YLR273C / PIG1

Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR273C / PIG1

Click on Significant Values for Screen Details ID:SGTC_270|Compound:tamoxifen|FD-Score:4.19|P-value:7.45E-7 ID:SGTC_448|Compound:monastrol|FD-Score:3.21|P-value:1.12E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:-3.00|P-value:3.37E-4 ID:SGTC_510|Compound:ag-490|FD-Score:3.34|P-value:6.30E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:4.65|P-value:4.80E-8 ID:SGTC_705|Compound:1124-0212|FD-Score:4.24|P-value:5.75E-7 ID:SGTC_777|Compound:1315-0167|FD-Score:2.90|P-value:4.23E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-2.74|P-value:9.55E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:2.73|P-value:8.38E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.96|P-value:2.68E-6 ID:SGTC_976|Compound:1348-1067|FD-Score:2.85|P-value:5.23E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.89|P-value:3.93E-6 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.59|P-value:1.84E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.56|P-value:2.70E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:-2.94|P-value:4.33E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.83|P-value:1.54E-8 ID:SGTC_1178|Compound:0988-0033|FD-Score:2.85|P-value:5.16E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:-2.92|P-value:4.62E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.35|P-value:5.84E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:-2.95|P-value:4.11E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.76|P-value:7.80E-6 ID:SGTC_1344|Compound:1488-0097|FD-Score:2.96|P-value:3.35E-4 ID:SGTC_1656|Compound:st012921|FD-Score:2.75|P-value:7.62E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.26|P-value:8.85E-5 ID:SGTC_1672|Compound:st016598|FD-Score:3.73|P-value:9.34E-6 ID:SGTC_1682|Compound:st012968|FD-Score:-2.95|P-value:4.10E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.59|P-value:1.87E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.47|P-value:3.35E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:2.86|P-value:5.06E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.24|P-value:9.95E-5 ID:SGTC_1896|Compound:st058441|FD-Score:3.73|P-value:9.36E-6 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-4.00|P-value:2.81E-6 ID:SGTC_1970|Compound:st070122|FD-Score:2.87|P-value:4.81E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-2.85|P-value:6.19E-4 ID:SGTC_2186|Compound:6124449|FD-Score:-2.80|P-value:7.42E-4 ID:SGTC_2242|Compound:6630449|FD-Score:2.73|P-value:8.50E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-2.92|P-value:4.56E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:-2.87|P-value:5.78E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:2.80|P-value:6.43E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.36|P-value:5.73E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:2.76|P-value:7.31E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-3.07|P-value:2.43E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.27|P-value:1.04E-4 ID:SGTC_2995|Compound:9067767|FD-Score:-2.88|P-value:5.47E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-4.21|P-value:8.56E-7 ID:SGTC_3137|Compound:9097352|FD-Score:3.52|P-value:2.59E-5 ID:SGTC_3146|Compound:9095609|FD-Score:2.94|P-value:3.59E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-2.75|P-value:9.00E-4 ID:SGTC_3206|Compound:9114350|FD-Score:3.51|P-value:2.74E-5 ID:SGTC_3293|Compound:9120939|FD-Score:2.90|P-value:4.32E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.90|P-value:3.71E-6 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.19|P-value:7.45E-7 ID:SGTC_448|Compound:monastrol|FD-Score:3.21|P-value:1.12E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:-3.00|P-value:3.37E-4 ID:SGTC_510|Compound:ag-490|FD-Score:3.34|P-value:6.30E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:4.65|P-value:4.80E-8 ID:SGTC_705|Compound:1124-0212|FD-Score:4.24|P-value:5.75E-7 ID:SGTC_777|Compound:1315-0167|FD-Score:2.90|P-value:4.23E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-2.74|P-value:9.55E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:2.73|P-value:8.38E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.96|P-value:2.68E-6 ID:SGTC_976|Compound:1348-1067|FD-Score:2.85|P-value:5.23E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.89|P-value:3.93E-6 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.59|P-value:1.84E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.56|P-value:2.70E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:-2.94|P-value:4.33E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.83|P-value:1.54E-8 ID:SGTC_1178|Compound:0988-0033|FD-Score:2.85|P-value:5.16E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:-2.92|P-value:4.62E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.35|P-value:5.84E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:-2.95|P-value:4.11E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.76|P-value:7.80E-6 ID:SGTC_1344|Compound:1488-0097|FD-Score:2.96|P-value:3.35E-4 ID:SGTC_1656|Compound:st012921|FD-Score:2.75|P-value:7.62E-4 ID:SGTC_1664|Compound:st014217|FD-Score:3.26|P-value:8.85E-5 ID:SGTC_1672|Compound:st016598|FD-Score:3.73|P-value:9.34E-6 ID:SGTC_1682|Compound:st012968|FD-Score:-2.95|P-value:4.10E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.59|P-value:1.87E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.47|P-value:3.35E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:2.86|P-value:5.06E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.24|P-value:9.95E-5 ID:SGTC_1896|Compound:st058441|FD-Score:3.73|P-value:9.36E-6 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-4.00|P-value:2.81E-6 ID:SGTC_1970|Compound:st070122|FD-Score:2.87|P-value:4.81E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-2.85|P-value:6.19E-4 ID:SGTC_2186|Compound:6124449|FD-Score:-2.80|P-value:7.42E-4 ID:SGTC_2242|Compound:6630449|FD-Score:2.73|P-value:8.50E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-2.92|P-value:4.56E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:-2.87|P-value:5.78E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:2.80|P-value:6.43E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.36|P-value:5.73E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:2.76|P-value:7.31E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-3.07|P-value:2.43E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.27|P-value:1.04E-4 ID:SGTC_2995|Compound:9067767|FD-Score:-2.88|P-value:5.47E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-4.21|P-value:8.56E-7 ID:SGTC_3137|Compound:9097352|FD-Score:3.52|P-value:2.59E-5 ID:SGTC_3146|Compound:9095609|FD-Score:2.94|P-value:3.59E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-2.75|P-value:9.00E-4 ID:SGTC_3206|Compound:9114350|FD-Score:3.51|P-value:2.74E-5 ID:SGTC_3293|Compound:9120939|FD-Score:2.90|P-value:4.32E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.90|P-value:3.71E-6

Top fitness defect scores for YLR273C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1132 3456-3614 4.83 2.5 µM 1.54E-8 tubulin folding & SWR complex 19 6.96E-7
2 SGTC_685 1278-0033 4.65 54.9 µM 4.80E-8 60S ribosome export 10 1.67E-6
3 SGTC_705 1124-0212 4.24 310.0 µM 5.75E-7 9 1.13E-5
4 SGTC_270 tamoxifen 4.19 5.5 µM 7.45E-7 NEO1 21 1.38E-5
5 SGTC_974 1326-0144 3.96 138.0 µM 2.68E-6 ERG2 42 3.71E-5
6 SGTC_3347 9188721 3.90 44.7 µM 3.71E-6 25 4.77E-5
7 SGTC_1008 4106-0037 3.89 6.0 µM 3.93E-6 PDR1 22 4.99E-5
8 SGTC_1279 0874-0590 3.76 65.2 µM 7.80E-6 38 8.46E-5
9 SGTC_1672 st016598 3.73 6.5 µM 9.34E-6 endomembrane recycling 76 9.72E-5
10 SGTC_1896 st058441 3.73 89.0 µM 9.36E-6 18 9.74E-5
11 SGTC_1010 4112-3296 3.59 15.2 µM 1.84E-5 27 1.64E-4
12 SGTC_1729 st035615 3.59 46.0 µM 1.87E-5 48 1.67E-4
13 SGTC_3137 9097352 3.52 49.5 µM 2.59E-5 57 2.14E-4
14 SGTC_3206 9114350 3.51 49.5 µM 2.74E-5 32 2.24E-4
15 SGTC_1730 st033808 3.47 45.1 µM 3.35E-5 58 2.61E-4
16 SGTC_2580 diallyl disulphide 3.36 81.4 µM 5.73E-5 36 3.95E-4
17 SGTC_1218 1348-1416 3.35 30.7 µM 5.84E-5 SWF1 & branched chain AA biosynthesis 36 4.01E-4
18 SGTC_510 ag-490 3.34 170.0 µM 6.30E-5 10 4.25E-4
19 SGTC_1664 st014217 3.26 9.0 µM 8.85E-5 60S ribosome export 29 5.54E-4
20 SGTC_1892 st058411 3.24 7.4 µM 9.95E-5 57 6.06E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.34E-12 YHR040W BCD1 het Essential protein required for the accumulation of box C/D snoRNA
0.104 1.82E-9 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.101 5.13E-9 YMR184W ADD37 hom Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress
0.084 1.07E-6 YDR352W YPQ2 hom Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter
0.082 1.86E-6 YDR168W CDC37 het Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding
0.081 2.88E-6 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.079 5.30E-6 YOR181W LAS17 het Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
0.078 5.90E-6 YAL051W OAF1 hom Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication
0.078 6.75E-6 YDR409W SIZ1 hom SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring
0.077 8.07E-6 YFR021W ATG18 hom Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood
0.077 8.32E-6 YOL079W_d YOL079W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.076 1.08E-5 YOR285W RDL1 hom Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress
0.075 1.42E-5 YGL199C_d YGL199C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W
0.073 2.05E-5 YJL093C TOK1 hom Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
0.072 3.10E-5 YKL183W LOT5 hom Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress