YLR297W

Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR297W / YLR297W

Click on Significant Values for Screen Details

Top fitness defect scores for YLR297W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1244 0416-0015 5.91 52.5 µM 2.17E-10 ERG2 5 1.74E-9
2 SGTC_812 4251-0442 5.30 148.0 µM 1.06E-8 4 5.64E-8
3 SGTC_1378 2093-0007 5.21 380.0 nM 1.84E-8 5 9.26E-8
4 SGTC_2818 7996756 5.07 13.0 µM 4.31E-8 7 1.98E-7
5 SGTC_2925 9010536 5.02 32.5 µM 5.75E-8 azole & statin 24 2.57E-7
6 SGTC_1725 st036284 4.75 20.6 µM 2.69E-7 16 1.02E-6
7 SGTC_761 k216-0224 4.40 480.0 µM 1.68E-6 10 5.29E-6
8 SGTC_2592 piperlongumine 3.85 83.3 µM 2.47E-5 TSC3-RPN4 45 5.93E-5
9 SGTC_1146 3579-1023 3.74 7.0 µM 3.96E-5 21 9.06E-5
10 SGTC_638 3970-0837 3.67 4.1 µM 5.54E-5 50 1.23E-4
11 SGTC_2281 7943571 3.44 200.0 µM 1.46E-4 21 2.94E-4
12 SGTC_1742 st038235 3.37 28.9 µM 1.90E-4 mitochondrial stress 147 3.72E-4
13 SGTC_2713 st079149 3.31 53.4 µM 2.46E-4 44 4.69E-4
14 SGTC_950 1165-0508 3.31 94.1 µM 2.48E-4 48 4.72E-4
15 SGTC_1125 tnp00248 3.22 1.3 µM 3.50E-4 75 6.45E-4
16 SGTC_2830 7992007 3.13 71.4 µM 4.98E-4 47 8.86E-4
17 SGTC_231 b-estradiol 3.07 524.0 µM 6.13E-4 28 0.00107
18 SGTC_1728 st035614 3.06 33.8 µM 6.37E-4 107 0.00111
19 SGTC_758 0868-0029 3.05 16.0 µM 6.55E-4 30 0.00113
20 SGTC_2227 7312221 3.02 64.1 µM 7.52E-4 12 0.00128

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.46E-10 YJR108W ABM1 hom Protein of unknown function, required for normal microtubule organization
0.109 2.21E-10 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.108 3.14E-10 YJL044C GYP6 hom GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport
0.106 9.13E-10 YOR289W_p YOR289W_p hom Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.102 2.76E-9 YKL022C CDC16 het Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation
0.101 3.98E-9 YPL164C MLH3 hom Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability
0.097 1.63E-8 YOR252W TMA16 hom Protein of unknown function that associates with ribosomes
0.095 2.98E-8 YGL063W PUS2 hom Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification
0.095 3.67E-8 YGR019W UGA1 hom Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress
0.091 1.23E-7 YLR263W RED1 hom Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p
0.090 1.83E-7 YOR223W YOR223W hom Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3
0.090 1.91E-7 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.087 4.20E-7 YOR334W MRS2 hom Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns
0.086 6.36E-7 YKL187C FAT3 hom Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
0.086 7.09E-7 YFR017C IGD1 hom Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication