HIPHOP chemogenomics database
YLR321C / SFH1 
Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YLR321C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.520 | 7.47E-232 | YLR033W | RSC58 | het | Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance |
| 0.482 | 3.18E-195 | YFR037C | RSC8 | het | Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters |
| 0.474 | 7.73E-188 | YML127W | RSC9 | het | Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway |
| 0.463 | 3.00E-178 | YIL126W | STH1 | het | ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p |
| 0.439 | 9.20E-158 | YER165W | PAB1 | het | Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G |
| 0.420 | 1.51E-143 | YPR034W | ARP7 | het | Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation |
| 0.404 | 1.22E-131 | YPR104C | FHL1 | het | Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants |
| 0.389 | 2.58E-121 | YNR016C | ACC1 | het | Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; |
| 0.388 | 4.71E-121 | YBR091C | TIM12 | het | Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins |
| 0.383 | 5.31E-117 | YJL081C | ARP4 | het | Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes |
| 0.365 | 2.05E-106 | YMR033W | ARP9 | het | Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation |
| 0.352 | 6.84E-98 | YJL039C | NUP192 | het | Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205 |
| 0.340 | 9.86E-92 | YOR236W | DFR1 | het | Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism |
| 0.339 | 4.43E-91 | YDR172W | SUP35 | het | Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype |
| 0.318 | 1.41E-79 | YGL093W | SPC105 | het | Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components |