HIPHOP chemogenomics database

YLR367W / RPS22B

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR367W / RPS22B

Click on Significant Values for Screen Details

Top fitness defect scores for YLR367W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2688	kanamycin b	5.76	96.7 µM	1.79E-9	calcium & mitochondrial duress	172	4.31E-9
2	SGTC_1302	1159-0335	4.49	255.0 µM	2.08E-6		6	3.64E-6
3	SGTC_3324	9138759	4.44	60.8 µM	2.64E-6		11	4.58E-6
4	SGTC_1880	MG-132	3.98	525.0 µM	2.22E-5		17	3.48E-5
5	SGTC_405	ebelactone b	3.91	50.0 µM	3.00E-5		18	4.65E-5
6	SGTC_1249	0481-0015	3.67	10.2 µM	8.10E-5		32	1.20E-4
7	SGTC_2287	7945887	3.60	168.8 µM	1.08E-4		12	1.57E-4
8	SGTC_3268	9137683	3.58	49.5 µM	1.19E-4		13	1.74E-4
9	SGTC_1375	2910-0797	3.54	186.0 µM	1.37E-4		39	1.99E-4
10	SGTC_130	0136-0219	3.53	337.7 µM	1.44E-4		35	2.07E-4
11	SGTC_2281	7943571	3.41	200.0 µM	2.32E-4		22	3.28E-4
12	SGTC_2398	5228213	3.39	48.8 µM	2.50E-4	iron homeostasis	69	3.52E-4
13	SGTC_2587	piperic acid	3.34	92.2 µM	2.98E-4		40	4.16E-4
14	SGTC_3055	9094636	3.31	49.5 µM	3.39E-4		27	4.70E-4
15	SGTC_2580	diallyl disulphide	3.30	81.4 µM	3.52E-4		40	4.88E-4
16	SGTC_2996	9066192	3.30	71.4 µM	3.53E-4		67	4.89E-4
17	SGTC_746	1095-0025	3.29	46.6 µM	3.62E-4	RSC & ERG11	33	5.01E-4
18	SGTC_2054	5233173	3.21	129.0 µM	4.84E-4	mitochondrial response to ROS	96	6.61E-4
19	SGTC_305	1682-2595	3.15	20.8 µM	5.98E-4	RNA processing & uracil transport	47	8.09E-4
20	SGTC_3175	9106517	3.13	49.5 µM	6.59E-4	iron homeostasis	43	8.87E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.255	6.45E-51	YDL037C	BSC1	hom	Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.245	5.42E-47	YGR159C	NSR1	hom	Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.224	3.04E-39	YDR447C	RPS17B	hom	Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.223	4.90E-39	YGR214W	RPS0A	hom	Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;
0.217	3.60E-37	YNR044W	AGA1	hom	Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.202	2.73E-32	YLL045C	RPL8B	hom	Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.202	3.73E-32	YBR048W	RPS11B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication
0.196	1.89E-30	YDL052C	SLC1	hom	1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes
0.192	3.36E-29	YDR398W	UTP5	het	Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.187	8.71E-28	YNL067W	RPL9B	hom	Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.181	5.42E-26	YIL042C	PKP1	hom	Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
0.181	5.71E-26	YDL110C	TMA17	hom	Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.174	3.17E-24	YDR317W	HIM1	hom	Protein of unknown function involved in DNA repair
0.165	5.99E-22	YIL121W	QDR2	hom	Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper
0.162	3.96E-21	YER017C	AFG3	hom	Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease; mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging