YLR341W / SPO77

Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR341W / SPO77

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:3.15|P-value:9.58E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.85|P-value:7.28E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.45|P-value:3.21E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:4.39|P-value:7.41E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:4.52|P-value:4.01E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.36|P-value:4.37E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.22|P-value:7.40E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:-4.81|P-value:9.34E-7 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.15|P-value:9.26E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.91|P-value:5.49E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.22|P-value:7.55E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.60|P-value:1.91E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:4.72|P-value:1.55E-6 ID:SGTC_1521|Compound:st012942|FD-Score:-3.28|P-value:5.87E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.22|P-value:7.48E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.71|P-value:1.25E-4 ID:SGTC_1672|Compound:st016598|FD-Score:4.58|P-value:3.01E-6 ID:SGTC_1853|Compound:st056710|FD-Score:3.42|P-value:3.68E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.58|P-value:2.07E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.54|P-value:2.42E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-3.41|P-value:3.59E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.27|P-value:6.33E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.59|P-value:2.01E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.23|P-value:7.09E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.13|P-value:9.95E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.46|P-value:3.22E-4 ID:SGTC_2869|Compound:9037858|FD-Score:3.67|P-value:1.46E-4 ID:SGTC_2918|Compound:7977171|FD-Score:-3.69|P-value:1.28E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.32|P-value:5.19E-4 ID:SGTC_3084|Compound:9116877|FD-Score:-3.27|P-value:6.06E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.35|P-value:4.80E-4 ID:SGTC_3327|Compound:9140648|FD-Score:-3.80|P-value:8.43E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.15|P-value:9.58E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.85|P-value:7.28E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.45|P-value:3.21E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:4.39|P-value:7.41E-6 ID:SGTC_785|Compound:1270-0111|FD-Score:4.52|P-value:4.01E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.36|P-value:4.37E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.22|P-value:7.40E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:-4.81|P-value:9.34E-7 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.15|P-value:9.26E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.91|P-value:5.49E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.22|P-value:7.55E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.60|P-value:1.91E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:4.72|P-value:1.55E-6 ID:SGTC_1521|Compound:st012942|FD-Score:-3.28|P-value:5.87E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:3.22|P-value:7.48E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.71|P-value:1.25E-4 ID:SGTC_1672|Compound:st016598|FD-Score:4.58|P-value:3.01E-6 ID:SGTC_1853|Compound:st056710|FD-Score:3.42|P-value:3.68E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.58|P-value:2.07E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.54|P-value:2.42E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-3.41|P-value:3.59E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.27|P-value:6.33E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.59|P-value:2.01E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.23|P-value:7.09E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.13|P-value:9.95E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.46|P-value:3.22E-4 ID:SGTC_2869|Compound:9037858|FD-Score:3.67|P-value:1.46E-4 ID:SGTC_2918|Compound:7977171|FD-Score:-3.69|P-value:1.28E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.32|P-value:5.19E-4 ID:SGTC_3084|Compound:9116877|FD-Score:-3.27|P-value:6.06E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.35|P-value:4.80E-4 ID:SGTC_3327|Compound:9140648|FD-Score:-3.80|P-value:8.43E-5

Top fitness defect scores for YLR341W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1335 1486-0900 4.72 202.0 µM 1.55E-6 16 1.16E-6
2 SGTC_1672 st016598 4.58 6.5 µM 3.01E-6 endomembrane recycling 51 2.28E-6
3 SGTC_785 1270-0111 4.52 65.3 µM 4.01E-6 16 3.06E-6
4 SGTC_776 4476-4378 4.39 112.0 µM 7.41E-6 ERG2 15 5.74E-6
5 SGTC_362 0310-0100 3.85 9.0 µM 7.28E-5 RPP1 & pyrimidine depletion 38 5.95E-5
6 SGTC_1632 st005650 3.71 90.0 µM 1.25E-4 38 1.03E-4
7 SGTC_2869 9037858 3.67 32.5 µM 1.46E-4 21 1.21E-4
8 SGTC_1324 1418-0026 3.60 34.4 µM 1.91E-4 18 1.59E-4
9 SGTC_2529 gangaleoidin 3.59 93.6 µM 2.01E-4 27 1.68E-4
10 SGTC_2258 7960471 3.58 200.0 µM 2.07E-4 17 1.73E-4
11 SGTC_2273 7815444 3.54 169.1 µM 2.42E-4 37 2.03E-4
12 SGTC_2789 5281112 3.46 71.4 µM 3.22E-4 64 2.72E-4
13 SGTC_1853 st056710 3.42 91.2 µM 3.68E-4 amide catabolism 47 3.12E-4
14 SGTC_3323 9138564 3.35 53.9 µM 4.80E-4 39 4.10E-4
15 SGTC_2922 7999257 3.32 32.5 µM 5.19E-4 22 4.44E-4
16 SGTC_2416 tofa 3.27 880.0 nM 6.33E-4 sphingolipid biosynthesis & PDR1 81 5.44E-4
17 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 3.23 100.0 µM 7.09E-4 59 6.10E-4
18 SGTC_1013 4112-3890 3.22 241.0 µM 7.40E-4 TSC3-RPN4 68 6.38E-4
19 SGTC_1588 farnesol 3.22 29.9 µM 7.48E-4 34 6.45E-4
20 SGTC_1250 0485-0349 3.22 40.2 µM 7.55E-4 66 6.51E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 2.93E-12 YKR028W SAP190 hom Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication
0.115 2.55E-11 YPR009W SUT2 hom Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p
0.090 1.81E-7 YJL218W_p YJL218W_p hom Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
0.089 2.17E-7 YHR126C_p ANS1_p hom Putative GPI protein; transcription dependent upon Azf1p
0.088 3.80E-7 YNL152W INN1 het Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
0.087 4.99E-7 YLR326W_p YLR326W_p hom Putative protein of unknown function, predicted to be palmitoylated
0.084 1.01E-6 YGR287C IMA1 hom Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; specificity for isomaltose, alpha-methylglucoside, and palatinose; member of the IMA isomaltase family
0.084 1.11E-6 YLR402W_d YLR402W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.084 1.11E-6 YGR175C ERG1 het Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
0.083 1.45E-6 YMR034C_p YMR034C_p hom Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
0.081 2.49E-6 YLR405W DUS4 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
0.078 6.09E-6 YKR050W TRK2 hom Component of the Trk1p-Trk2p potassium transport system; TRK2 has a paralog, TRK1, that arose from the whole genome duplication
0.078 6.16E-6 YJL126W NIT2 hom Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
0.078 6.83E-6 YGR263C SAY1 hom Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.075 1.25E-5 YLR328W NMA1 hom Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication