YLR381W / CTF3

Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR381W / CTF3

Click on Significant Values for Screen Details ID:SGTC_86|Compound:0417-1630|FD-Score:3.40|P-value:1.31E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.13|P-value:3.77E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-5.62|P-value:1.68E-9 ID:SGTC_259|Compound:usnic acid|FD-Score:3.28|P-value:2.10E-4 ID:SGTC_277|Compound:nystatin|FD-Score:2.89|P-value:9.22E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.84|P-value:1.89E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:3.68|P-value:3.90E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:2.97|P-value:7.12E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.19|P-value:4.28E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.25|P-value:3.44E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.00|P-value:6.17E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.80|P-value:3.43E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:3.07|P-value:4.92E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.13|P-value:3.90E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:5.49|P-value:2.25E-9 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.84|P-value:1.94E-5 ID:SGTC_1410|Compound:3909-8106|FD-Score:2.89|P-value:9.25E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.75|P-value:2.88E-5 ID:SGTC_1683|Compound:st010134|FD-Score:3.02|P-value:5.83E-4 ID:SGTC_1699|Compound:st031318|FD-Score:4.30|P-value:2.08E-6 ID:SGTC_1712|Compound:st032288|FD-Score:4.12|P-value:5.18E-6 ID:SGTC_1754|Compound:st042065|FD-Score:6.37|P-value:5.14E-12 ID:SGTC_1763|Compound:st044482|FD-Score:-3.31|P-value:2.68E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.38|P-value:1.40E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.37|P-value:1.50E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.23|P-value:2.56E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.02|P-value:5.89E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.05|P-value:5.22E-4 ID:SGTC_1896|Compound:st058441|FD-Score:3.58|P-value:6.00E-5 ID:SGTC_2040|Compound:5100729|FD-Score:3.16|P-value:3.46E-4 ID:SGTC_2177|Compound:5811945|FD-Score:2.94|P-value:7.72E-4 ID:SGTC_2219|Compound:9098279|FD-Score:3.14|P-value:3.73E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.03|P-value:5.51E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-3.14|P-value:5.18E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-3.65|P-value:6.49E-5 ID:SGTC_2344|Compound:7990960|FD-Score:-5.86|P-value:3.42E-10 ID:SGTC_2350|Compound:9023895|FD-Score:-7.17|P-value:2.06E-14 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.18|P-value:4.37E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.26|P-value:2.35E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:5.11|P-value:2.40E-8 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.56|P-value:6.54E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.10|P-value:4.23E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.17|P-value:3.34E-4 ID:SGTC_2883|Compound:9059145|FD-Score:-4.83|P-value:2.00E-7 ID:SGTC_2993|Compound:9054257|FD-Score:3.32|P-value:1.79E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.63|P-value:4.92E-5 ID:SGTC_3030|Compound:9087619|FD-Score:3.19|P-value:3.08E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.99|P-value:9.56E-6 ID:SGTC_3284|Compound:9108171|FD-Score:2.93|P-value:7.98E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.40|P-value:1.31E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.13|P-value:3.77E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-5.62|P-value:1.68E-9 ID:SGTC_259|Compound:usnic acid|FD-Score:3.28|P-value:2.10E-4 ID:SGTC_277|Compound:nystatin|FD-Score:2.89|P-value:9.22E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.84|P-value:1.89E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:3.68|P-value:3.90E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:2.97|P-value:7.12E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-3.19|P-value:4.28E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.25|P-value:3.44E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.00|P-value:6.17E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:-3.80|P-value:3.43E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:3.07|P-value:4.92E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.13|P-value:3.90E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:5.49|P-value:2.25E-9 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.84|P-value:1.94E-5 ID:SGTC_1410|Compound:3909-8106|FD-Score:2.89|P-value:9.25E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.75|P-value:2.88E-5 ID:SGTC_1683|Compound:st010134|FD-Score:3.02|P-value:5.83E-4 ID:SGTC_1699|Compound:st031318|FD-Score:4.30|P-value:2.08E-6 ID:SGTC_1712|Compound:st032288|FD-Score:4.12|P-value:5.18E-6 ID:SGTC_1754|Compound:st042065|FD-Score:6.37|P-value:5.14E-12 ID:SGTC_1763|Compound:st044482|FD-Score:-3.31|P-value:2.68E-4 ID:SGTC_1764|Compound:st044502|FD-Score:3.38|P-value:1.40E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.37|P-value:1.50E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.23|P-value:2.56E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.02|P-value:5.89E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.05|P-value:5.22E-4 ID:SGTC_1896|Compound:st058441|FD-Score:3.58|P-value:6.00E-5 ID:SGTC_2040|Compound:5100729|FD-Score:3.16|P-value:3.46E-4 ID:SGTC_2177|Compound:5811945|FD-Score:2.94|P-value:7.72E-4 ID:SGTC_2219|Compound:9098279|FD-Score:3.14|P-value:3.73E-4 ID:SGTC_2277|Compound:7947813|FD-Score:3.03|P-value:5.51E-4 ID:SGTC_2342|Compound:7990637|FD-Score:-3.14|P-value:5.18E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-3.65|P-value:6.49E-5 ID:SGTC_2344|Compound:7990960|FD-Score:-5.86|P-value:3.42E-10 ID:SGTC_2350|Compound:9023895|FD-Score:-7.17|P-value:2.06E-14 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.18|P-value:4.37E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.26|P-value:2.35E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:5.11|P-value:2.40E-8 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.56|P-value:6.54E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.10|P-value:4.23E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.17|P-value:3.34E-4 ID:SGTC_2883|Compound:9059145|FD-Score:-4.83|P-value:2.00E-7 ID:SGTC_2993|Compound:9054257|FD-Score:3.32|P-value:1.79E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.63|P-value:4.92E-5 ID:SGTC_3030|Compound:9087619|FD-Score:3.19|P-value:3.08E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.99|P-value:9.56E-6 ID:SGTC_3284|Compound:9108171|FD-Score:2.93|P-value:7.98E-4

Top fitness defect scores for YLR381W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1754 st042065 6.37 16.1 µM 5.14E-12 NEO1-PIK1 87 9.23E-11
2 SGTC_951 1171-0579 5.49 82.7 µM 2.25E-9 cell wall 39 2.02E-8
3 SGTC_2755 lomerizine 5.11 42.7 µM 2.40E-8 9 1.64E-7
4 SGTC_1699 st031318 4.30 29.1 µM 2.08E-6 20 8.59E-6
5 SGTC_1712 st032288 4.12 53.4 µM 5.18E-6 calcium & mitochondrial duress 180 1.92E-5
6 SGTC_3180 9109287 3.99 49.5 µM 9.56E-6 11 3.31E-5
7 SGTC_314 1671-0008 3.84 2.7 µM 1.89E-5 58 6.06E-5
8 SGTC_1032 k061-1018 3.84 98.7 µM 1.94E-5 25 6.20E-5
9 SGTC_1456 k015-0012 3.75 13.0 µM 2.88E-5 37 8.80E-5
10 SGTC_320 4092-0846 3.68 5.3 µM 3.90E-5 ergosterol depletion effects on membrane 61 1.15E-4
11 SGTC_3020 9089140 3.63 49.5 µM 4.92E-5 35 1.42E-4
12 SGTC_1896 st058441 3.58 89.0 µM 6.00E-5 23 1.69E-4
13 SGTC_2757 clomiphene 3.56 4.2 µM 6.54E-5 fatty acid desaturase (OLE1) 53 1.82E-4
14 SGTC_86 0417-1630 3.40 471.9 µM 1.31E-4 ubiquinone biosynthesis & proteasome 185 3.37E-4
15 SGTC_1764 st044502 3.38 93.5 µM 1.40E-4 42 3.56E-4
16 SGTC_1833 st055984 3.37 71.0 µM 1.50E-4 31 3.79E-4
17 SGTC_2993 9054257 3.32 71.4 µM 1.79E-4 fatty acid desaturase (OLE1) 73 4.43E-4
18 SGTC_259 usnic acid 3.28 108.9 µM 2.10E-4 41 5.12E-4
19 SGTC_2703 st077852 3.26 53.4 µM 2.35E-4 54 5.66E-4
20 SGTC_1886 st057356 3.23 49.9 µM 2.56E-4 60S ribosome export 40 6.09E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 6.58E-17 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.119 5.44E-12 YOR245C DGA1 hom Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles
0.118 8.09E-12 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.114 3.23E-11 YPL169C MEX67 het Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP
0.109 2.52E-10 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.106 6.67E-10 YDR491C_d YDR491C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.103 1.99E-9 YOR034C AKR2 hom Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication
0.103 2.42E-9 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.101 4.10E-9 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.099 1.01E-8 YML106W URA5 hom Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication
0.098 1.13E-8 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.098 1.25E-8 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.095 3.40E-8 YMR273C ZDS1 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication
0.093 7.12E-8 YNL070W TOM7 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.092 9.05E-8 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins