YLR361C / DCR2

Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR361C / DCR2

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:5.54|P-value:1.26E-9 ID:SGTC_57|Compound:miconazole|FD-Score:4.42|P-value:9.44E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.28|P-value:2.62E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:-6.11|P-value:4.22E-11 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.26|P-value:2.79E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.42|P-value:1.48E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:2.97|P-value:6.47E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.15|P-value:3.32E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:-3.70|P-value:4.44E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:3.13|P-value:3.63E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:2.96|P-value:6.73E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.07|P-value:4.41E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:3.73|P-value:2.81E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:-3.28|P-value:2.62E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.08|P-value:5.66E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:2.93|P-value:7.70E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:2.87|P-value:9.30E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.13|P-value:3.49E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.27|P-value:2.70E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:2.88|P-value:8.96E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.36|P-value:1.42E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:-2.93|P-value:9.80E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:-4.05|P-value:8.65E-6 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-3.28|P-value:2.62E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.85|P-value:1.62E-5 ID:SGTC_1734|Compound:st037168|FD-Score:-3.52|P-value:9.65E-5 ID:SGTC_1736|Compound:st036774|FD-Score:-3.02|P-value:7.11E-4 ID:SGTC_1754|Compound:st042065|FD-Score:2.93|P-value:7.47E-4 ID:SGTC_1860|Compound:st056228|FD-Score:-3.04|P-value:6.47E-4 ID:SGTC_1917|Compound:st066507|FD-Score:4.09|P-value:5.02E-6 ID:SGTC_2425|Compound:5628681|FD-Score:-2.96|P-value:8.88E-4 ID:SGTC_2434|Compound:5670830|FD-Score:2.90|P-value:8.43E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.84|P-value:1.74E-5 ID:SGTC_2781|Compound:5567276|FD-Score:4.27|P-value:2.09E-6 ID:SGTC_2960|Compound:9079389|FD-Score:2.99|P-value:6.10E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-3.11|P-value:4.99E-4 ID:SGTC_3207|Compound:9114163|FD-Score:4.16|P-value:3.67E-6 ID:SGTC_50|Compound:0929-0078|FD-Score:5.54|P-value:1.26E-9 ID:SGTC_57|Compound:miconazole|FD-Score:4.42|P-value:9.44E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.28|P-value:2.62E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:-6.11|P-value:4.22E-11 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.26|P-value:2.79E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.42|P-value:1.48E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:2.97|P-value:6.47E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.15|P-value:3.32E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:-3.70|P-value:4.44E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:3.13|P-value:3.63E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:2.96|P-value:6.73E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.07|P-value:4.41E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:3.73|P-value:2.81E-5 ID:SGTC_936|Compound:3005-4620|FD-Score:-3.28|P-value:2.62E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.08|P-value:5.66E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:2.93|P-value:7.70E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:2.87|P-value:9.30E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.13|P-value:3.49E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.27|P-value:2.70E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:2.88|P-value:8.96E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.36|P-value:1.42E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:-2.93|P-value:9.80E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:-4.05|P-value:8.65E-6 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-3.28|P-value:2.62E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.85|P-value:1.62E-5 ID:SGTC_1734|Compound:st037168|FD-Score:-3.52|P-value:9.65E-5 ID:SGTC_1736|Compound:st036774|FD-Score:-3.02|P-value:7.11E-4 ID:SGTC_1754|Compound:st042065|FD-Score:2.93|P-value:7.47E-4 ID:SGTC_1860|Compound:st056228|FD-Score:-3.04|P-value:6.47E-4 ID:SGTC_1917|Compound:st066507|FD-Score:4.09|P-value:5.02E-6 ID:SGTC_2425|Compound:5628681|FD-Score:-2.96|P-value:8.88E-4 ID:SGTC_2434|Compound:5670830|FD-Score:2.90|P-value:8.43E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.84|P-value:1.74E-5 ID:SGTC_2781|Compound:5567276|FD-Score:4.27|P-value:2.09E-6 ID:SGTC_2960|Compound:9079389|FD-Score:2.99|P-value:6.10E-4 ID:SGTC_3006|Compound:9075424|FD-Score:-3.11|P-value:4.99E-4 ID:SGTC_3207|Compound:9114163|FD-Score:4.16|P-value:3.67E-6

Top fitness defect scores for YLR361C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_50 0929-0078 5.54 56.4 µM 1.26E-9 27 1.53E-8
2 SGTC_57 miconazole 4.42 162.5 nM 9.44E-7 ergosterol depletion effects on membrane 20 4.92E-6
3 SGTC_2781 5567276 4.27 71.4 µM 2.09E-6 39 9.85E-6
4 SGTC_3207 9114163 4.16 49.5 µM 3.67E-6 24 1.61E-5
5 SGTC_1917 st066507 4.09 28.5 µM 5.02E-6 Golgi 31 2.11E-5
6 SGTC_1733 st037357 3.85 54.9 µM 1.62E-5 60S ribosome export 31 5.88E-5
7 SGTC_2565 isoliquiritigenin 3.84 100.0 µM 1.74E-5 38 6.27E-5
8 SGTC_895 0964-0006 3.73 13.7 µM 2.81E-5 19 9.51E-5
9 SGTC_1532 4',5'-dihydroxyflavone 3.36 78.7 µM 1.42E-4 Golgi 35 3.92E-4
10 SGTC_624 k048-0052 3.15 28.0 µM 3.32E-4 Golgi 43 8.23E-4
11 SGTC_1449 4112-4002 3.13 201.0 µM 3.49E-4 RPP1 & pyrimidine depletion 38 8.60E-4
12 SGTC_665 3914-0008 3.13 307.0 µM 3.63E-4 46 8.89E-4
13 SGTC_891 0929-0073 3.07 133.0 µM 4.41E-4 59 0.00105
14 SGTC_2960 9079389 2.99 6.0 µM 6.10E-4 70 0.00140
15 SGTC_622 1348-1566 2.97 26.3 µM 6.47E-4 63 0.00147
16 SGTC_890 0929-0006 2.96 47.2 µM 6.73E-4 58 0.00152
17 SGTC_1754 st042065 2.93 16.1 µM 7.47E-4 NEO1-PIK1 273 0.00167
18 SGTC_1306 1185-0270 2.93 9.0 µM 7.70E-4 Golgi 93 0.00172
19 SGTC_2434 5670830 2.90 169.9 µM 8.43E-4 84 0.00186
20 SGTC_1510 1123-0200 2.88 71.5 µM 8.96E-4 108 0.00196

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 4.27E-19 YPL199C_p YPL199C_p hom Putative protein of unknown function, predicted to be palmitoylated
0.133 9.87E-15 YOL079W_d YOL079W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.121 2.15E-12 YDR259C YAP6 hom Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication
0.113 5.23E-11 YGR242W_d YGR242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
0.105 1.26E-9 YER008C SEC3 het Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress
0.094 4.73E-8 YGL051W MST27 hom Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
0.094 5.58E-8 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.093 6.52E-8 YOR094W ARF3 hom Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity
0.093 6.68E-8 YCR072C RSA4 het WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
0.090 1.80E-7 YPR055W SEC8 het Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress
0.089 2.08E-7 YKL142W MRP8 hom Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis
0.089 2.14E-7 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family
0.086 6.20E-7 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.086 6.30E-7 YLR136C TIS11 hom mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.083 1.42E-6 YIL155C GUT2 hom Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner