YLR365W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR365W / YLR365W

Click on Significant Values for Screen Details ID:SGTC_230|Compound:MPP+|FD-Score:2.95|P-value:3.91E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:2.76|P-value:8.19E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.23|P-value:1.17E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:-2.97|P-value:4.04E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:-4.27|P-value:7.28E-7 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.61|P-value:1.99E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.33|P-value:7.46E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:2.72|P-value:9.61E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:-3.09|P-value:2.46E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.10|P-value:2.11E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.13|P-value:1.82E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.17|P-value:1.57E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.10|P-value:2.05E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.53|P-value:3.01E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.18|P-value:1.49E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:-2.76|P-value:9.32E-4 ID:SGTC_1594|Compound:piperine|FD-Score:-3.33|P-value:8.60E-5 ID:SGTC_1638|Compound:st008370|FD-Score:-2.84|P-value:6.91E-4 ID:SGTC_1702|Compound:st027038|FD-Score:2.90|P-value:4.79E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.34|P-value:7.37E-5 ID:SGTC_1899|Compound:st063254|FD-Score:-2.85|P-value:6.54E-4 ID:SGTC_2028|Compound:5153890|FD-Score:-3.16|P-value:1.82E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-3.69|P-value:1.57E-5 ID:SGTC_2121|Compound:5257820|FD-Score:3.22|P-value:1.23E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.24|P-value:1.15E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.74|P-value:1.04E-5 ID:SGTC_2303|Compound:7774051|FD-Score:2.75|P-value:8.83E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.53|P-value:2.90E-5 ID:SGTC_2318|Compound:6029776|FD-Score:5.58|P-value:1.21E-10 ID:SGTC_2329|Compound:6138490|FD-Score:4.75|P-value:3.29E-8 ID:SGTC_2342|Compound:7990637|FD-Score:-3.19|P-value:1.61E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.05|P-value:2.58E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.01|P-value:3.06E-4 ID:SGTC_2411|Compound:st077133|FD-Score:6.00|P-value:4.83E-12 ID:SGTC_2412|Compound:st077135|FD-Score:3.37|P-value:6.38E-5 ID:SGTC_2413|Compound:inermin|FD-Score:3.05|P-value:2.60E-4 ID:SGTC_2450|Compound:5739737|FD-Score:2.88|P-value:5.12E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:2.98|P-value:3.46E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-2.88|P-value:5.88E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:2.74|P-value:8.85E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.27|P-value:1.15E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.20|P-value:1.55E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-2.86|P-value:6.29E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-4.23|P-value:9.14E-7 ID:SGTC_3068|Compound:9116768|FD-Score:2.99|P-value:3.36E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.85|P-value:6.99E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-4.36|P-value:4.34E-7 ID:SGTC_230|Compound:MPP+|FD-Score:2.95|P-value:3.91E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:2.76|P-value:8.19E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.23|P-value:1.17E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:-2.97|P-value:4.04E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:-4.27|P-value:7.28E-7 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.61|P-value:1.99E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.33|P-value:7.46E-5 ID:SGTC_539|Compound:4859-0462|FD-Score:2.72|P-value:9.61E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:-3.09|P-value:2.46E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.10|P-value:2.11E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.13|P-value:1.82E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.17|P-value:1.57E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.10|P-value:2.05E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.53|P-value:3.01E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.18|P-value:1.49E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:-2.76|P-value:9.32E-4 ID:SGTC_1594|Compound:piperine|FD-Score:-3.33|P-value:8.60E-5 ID:SGTC_1638|Compound:st008370|FD-Score:-2.84|P-value:6.91E-4 ID:SGTC_1702|Compound:st027038|FD-Score:2.90|P-value:4.79E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.34|P-value:7.37E-5 ID:SGTC_1899|Compound:st063254|FD-Score:-2.85|P-value:6.54E-4 ID:SGTC_2028|Compound:5153890|FD-Score:-3.16|P-value:1.82E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-3.69|P-value:1.57E-5 ID:SGTC_2121|Compound:5257820|FD-Score:3.22|P-value:1.23E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.24|P-value:1.15E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.74|P-value:1.04E-5 ID:SGTC_2303|Compound:7774051|FD-Score:2.75|P-value:8.83E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.53|P-value:2.90E-5 ID:SGTC_2318|Compound:6029776|FD-Score:5.58|P-value:1.21E-10 ID:SGTC_2329|Compound:6138490|FD-Score:4.75|P-value:3.29E-8 ID:SGTC_2342|Compound:7990637|FD-Score:-3.19|P-value:1.61E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.05|P-value:2.58E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.01|P-value:3.06E-4 ID:SGTC_2411|Compound:st077133|FD-Score:6.00|P-value:4.83E-12 ID:SGTC_2412|Compound:st077135|FD-Score:3.37|P-value:6.38E-5 ID:SGTC_2413|Compound:inermin|FD-Score:3.05|P-value:2.60E-4 ID:SGTC_2450|Compound:5739737|FD-Score:2.88|P-value:5.12E-4 ID:SGTC_2491|Compound:paeonol|FD-Score:2.98|P-value:3.46E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-2.88|P-value:5.88E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:2.74|P-value:8.85E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.27|P-value:1.15E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.20|P-value:1.55E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-2.86|P-value:6.29E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-4.23|P-value:9.14E-7 ID:SGTC_3068|Compound:9116768|FD-Score:2.99|P-value:3.36E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.85|P-value:6.99E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-4.36|P-value:4.34E-7

Top fitness defect scores for YLR365W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2411 st077133 6.00 39.9 µM 4.83E-12 RNA pol III & RNase P/MRP 6 9.92E-10
2 SGTC_2318 6029776 5.58 164.0 µM 1.21E-10 8 1.23E-8
3 SGTC_2329 6138490 4.75 200.0 µM 3.29E-8 13 9.93E-7
4 SGTC_2282 7944268 3.74 200.0 µM 1.04E-5 RPP1 & pyrimidine depletion 39 9.09E-5
5 SGTC_410 α-linolenic acid 3.61 100.0 µM 1.99E-5 excess fatty acid 47 1.52E-4
6 SGTC_2309 7664088 3.53 163.9 µM 2.90E-5 59 2.04E-4
7 SGTC_989 1501-0895 3.53 10.3 µM 3.01E-5 15 2.10E-4
8 SGTC_2412 st077135 3.37 33.4 µM 6.38E-5 46 3.80E-4
9 SGTC_1878 temozolomide 3.34 1.0 mM 7.37E-5 21 4.25E-4
10 SGTC_420 mitomycin C 3.33 81.9 mM 7.46E-5 31 4.30E-4
11 SGTC_2177 5811945 3.24 192.0 µM 1.15E-4 50 6.03E-4
12 SGTC_290 2043-6722 3.23 48.1 µM 1.17E-4 36 6.11E-4
13 SGTC_2121 5257820 3.22 149.6 µM 1.23E-4 31 6.38E-4
14 SGTC_1099 5-nonyloxytryptamine 3.18 2.9 µM 1.49E-4 51 7.40E-4
15 SGTC_631 k072-0230 3.17 41.5 µM 1.57E-4 60S ribosome export 52 7.71E-4
16 SGTC_628 1636-0253 3.13 16.0 µM 1.82E-4 sphingolipid biosynthesis & PDR1 68 8.68E-4
17 SGTC_939 1165-0479 3.10 45.3 µM 2.05E-4 76 9.53E-4
18 SGTC_626 0214-0009 3.10 33.0 µM 2.11E-4 copper-dependent oxidative stress 56 9.77E-4
19 SGTC_2398 5228213 3.05 48.8 µM 2.58E-4 iron homeostasis 102 0.00114
20 SGTC_2413 inermin 3.05 26.1 µM 2.60E-4 98 0.00115

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.157 7.19E-20 YOR177C MPC54 hom Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate
0.152 9.04E-19 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.126 2.43E-13 YOR260W GCD1 het Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.121 2.19E-12 YNL260C LTO1 het Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
0.118 5.73E-12 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.114 3.32E-11 YIR016W_p YIR016W_p hom Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication
0.111 1.14E-10 YGR083C GCD2 het Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.105 1.06E-9 YLR327C TMA10 hom Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress
0.100 6.91E-9 YMR310C_p YMR310C_p hom Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene
0.096 2.22E-8 YHR087W RTC3 hom Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress
0.096 3.01E-8 YMR283C RIT1 hom 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA
0.095 3.04E-8 YKL034W TUL1 hom Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1
0.094 5.08E-8 YLR444C_d YLR444C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.094 5.38E-8 YBR150C TBS1 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication
0.094 5.37E-8 YIL164C NIT1 hom Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene