HIPHOP chemogenomics database
YLR348C / DIC1 
Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YLR348C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.123 | 8.08E-13 | YDL015C | TSC13 | het | Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress |
| 0.103 | 2.68E-9 | YKL140W | TGL1 | hom | Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes |
| 0.100 | 5.85E-9 | YFR018C_p | YFR018C_p | hom | Putative protein of unknown function |
| 0.094 | 4.61E-8 | YJL031C | BET4 | het | Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p |
| 0.094 | 4.54E-8 | YKR013W | PRY2 | hom | Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication |
| 0.094 | 4.81E-8 | YBR236C | ABD1 | het | Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA |
| 0.092 | 8.75E-8 | YGL230C_p | YGL230C_p | hom | Putative protein of unknown function; non-essential gene |
| 0.092 | 9.95E-8 | YJL218W_p | YJL218W_p | hom | Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene |
| 0.091 | 1.47E-7 | YGL248W | PDE1 | hom | Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation |
| 0.085 | 8.78E-7 | YGR028W | MSP1 | hom | Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase |
| 0.082 | 2.17E-6 | YDR365C | ESF1 | het | Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels |
| 0.081 | 2.67E-6 | YDR219C | MFB1 | hom | Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding |
| 0.079 | 4.57E-6 | YJL211C_d | YJL211C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2 |
| 0.078 | 5.42E-6 | YLR414C | PUN1 | hom | Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress |
| 0.078 | 7.04E-6 | YBR094W | PBY1 | hom | Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress |