HIPHOP chemogenomics database
YLR281C_p 
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YLR281C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.125 | 4.38E-13 | YEL040W | UTR2 | hom | Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck |
| 0.118 | 7.47E-12 | YDR263C | DIN7 | hom | Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination |
| 0.114 | 3.40E-11 | YPR013C_p | CMR3_p | hom | Putative zinc finger protein; YPR013C is not an essential gene |
| 0.104 | 2.07E-9 | YBL065W_d | YBL065W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene |
| 0.103 | 2.06E-9 | YGL009C | LEU1 | hom | Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway |
| 0.096 | 2.38E-8 | YDR153C | ENT5 | hom | Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin |
| 0.094 | 4.51E-8 | YLR152C_p | YLR152C_p | hom | Putative protein of unknown function; YLR152C is not an essential gene |
| 0.094 | 4.88E-8 | YLR049C_p | YLR049C_p | hom | Putative protein of unknown function |
| 0.094 | 5.05E-8 | YGL245W | GUS1 | het | Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress |
| 0.090 | 1.68E-7 | YER118C | SHO1 | hom | Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p |
| 0.088 | 2.96E-7 | YGR170W | PSD2 | hom | Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine |
| 0.088 | 3.77E-7 | YMR271C | URA10 | hom | Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication |
| 0.082 | 1.95E-6 | YBR150C | TBS1 | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication |
| 0.081 | 2.49E-6 | YOR161C | PNS1 | hom | Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport |
| 0.080 | 3.98E-6 | YGL257C | MNT2 | hom | Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans |