YLR294C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR294C / YLR294C

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.06|P-value:2.61E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.50|P-value:2.19E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.36|P-value:4.16E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.33|P-value:4.05E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.91|P-value:2.80E-12 ID:SGTC_386|Compound:1509-0011|FD-Score:3.31|P-value:5.01E-4 ID:SGTC_389|Compound:tpck|FD-Score:-3.69|P-value:1.06E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.14|P-value:8.92E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.61|P-value:2.19E-6 ID:SGTC_717|Compound:1532-0246|FD-Score:3.18|P-value:7.94E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:5.43|P-value:3.05E-8 ID:SGTC_745|Compound:0469-0705|FD-Score:5.50|P-value:2.13E-8 ID:SGTC_769|Compound:0302-0231|FD-Score:3.27|P-value:5.79E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.38|P-value:3.83E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-4.00|P-value:2.93E-5 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.56|P-value:1.98E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.27|P-value:5.17E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.13|P-value:9.34E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.91|P-value:4.96E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.39|P-value:3.74E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.22|P-value:6.73E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.18|P-value:7.69E-4 ID:SGTC_1889|Compound:st059080|FD-Score:4.52|P-value:3.39E-6 ID:SGTC_1953|Compound:st076800|FD-Score:3.31|P-value:4.89E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.38|P-value:6.29E-6 ID:SGTC_2292|Compound:7671323|FD-Score:5.06|P-value:2.31E-7 ID:SGTC_2333|Compound:9017922|FD-Score:3.56|P-value:1.97E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.15|P-value:8.54E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.34|P-value:4.43E-4 ID:SGTC_2623|Compound:humulene|FD-Score:3.76|P-value:9.05E-5 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.22|P-value:6.85E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.84|P-value:6.64E-5 ID:SGTC_2783|Compound:7738165|FD-Score:-3.13|P-value:8.21E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-3.48|P-value:2.41E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.36|P-value:4.11E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-4.86|P-value:5.51E-7 ID:SGTC_2942|Compound:9052777|FD-Score:3.65|P-value:1.39E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.53|P-value:2.23E-4 ID:SGTC_3035|Compound:9091303|FD-Score:3.24|P-value:6.23E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-5.26|P-value:6.49E-8 ID:SGTC_3100|Compound:9120536|FD-Score:-3.17|P-value:7.27E-4 ID:SGTC_3112|Compound:9123419|FD-Score:3.23|P-value:6.57E-4 ID:SGTC_3149|Compound:9097855|FD-Score:4.42|P-value:5.42E-6 ID:SGTC_3186|Compound:9110464|FD-Score:3.78|P-value:8.36E-5 ID:SGTC_3212|Compound:9128307|FD-Score:3.13|P-value:9.33E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-4.31|P-value:7.76E-6 ID:SGTC_3356|Compound:9151811|FD-Score:-5.38|P-value:3.41E-8 ID:SGTC_8|Compound:0354-0001|FD-Score:4.06|P-value:2.61E-5 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.50|P-value:2.19E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.36|P-value:4.16E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.33|P-value:4.05E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:6.91|P-value:2.80E-12 ID:SGTC_386|Compound:1509-0011|FD-Score:3.31|P-value:5.01E-4 ID:SGTC_389|Compound:tpck|FD-Score:-3.69|P-value:1.06E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.14|P-value:8.92E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.61|P-value:2.19E-6 ID:SGTC_717|Compound:1532-0246|FD-Score:3.18|P-value:7.94E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:5.43|P-value:3.05E-8 ID:SGTC_745|Compound:0469-0705|FD-Score:5.50|P-value:2.13E-8 ID:SGTC_769|Compound:0302-0231|FD-Score:3.27|P-value:5.79E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.38|P-value:3.83E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-4.00|P-value:2.93E-5 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.56|P-value:1.98E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.27|P-value:5.17E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.13|P-value:9.34E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.91|P-value:4.96E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.39|P-value:3.74E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.22|P-value:6.73E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.18|P-value:7.69E-4 ID:SGTC_1889|Compound:st059080|FD-Score:4.52|P-value:3.39E-6 ID:SGTC_1953|Compound:st076800|FD-Score:3.31|P-value:4.89E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.38|P-value:6.29E-6 ID:SGTC_2292|Compound:7671323|FD-Score:5.06|P-value:2.31E-7 ID:SGTC_2333|Compound:9017922|FD-Score:3.56|P-value:1.97E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.15|P-value:8.54E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.34|P-value:4.43E-4 ID:SGTC_2623|Compound:humulene|FD-Score:3.76|P-value:9.05E-5 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.22|P-value:6.85E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.84|P-value:6.64E-5 ID:SGTC_2783|Compound:7738165|FD-Score:-3.13|P-value:8.21E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-3.48|P-value:2.41E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.36|P-value:4.11E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-4.86|P-value:5.51E-7 ID:SGTC_2942|Compound:9052777|FD-Score:3.65|P-value:1.39E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.53|P-value:2.23E-4 ID:SGTC_3035|Compound:9091303|FD-Score:3.24|P-value:6.23E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-5.26|P-value:6.49E-8 ID:SGTC_3100|Compound:9120536|FD-Score:-3.17|P-value:7.27E-4 ID:SGTC_3112|Compound:9123419|FD-Score:3.23|P-value:6.57E-4 ID:SGTC_3149|Compound:9097855|FD-Score:4.42|P-value:5.42E-6 ID:SGTC_3186|Compound:9110464|FD-Score:3.78|P-value:8.36E-5 ID:SGTC_3212|Compound:9128307|FD-Score:3.13|P-value:9.33E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-4.31|P-value:7.76E-6 ID:SGTC_3356|Compound:9151811|FD-Score:-5.38|P-value:3.41E-8

Top fitness defect scores for YLR294C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 6.91 5.3 µM 2.80E-12 270 2.47E-12
2 SGTC_745 0469-0705 5.50 296.0 µM 2.13E-8 mitochondrial processes 5 1.93E-8
3 SGTC_729 4092-0585 5.43 94.1 µM 3.05E-8 5 2.76E-8
4 SGTC_2292 7671323 5.06 168.1 µM 2.31E-7 RNA processing & uracil transport 16 2.10E-7
5 SGTC_682 0kpi-0099 4.61 17.0 µM 2.19E-6 50 2.01E-6
6 SGTC_1889 st059080 4.52 5.2 µM 3.39E-6 11 3.13E-6
7 SGTC_3149 9097855 4.42 49.5 µM 5.42E-6 Golgi 16 5.00E-6
8 SGTC_2251 lansoprazole 4.38 556.0 µM 6.29E-6 13 5.81E-6
9 SGTC_8 0354-0001 4.06 70.0 µM 2.61E-5 74 2.42E-5
10 SGTC_1281 0884-0031 3.91 11.8 µM 4.96E-5 fatty acid desaturase (OLE1) 23 4.62E-5
11 SGTC_2782 7736369 3.84 71.4 µM 6.64E-5 46 6.19E-5
12 SGTC_3186 9110464 3.78 49.5 µM 8.36E-5 RPP1 & pyrimidine depletion 17 7.81E-5
13 SGTC_2623 humulene 3.76 100.0 µM 9.05E-5 24 8.46E-5
14 SGTC_2942 9052777 3.65 62.2 µM 1.39E-4 45 1.30E-4
15 SGTC_2333 9017922 3.56 200.0 µM 1.97E-4 39 1.85E-4
16 SGTC_1080 nisoldipine 3.56 24.4 µM 1.98E-4 TSC3-RPN4 41 1.85E-4
17 SGTC_2943 9068529 3.53 45.3 µM 2.23E-4 32 2.09E-4
18 SGTC_1423 4048-0112 3.39 5.6 µM 3.74E-4 45 3.52E-4
19 SGTC_1070 indatraline 3.38 8.8 µM 3.83E-4 60S ribosome export 45 3.60E-4
20 SGTC_2849 9019321 3.36 13.0 µM 4.11E-4 49 3.87E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.227 2.56E-40 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.220 3.88E-38 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.212 1.91E-35 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.210 9.21E-35 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.206 2.18E-33 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.205 4.97E-33 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.200 1.55E-31 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.196 1.89E-30 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.189 1.99E-28 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.189 2.53E-28 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.188 5.04E-28 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.188 6.50E-28 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.187 8.77E-28 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.185 3.26E-27 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.183 1.03E-26 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p