC_1686|Compound:st019653|FD-Score:3.51|P-value:1.34E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.34|P-value:2.61E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.76|P-value:4.80E-5 ID:SGTC_2205|Compound:7238770|FD-Score:-3.12|P-value:5.76E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.86|P-value:3.10E-5 ID:SGTC_2298|Compound:7976326|FD-Score:-3.00|P-value:8.99E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.13|P-value:5.72E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.10|P-value:6.36E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.78|P-value:4.29E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.02|P-value:8.26E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-4.35|P-value:3.07E-6 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.41|P-value:1.98E-4 ID:SGTC_2821|Compound:7996764|FD-Score:5.71|P-value:1.54E-9 ID:SGTC_2823|Compound:7987624|FD-Score:3.15|P-value:5.39E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.08|P-value:1.11E-5 ID:SGTC_2865|Compound:9030313|FD-Score:3.06|P-value:7.41E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-3.01|P-value:8.80E-4 ID:SGTC_3116|Compound:9124943|FD-Score:-3.22|P-value:4.00E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.52|P-value:1.27E-4 ID:SGTC_3264|Compound:9137442|FD-Score:3.87|P-value:2.93E-5 ID:SGTC_3336|Compound:9143619|FD-Score:3.18|P-value:4.84E-4 ID:SGTC_3344|Compound:9148862|FD-Score:3.49|P-value:1.44E-4 ID:SGTC_3345|Compound:9148410|FD-Score:3.36|P-value:2.40E-4 ID:SGTC_3356|Compound:9151811|FD-Score:-3.34|P-value:2.51E-4

Top fitness defect scores for YLR254C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2821 7996764 5.71 71.4 µM 1.54E-9 8 5.73E-9
2 SGTC_1032 k061-1018 5.31 98.7 µM 1.77E-8 5 5.53E-8
3 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 4.12 61.8 µM 9.26E-6 ergosterol biosynthesis 7 1.86E-5
4 SGTC_1028 k015-0029 4.12 4.8 µM 9.56E-6 19 1.91E-5
5 SGTC_852 0418-0143 4.07 439.0 µM 1.19E-5 calcium & mitochondrial duress 64 2.35E-5
6 SGTC_3264 9137442 3.87 49.5 µM 2.93E-5 15 5.43E-5
7 SGTC_2297 7971671 3.86 152.3 µM 3.10E-5 RNA processing & uracil transport 30 5.72E-5
8 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.78 3.7 µM 4.29E-5 95 7.74E-5
9 SGTC_2147 5545932 3.76 89.7 µM 4.80E-5 ergosterol biosynthesis 17 8.58E-5
10 SGTC_480 am 92016 3.64 50.0 µM 7.88E-5 20 1.36E-4
11 SGTC_1631 benzylvanillin 3.60 81.9 µM 9.32E-5 Golgi 37 1.59E-4
12 SGTC_3146 9095609 3.52 49.5 µM 1.27E-4 29 2.13E-4
13 SGTC_1686 st019653 3.51 115.5 µM 1.34E-4 mitochondrial processes 19 2.23E-4
14 SGTC_3344 9148862 3.49 3.9 µM 1.44E-4 21 2.39E-4
15 SGTC_1460 k062-0059 3.47 9.2 µM 1.57E-4 Golgi 27 2.59E-4
16 SGTC_2721 ifenprodil 3.41 61.4 µM 1.98E-4 plasma membrane duress 41 3.22E-4
17 SGTC_3345 9148410 3.36 3.6 µM 2.40E-4 17 3.84E-4
18 SGTC_421 streptovitacin 3.36 30.0 mM 2.41E-4 47 3.86E-4
19 SGTC_1587 estradiol valerate 3.36 56.1 µM 2.47E-4 28 3.94E-4
20 SGTC_1726 st035556 3.34 14.6 µM 2.61E-4 64 4.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.213 7.97E-36 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.206 1.95E-33 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.182 1.76E-26 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.160 9.44E-21 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.148 6.02E-18 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.146 2.21E-17 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.145 2.93E-17 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.136 2.35E-15 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.134 7.25E-15 YJR092W BUD4 hom Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p
0.128 8.60E-14 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.125 3.50E-13 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.124 5.36E-13 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.123 1.01E-12 YLR306W UBC12 hom Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes
0.122 1.10E-12 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.120 3.69E-12 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress