YLR269C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR269C / YLR269C

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:-3.91|P-value:4.72E-5 ID:SGTC_32|Compound:0928-0142|FD-Score:3.17|P-value:6.24E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:3.99|P-value:2.60E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:3.08|P-value:8.68E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-3.80|P-value:7.46E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:-4.82|P-value:7.10E-7 ID:SGTC_61|Compound:0978-8327|FD-Score:-4.43|P-value:4.79E-6 ID:SGTC_278|Compound:4092-0821|FD-Score:4.70|P-value:9.38E-7 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.64|P-value:1.08E-4 ID:SGTC_508|Compound:roscovitine|FD-Score:3.25|P-value:4.70E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.45|P-value:2.89E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.19|P-value:5.85E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.46|P-value:2.82E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.16|P-value:6.52E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.73|P-value:9.97E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.50|P-value:1.88E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:6.95|P-value:1.00E-12 ID:SGTC_1756|Compound:st041558|FD-Score:4.47|P-value:2.85E-6 ID:SGTC_1803|Compound:st050068|FD-Score:-3.30|P-value:4.97E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.78|P-value:7.91E-5 ID:SGTC_2084|Compound:5306078|FD-Score:-3.68|P-value:1.21E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.87|P-value:4.17E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.11|P-value:7.78E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-4.09|P-value:2.18E-5 ID:SGTC_2412|Compound:st077135|FD-Score:-3.23|P-value:6.37E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:5.53|P-value:1.07E-8 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.35|P-value:4.12E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.10|P-value:8.00E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.17|P-value:7.97E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.41|P-value:3.40E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.77|P-value:6.47E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.17|P-value:6.23E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-3.31|P-value:4.75E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.43|P-value:3.09E-4 ID:SGTC_3069|Compound:9117009|FD-Score:-4.37|P-value:6.41E-6 ID:SGTC_3071|Compound:9117417|FD-Score:-4.04|P-value:2.69E-5 ID:SGTC_3134|Compound:9127454|FD-Score:3.06|P-value:9.36E-4 ID:SGTC_3222|Compound:9128301|FD-Score:4.24|P-value:8.62E-6 ID:SGTC_21|Compound:0849-0113|FD-Score:-3.91|P-value:4.72E-5 ID:SGTC_32|Compound:0928-0142|FD-Score:3.17|P-value:6.24E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:3.99|P-value:2.60E-5 ID:SGTC_53|Compound:0973-0023|FD-Score:3.08|P-value:8.68E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-3.80|P-value:7.46E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:-4.82|P-value:7.10E-7 ID:SGTC_61|Compound:0978-8327|FD-Score:-4.43|P-value:4.79E-6 ID:SGTC_278|Compound:4092-0821|FD-Score:4.70|P-value:9.38E-7 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.64|P-value:1.08E-4 ID:SGTC_508|Compound:roscovitine|FD-Score:3.25|P-value:4.70E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.45|P-value:2.89E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.19|P-value:5.85E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.46|P-value:2.82E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.16|P-value:6.52E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.73|P-value:9.97E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.50|P-value:1.88E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:6.95|P-value:1.00E-12 ID:SGTC_1756|Compound:st041558|FD-Score:4.47|P-value:2.85E-6 ID:SGTC_1803|Compound:st050068|FD-Score:-3.30|P-value:4.97E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.78|P-value:7.91E-5 ID:SGTC_2084|Compound:5306078|FD-Score:-3.68|P-value:1.21E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.87|P-value:4.17E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.11|P-value:7.78E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-4.09|P-value:2.18E-5 ID:SGTC_2412|Compound:st077135|FD-Score:-3.23|P-value:6.37E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:5.53|P-value:1.07E-8 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.35|P-value:4.12E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.10|P-value:8.00E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.17|P-value:7.97E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.41|P-value:3.40E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.77|P-value:6.47E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.17|P-value:6.23E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-3.31|P-value:4.75E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-3.43|P-value:3.09E-4 ID:SGTC_3069|Compound:9117009|FD-Score:-4.37|P-value:6.41E-6 ID:SGTC_3071|Compound:9117417|FD-Score:-4.04|P-value:2.69E-5 ID:SGTC_3134|Compound:9127454|FD-Score:3.06|P-value:9.36E-4 ID:SGTC_3222|Compound:9128301|FD-Score:4.24|P-value:8.62E-6

Top fitness defect scores for YLR269C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1306 1185-0270 6.95 9.0 µM 1.00E-12 Golgi 26 1.80E-12
2 SGTC_2419 paclitaxel 5.53 166.5 µM 1.07E-8 8 1.62E-8
3 SGTC_278 4092-0821 4.70 23.9 µM 9.38E-7 plasma membrane duress 27 1.30E-6
4 SGTC_1756 st041558 4.47 35.5 µM 2.85E-6 6 3.86E-6
5 SGTC_3222 9128301 4.24 49.5 µM 8.62E-6 60S ribosome export 21 1.14E-5
6 SGTC_52 0329-0193 3.99 875.0 nM 2.60E-5 TSC3-RPN4 30 3.37E-5
7 SGTC_2098 5376439 3.87 882.5 nM 4.17E-5 14 5.35E-5
8 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 3.77 15.3 µM 6.47E-5 38 8.23E-5
9 SGTC_423 5-fluorouracil 3.64 457.0 µM 1.08E-4 exosome 31 1.35E-4
10 SGTC_1250 0485-0349 3.50 40.2 µM 1.88E-4 51 2.34E-4
11 SGTC_508 roscovitine 3.25 141.0 µM 4.70E-4 16 5.73E-4
12 SGTC_943 3253-1379 3.19 105.0 µM 5.85E-4 49 7.10E-4
13 SGTC_2688 kanamycin b 3.17 96.7 µM 6.23E-4 calcium & mitochondrial duress 499 7.56E-4
14 SGTC_32 0928-0142 3.17 34.1 µM 6.24E-4 TSC3-RPN4 24 7.56E-4
15 SGTC_1156 4092-0367 3.16 4.9 µM 6.52E-4 61 7.89E-4
16 SGTC_2409 alverine citrate 3.11 64.0 µM 7.78E-4 97 9.38E-4
17 SGTC_2495 cafestol 3.10 54.5 µM 8.00E-4 Golgi 63 9.64E-4
18 SGTC_53 0973-0023 3.08 40.0 µM 8.68E-4 RNA processing & uracil transport 43 0.00104
19 SGTC_3134 9127454 3.06 49.5 µM 9.36E-4 35 0.00112
20 SGTC_1775 st081588 2.92 35.2 µM 0.00148 60S ribosome export 77 0.00176

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.07E-12 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.114 3.88E-11 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.112 7.24E-11 YPR175W DPB2 het Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for maintenance of fidelity of chromosomal replication; expression peaks at the G1/S phase boundary; Cdc28p substrate
0.112 8.69E-11 YBR065C ECM2 hom Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p
0.106 7.72E-10 YLR306W UBC12 hom Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes
0.106 7.90E-10 YOR216C RUD3 hom Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1
0.104 1.37E-9 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.102 3.20E-9 YPR176C BET2 het Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.101 4.25E-9 YGR039W_d YGR039W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
0.099 9.26E-9 YDL085W NDE2 hom Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
0.097 1.74E-8 YJL032W_d YJL032W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase
0.094 4.41E-8 YKL184W SPE1 hom Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation
0.094 4.88E-8 YLR309C IMH1 hom Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi
0.093 7.34E-8 YLR190W MMR1 hom Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
0.092 9.58E-8 YGR049W SCM4 hom Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation