YLR368W / MDM30

F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR368W / MDM30

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:5.66|P-value:6.54E-9 ID:SGTC_43|Compound:0570-0105|FD-Score:-5.47|P-value:2.81E-8 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.18|P-value:8.35E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.29|P-value:4.46E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.08|P-value:1.65E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:4.07|P-value:2.11E-5 ID:SGTC_338|Compound:4055-0136|FD-Score:-3.66|P-value:1.43E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:3.22|P-value:5.83E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.28|P-value:4.76E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:4.26|P-value:9.13E-6 ID:SGTC_722|Compound:3534-0461|FD-Score:3.71|P-value:9.39E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:-3.53|P-value:2.32E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.24|P-value:5.31E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.25|P-value:6.56E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.08|P-value:9.40E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.95|P-value:3.42E-5 ID:SGTC_1635|Compound:st007035|FD-Score:-3.50|P-value:2.66E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.65|P-value:1.17E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.18|P-value:6.55E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.69|P-value:1.61E-6 ID:SGTC_1843|Compound:st055809|FD-Score:4.49|P-value:3.18E-6 ID:SGTC_1850|Compound:st056238|FD-Score:3.33|P-value:3.87E-4 ID:SGTC_1853|Compound:st056710|FD-Score:-3.34|P-value:4.69E-4 ID:SGTC_1855|Compound:st056195|FD-Score:-3.41|P-value:3.67E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.15|P-value:7.38E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.27|P-value:4.86E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.69|P-value:1.01E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.07|P-value:9.79E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-3.77|P-value:9.22E-5 ID:SGTC_2321|Compound:7390090|FD-Score:-4.99|P-value:3.71E-7 ID:SGTC_2327|Compound:6189656|FD-Score:6.08|P-value:4.94E-10 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.88|P-value:5.89E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.78|P-value:8.85E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.45|P-value:2.56E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.37|P-value:4.17E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.55|P-value:2.39E-6 ID:SGTC_2873|Compound:9040596|FD-Score:4.79|P-value:7.33E-7 ID:SGTC_2890|Compound:9046729|FD-Score:3.25|P-value:5.30E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-5.88|P-value:2.55E-9 ID:SGTC_3220|Compound:9131269|FD-Score:-5.10|P-value:1.99E-7 ID:SGTC_3222|Compound:9128301|FD-Score:-5.90|P-value:2.30E-9 ID:SGTC_3268|Compound:9137683|FD-Score:-3.79|P-value:8.62E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.08|P-value:9.30E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.34|P-value:3.84E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.74|P-value:8.12E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:5.66|P-value:6.54E-9 ID:SGTC_43|Compound:0570-0105|FD-Score:-5.47|P-value:2.81E-8 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.18|P-value:8.35E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.29|P-value:4.46E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.08|P-value:1.65E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:4.07|P-value:2.11E-5 ID:SGTC_338|Compound:4055-0136|FD-Score:-3.66|P-value:1.43E-4 ID:SGTC_492|Compound:tmb-8|FD-Score:3.22|P-value:5.83E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:3.28|P-value:4.76E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:4.26|P-value:9.13E-6 ID:SGTC_722|Compound:3534-0461|FD-Score:3.71|P-value:9.39E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:-3.53|P-value:2.32E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.24|P-value:5.31E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.25|P-value:6.56E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.08|P-value:9.40E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.95|P-value:3.42E-5 ID:SGTC_1635|Compound:st007035|FD-Score:-3.50|P-value:2.66E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.65|P-value:1.17E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.18|P-value:6.55E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.69|P-value:1.61E-6 ID:SGTC_1843|Compound:st055809|FD-Score:4.49|P-value:3.18E-6 ID:SGTC_1850|Compound:st056238|FD-Score:3.33|P-value:3.87E-4 ID:SGTC_1853|Compound:st056710|FD-Score:-3.34|P-value:4.69E-4 ID:SGTC_1855|Compound:st056195|FD-Score:-3.41|P-value:3.67E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.15|P-value:7.38E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.27|P-value:4.86E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.69|P-value:1.01E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.07|P-value:9.79E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-3.77|P-value:9.22E-5 ID:SGTC_2321|Compound:7390090|FD-Score:-4.99|P-value:3.71E-7 ID:SGTC_2327|Compound:6189656|FD-Score:6.08|P-value:4.94E-10 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.88|P-value:5.89E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.78|P-value:8.85E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.45|P-value:2.56E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.37|P-value:4.17E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.55|P-value:2.39E-6 ID:SGTC_2873|Compound:9040596|FD-Score:4.79|P-value:7.33E-7 ID:SGTC_2890|Compound:9046729|FD-Score:3.25|P-value:5.30E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-5.88|P-value:2.55E-9 ID:SGTC_3220|Compound:9131269|FD-Score:-5.10|P-value:1.99E-7 ID:SGTC_3222|Compound:9128301|FD-Score:-5.90|P-value:2.30E-9 ID:SGTC_3268|Compound:9137683|FD-Score:-3.79|P-value:8.62E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.08|P-value:9.30E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.34|P-value:3.84E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.74|P-value:8.12E-5

Top fitness defect scores for YLR368W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2327 6189656 6.08 200.0 µM 4.94E-10 2 5.85E-10
2 SGTC_35 0133-0054 5.66 64.1 µM 6.54E-9 5 7.67E-9
3 SGTC_173 1273-0061 5.08 2.7 µM 1.65E-7 mitochondrial stress 143 1.91E-7
4 SGTC_2873 9040596 4.79 71.4 µM 7.33E-7 26 8.43E-7
5 SGTC_2751 anetholtrithion 4.55 17.2 µM 2.39E-6 17 2.74E-6
6 SGTC_1843 st055809 4.49 45.5 µM 3.18E-6 9 3.63E-6
7 SGTC_603 3794-0023 4.26 45.9 µM 9.13E-6 7 1.04E-5
8 SGTC_310 1273-0058 4.07 1.1 µM 2.11E-5 mitochondrial stress 237 2.39E-5
9 SGTC_1629 st005085 3.95 44.9 µM 3.42E-5 RPP1 & pyrimidine depletion 37 3.85E-5
10 SGTC_3354 9151612 3.74 71.4 µM 8.12E-5 15 9.11E-5
11 SGTC_722 3534-0461 3.71 190.0 µM 9.39E-5 PDR1 46 1.05E-4
12 SGTC_2106 5357045 3.69 167.3 µM 1.01E-4 26 1.14E-4
13 SGTC_1693 xanthone 3.65 101.9 µM 1.17E-4 DNA damage response 23 1.30E-4
14 SGTC_2598 perillyl alcohol 3.45 100.0 µM 2.56E-4 55 2.85E-4
15 SGTC_3336 9143619 3.34 71.4 µM 3.84E-4 39 4.26E-4
16 SGTC_1850 st056238 3.33 17.0 µM 3.87E-4 RPP1 & pyrimidine depletion 40 4.29E-4
17 SGTC_93 0109-0045 3.29 59.2 µM 4.46E-4 DNA damage response 72 4.94E-4
18 SGTC_593 1203-0218 3.28 61.7 µM 4.76E-4 26 5.27E-4
19 SGTC_1889 st059080 3.27 5.2 µM 4.86E-4 44 5.38E-4
20 SGTC_2890 9046729 3.25 58.4 µM 5.30E-4 Golgi 39 5.87E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 4.88E-16 YHR168W MTG2 hom Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
0.136 3.20E-15 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.134 8.27E-15 YHR011W DIA4 hom Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth
0.132 2.17E-14 YMR293C HER2 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase
0.131 2.49E-14 YDR519W FPR2 hom Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress
0.127 1.34E-13 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.126 3.06E-13 YKL138C MRPL31 hom Mitochondrial ribosomal protein of the large subunit
0.125 4.06E-13 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.124 5.43E-13 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.123 7.93E-13 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.122 1.35E-12 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.119 4.68E-12 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.117 8.67E-12 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.117 1.18E-11 YDR507C GIN4 hom Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication
0.113 5.14E-11 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport