YLR410W / VIP1

Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR410W / VIP1

Click on Significant Values for Screen Details ID:SGTC_2|Compound:0422-0095|FD-Score:3.66|P-value:4.21E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:-3.10|P-value:5.08E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.37|P-value:1.48E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.18|P-value:3.83E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.60|P-value:6.68E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:-3.77|P-value:3.24E-5 ID:SGTC_338|Compound:4055-0136|FD-Score:-4.55|P-value:6.64E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.57|P-value:7.56E-5 ID:SGTC_629|Compound:3448-6466|FD-Score:2.94|P-value:7.88E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-2.95|P-value:8.81E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.20|P-value:2.89E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.04|P-value:6.50E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.97|P-value:1.26E-5 ID:SGTC_898|Compound:1000-0849|FD-Score:3.23|P-value:2.60E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.57|P-value:7.67E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:3.15|P-value:3.52E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.03|P-value:6.72E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.09|P-value:5.36E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-4.16|P-value:5.00E-6 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.52|P-value:7.85E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.94|P-value:1.17E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:2.90|P-value:9.11E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.35|P-value:1.56E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.28|P-value:2.17E-6 ID:SGTC_1716|Compound:st033144|FD-Score:3.82|P-value:2.03E-5 ID:SGTC_1721|Compound:st082152|FD-Score:-3.57|P-value:7.54E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-3.22|P-value:3.16E-4 ID:SGTC_1837|Compound:st055472|FD-Score:2.97|P-value:7.07E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.36|P-value:1.50E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.98|P-value:8.05E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-2.99|P-value:7.85E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.40|P-value:1.30E-4 ID:SGTC_2096|Compound:5468907|FD-Score:3.73|P-value:3.03E-5 ID:SGTC_2246|Compound:7293507|FD-Score:3.19|P-value:3.01E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.69|P-value:4.61E-5 ID:SGTC_2450|Compound:5739737|FD-Score:-3.57|P-value:7.73E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.25|P-value:2.83E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.06|P-value:5.01E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.11|P-value:5.09E-6 ID:SGTC_2797|Compound:7859098|FD-Score:-4.26|P-value:3.12E-6 ID:SGTC_2939|Compound:9044578|FD-Score:-2.98|P-value:7.95E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.65|P-value:4.37E-5 ID:SGTC_3285|Compound:9112818|FD-Score:-3.56|P-value:7.97E-5 ID:SGTC_3287|Compound:9117173|FD-Score:3.16|P-value:3.43E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.51|P-value:8.17E-5 ID:SGTC_2|Compound:0422-0095|FD-Score:3.66|P-value:4.21E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:-3.10|P-value:5.08E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.37|P-value:1.48E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.18|P-value:3.83E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.60|P-value:6.68E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:-3.77|P-value:3.24E-5 ID:SGTC_338|Compound:4055-0136|FD-Score:-4.55|P-value:6.64E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.57|P-value:7.56E-5 ID:SGTC_629|Compound:3448-6466|FD-Score:2.94|P-value:7.88E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:-2.95|P-value:8.81E-4 ID:SGTC_641|Compound:4092-0595|FD-Score:3.20|P-value:2.89E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.04|P-value:6.50E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.97|P-value:1.26E-5 ID:SGTC_898|Compound:1000-0849|FD-Score:3.23|P-value:2.60E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.57|P-value:7.67E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:3.15|P-value:3.52E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.03|P-value:6.72E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.09|P-value:5.36E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-4.16|P-value:5.00E-6 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.52|P-value:7.85E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.94|P-value:1.17E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:2.90|P-value:9.11E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.35|P-value:1.56E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.28|P-value:2.17E-6 ID:SGTC_1716|Compound:st033144|FD-Score:3.82|P-value:2.03E-5 ID:SGTC_1721|Compound:st082152|FD-Score:-3.57|P-value:7.54E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-3.22|P-value:3.16E-4 ID:SGTC_1837|Compound:st055472|FD-Score:2.97|P-value:7.07E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.36|P-value:1.50E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.98|P-value:8.05E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-2.99|P-value:7.85E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.40|P-value:1.30E-4 ID:SGTC_2096|Compound:5468907|FD-Score:3.73|P-value:3.03E-5 ID:SGTC_2246|Compound:7293507|FD-Score:3.19|P-value:3.01E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.69|P-value:4.61E-5 ID:SGTC_2450|Compound:5739737|FD-Score:-3.57|P-value:7.73E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.25|P-value:2.83E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.06|P-value:5.01E-4 ID:SGTC_2794|Compound:7785382|FD-Score:4.11|P-value:5.09E-6 ID:SGTC_2797|Compound:7859098|FD-Score:-4.26|P-value:3.12E-6 ID:SGTC_2939|Compound:9044578|FD-Score:-2.98|P-value:7.95E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.65|P-value:4.37E-5 ID:SGTC_3285|Compound:9112818|FD-Score:-3.56|P-value:7.97E-5 ID:SGTC_3287|Compound:9117173|FD-Score:3.16|P-value:3.43E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.51|P-value:8.17E-5

Top fitness defect scores for YLR410W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1679 4130-1276 4.28 6.7 µM 2.17E-6 Golgi 51 9.31E-6
2 SGTC_2794 7785382 4.11 27.3 µM 5.09E-6 31 1.97E-5
3 SGTC_1181 1222-0449 3.94 220.0 µM 1.17E-5 27 4.08E-5
4 SGTC_1716 st033144 3.82 30.6 µM 2.03E-5 26 6.63E-5
5 SGTC_2096 5468907 3.73 200.0 µM 3.03E-5 11 9.43E-5
6 SGTC_2 0422-0095 3.66 29.0 µM 4.21E-5 redox potentiating 11 1.26E-4
7 SGTC_3065 9113888 3.65 49.5 µM 4.37E-5 32 1.30E-4
8 SGTC_1176 0848-0131 3.52 83.3 µM 7.85E-5 Golgi 32 2.18E-4
9 SGTC_3315 9136395 3.51 68.5 µM 8.17E-5 19 2.26E-4
10 SGTC_2093 5331342 3.40 194.4 µM 1.30E-4 37 3.40E-4
11 SGTC_255 tunicamycin 3.37 200.5 nM 1.48E-4 unfolded protein response 102 3.80E-4
12 SGTC_1899 st063254 3.36 59.6 µM 1.50E-4 26 3.86E-4
13 SGTC_1261 0712-0010 3.35 12.7 µM 1.56E-4 RNA processing & uracil transport 46 3.97E-4
14 SGTC_898 1000-0849 3.23 28.3 µM 2.60E-4 21 6.23E-4
15 SGTC_641 4092-0595 3.20 30.0 µM 2.89E-4 32 6.84E-4
16 SGTC_2246 7293507 3.19 91.6 µM 3.01E-4 63 7.09E-4
17 SGTC_3287 9117173 3.16 37.1 µM 3.43E-4 60S ribosome export 18 7.98E-4
18 SGTC_1123 mangostin 3.15 811.3 nM 3.52E-4 mitochondrial response to ROS 68 8.15E-4
19 SGTC_2602 kawain 3.06 100.0 µM 5.01E-4 73 0.00111
20 SGTC_1837 st055472 2.97 66.5 µM 7.07E-4 56 0.00151

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.161 7.51E-21 YFR027W ECO1 het Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress
0.125 4.44E-13 YOR084W LPX1 hom Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
0.124 4.87E-13 YAL068C PAU8 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions
0.118 5.79E-12 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.118 6.78E-12 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.115 2.83E-11 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.113 5.18E-11 YML070W DAK1 hom Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
0.111 9.84E-11 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.110 1.98E-10 YMR129W POM152 hom Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210
0.109 2.42E-10 YLR290C_p YLR290C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene
0.106 8.24E-10 YDR044W HEM13 het Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
0.105 1.14E-9 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.102 2.75E-9 YOR082C_d YOR082C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
0.102 3.33E-9 YJR092W BUD4 hom Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p
0.102 3.43E-9 YER062C HOR2 hom Glycerol-1-phosphatase involved in glycerol biosynthesis; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; HOR2 has a paralog, RHR2, that arose from the whole genome duplication