YLR334C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR334C / YLR334C

Click on Significant Values for Screen Details ID:SGTC_326|Compound:k292-0812|FD-Score:-3.04|P-value:5.57E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.14|P-value:3.03E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:2.86|P-value:8.61E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.17|P-value:2.64E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:4.63|P-value:2.22E-7 ID:SGTC_592|Compound:k241-0073|FD-Score:6.13|P-value:1.22E-11 ID:SGTC_605|Compound:1315-0399|FD-Score:-3.01|P-value:6.22E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.74|P-value:2.23E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-4.56|P-value:4.65E-7 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.26|P-value:2.34E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:-3.16|P-value:3.40E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.05|P-value:4.17E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.19|P-value:2.41E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.38|P-value:1.39E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.30|P-value:1.56E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.35|P-value:1.28E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:-3.43|P-value:1.15E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.02|P-value:4.85E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.38|P-value:1.38E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.80|P-value:2.24E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-3.03|P-value:5.79E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.35|P-value:1.28E-4 ID:SGTC_2310|Compound:7668677|FD-Score:2.95|P-value:6.14E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.22|P-value:2.15E-4 ID:SGTC_2363|Compound:9053361|FD-Score:4.91|P-value:4.35E-8 ID:SGTC_2368|Compound:9071271|FD-Score:-3.58|P-value:5.95E-5 ID:SGTC_2398|Compound:5228213|FD-Score:-3.00|P-value:6.40E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:2.92|P-value:7.03E-4 ID:SGTC_2455|Compound:5377712|FD-Score:-3.21|P-value:2.90E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.09|P-value:1.42E-8 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.02|P-value:5.86E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.40|P-value:1.32E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-4.58|P-value:4.14E-7 ID:SGTC_2549|Compound:cedrol|FD-Score:5.06|P-value:1.73E-8 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.04|P-value:5.17E-6 ID:SGTC_2556|Compound:citropten|FD-Score:3.60|P-value:4.29E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:3.32|P-value:1.40E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-2.90|P-value:9.20E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.45|P-value:8.19E-5 ID:SGTC_2706|Compound:st078239|FD-Score:3.03|P-value:4.59E-4 ID:SGTC_2840|Compound:9008771|FD-Score:-4.32|P-value:1.62E-6 ID:SGTC_2918|Compound:7977171|FD-Score:-3.93|P-value:1.17E-5 ID:SGTC_2921|Compound:7974240|FD-Score:-3.03|P-value:5.66E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-3.52|P-value:7.60E-5 ID:SGTC_2992|Compound:9074591|FD-Score:3.29|P-value:1.61E-4 ID:SGTC_3036|Compound:9090181|FD-Score:3.01|P-value:4.88E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.17|P-value:2.61E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-3.43|P-value:1.14E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.39|P-value:1.04E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.81|P-value:1.59E-5 ID:SGTC_3278|Compound:9139605|FD-Score:-3.24|P-value:2.47E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:-3.04|P-value:5.57E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.14|P-value:3.03E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:2.86|P-value:8.61E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.17|P-value:2.64E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:4.63|P-value:2.22E-7 ID:SGTC_592|Compound:k241-0073|FD-Score:6.13|P-value:1.22E-11 ID:SGTC_605|Compound:1315-0399|FD-Score:-3.01|P-value:6.22E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.74|P-value:2.23E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-4.56|P-value:4.65E-7 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.26|P-value:2.34E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:-3.16|P-value:3.40E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.05|P-value:4.17E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.19|P-value:2.41E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-3.38|P-value:1.39E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.30|P-value:1.56E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.35|P-value:1.28E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:-3.43|P-value:1.15E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.02|P-value:4.85E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.38|P-value:1.38E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.80|P-value:2.24E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-3.03|P-value:5.79E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.35|P-value:1.28E-4 ID:SGTC_2310|Compound:7668677|FD-Score:2.95|P-value:6.14E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.22|P-value:2.15E-4 ID:SGTC_2363|Compound:9053361|FD-Score:4.91|P-value:4.35E-8 ID:SGTC_2368|Compound:9071271|FD-Score:-3.58|P-value:5.95E-5 ID:SGTC_2398|Compound:5228213|FD-Score:-3.00|P-value:6.40E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:2.92|P-value:7.03E-4 ID:SGTC_2455|Compound:5377712|FD-Score:-3.21|P-value:2.90E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.09|P-value:1.42E-8 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-3.02|P-value:5.86E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-3.40|P-value:1.32E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-4.58|P-value:4.14E-7 ID:SGTC_2549|Compound:cedrol|FD-Score:5.06|P-value:1.73E-8 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.04|P-value:5.17E-6 ID:SGTC_2556|Compound:citropten|FD-Score:3.60|P-value:4.29E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:3.32|P-value:1.40E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-2.90|P-value:9.20E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.45|P-value:8.19E-5 ID:SGTC_2706|Compound:st078239|FD-Score:3.03|P-value:4.59E-4 ID:SGTC_2840|Compound:9008771|FD-Score:-4.32|P-value:1.62E-6 ID:SGTC_2918|Compound:7977171|FD-Score:-3.93|P-value:1.17E-5 ID:SGTC_2921|Compound:7974240|FD-Score:-3.03|P-value:5.66E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-3.52|P-value:7.60E-5 ID:SGTC_2992|Compound:9074591|FD-Score:3.29|P-value:1.61E-4 ID:SGTC_3036|Compound:9090181|FD-Score:3.01|P-value:4.88E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.17|P-value:2.61E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-3.43|P-value:1.14E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.39|P-value:1.04E-4 ID:SGTC_3276|Compound:9139060|FD-Score:3.81|P-value:1.59E-5 ID:SGTC_3278|Compound:9139605|FD-Score:-3.24|P-value:2.47E-4

Top fitness defect scores for YLR334C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_592 k241-0073 6.13 46.5 µM 1.22E-11 6 4.30E-10
2 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 5.09 3.7 µM 1.42E-8 30 1.76E-7
3 SGTC_2549 cedrol 5.06 20.9 µM 1.73E-8 5 2.08E-7
4 SGTC_2363 9053361 4.91 176.0 µM 4.35E-8 Golgi 16 4.55E-7
5 SGTC_537 1334-0398 4.63 209.0 µM 2.22E-7 11 1.82E-6
6 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 4.04 66.7 µM 5.17E-6 19 2.67E-5
7 SGTC_3276 9139060 3.81 49.5 µM 1.59E-5 60S ribosome export 4 6.95E-5
8 SGTC_608 k048-0125 3.74 159.0 µM 2.23E-5 38 9.25E-5
9 SGTC_2556 citropten 3.60 84.6 µM 4.29E-5 35 1.62E-4
10 SGTC_2636 apigenin dimethyl ether 3.45 100.0 µM 8.19E-5 65 2.81E-4
11 SGTC_3135 9127742 3.39 49.5 µM 1.04E-4 37 3.45E-4
12 SGTC_2259 7964009 3.35 200.0 µM 1.28E-4 superoxide 56 4.10E-4
13 SGTC_1122 capsaicin 3.35 818.6 nM 1.28E-4 47 4.10E-4
14 SGTC_2606 farnesol 3.32 9.8 µM 1.40E-4 43 4.43E-4
15 SGTC_966 1300-0360 3.30 30.2 µM 1.56E-4 heme requiring 49 4.87E-4
16 SGTC_2992 9074591 3.29 71.4 µM 1.61E-4 30 5.00E-4
17 SGTC_2359 9039622 3.22 200.0 µM 2.15E-4 endomembrane recycling 51 6.41E-4
18 SGTC_762 1165-0429 3.19 115.0 µM 2.41E-4 TSC3-RPN4 46 7.05E-4
19 SGTC_3066 9117245 3.17 49.5 µM 2.61E-4 37 7.54E-4
20 SGTC_436 n,n-dimethylsphingosine 3.17 3.3 µM 2.64E-4 55 7.62E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.196 2.02E-30 YPR023C EAF3 hom Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
0.177 4.18E-25 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.173 6.79E-24 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.144 4.58E-17 YML100W TSL1 hom Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication
0.141 2.56E-16 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.133 1.05E-14 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.125 3.17E-13 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.123 8.43E-13 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.121 1.64E-12 YMR034C_p YMR034C_p hom Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
0.120 2.93E-12 YOR010C TIR2 hom Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
0.118 6.39E-12 YPL223C GRE1 hom Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
0.117 1.29E-11 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.113 6.18E-11 YGL149W_d YGL149W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.
0.112 8.25E-11 YLR449W FPR4 hom Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
0.108 2.95E-10 YDL224C WHI4 hom Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication