YLR429W / CRN1

Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR429W / CRN1

Click on Significant Values for Screen Details ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:-2.77|P-value:9.17E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.11|P-value:2.41E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.55|P-value:4.29E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-2.76|P-value:9.64E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:3.23|P-value:1.79E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:-3.02|P-value:3.49E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.86|P-value:9.37E-6 ID:SGTC_472|Compound:calcifediol|FD-Score:3.11|P-value:2.92E-4 ID:SGTC_489|Compound:paxilline|FD-Score:2.90|P-value:6.69E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:2.92|P-value:6.14E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.31|P-value:1.28E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.04|P-value:3.95E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:-3.12|P-value:2.24E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:-2.79|P-value:8.66E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:-2.88|P-value:6.10E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.05|P-value:3.68E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:2.93|P-value:5.89E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:2.94|P-value:5.75E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.06|P-value:3.53E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.42|P-value:7.82E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.73|P-value:1.82E-5 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.33|P-value:8.01E-7 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.66|P-value:2.55E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.33|P-value:1.15E-4 ID:SGTC_1736|Compound:st036774|FD-Score:2.98|P-value:4.85E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.42|P-value:7.86E-5 ID:SGTC_1752|Compound:st044819|FD-Score:3.15|P-value:2.48E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.93|P-value:6.59E-6 ID:SGTC_1906|Compound:st060206|FD-Score:3.22|P-value:1.82E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.17|P-value:2.29E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.27|P-value:1.46E-4 ID:SGTC_1998|Compound:st075797|FD-Score:-3.35|P-value:8.27E-5 ID:SGTC_2077|Compound:5212015|FD-Score:-2.77|P-value:9.07E-4 ID:SGTC_2122|Compound:5258151|FD-Score:2.90|P-value:6.75E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.10|P-value:3.09E-4 ID:SGTC_2138|Compound:5575593|FD-Score:3.31|P-value:1.26E-4 ID:SGTC_2145|Compound:5634607|FD-Score:3.10|P-value:3.07E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.05|P-value:3.72E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-3.50|P-value:4.27E-5 ID:SGTC_2298|Compound:7976326|FD-Score:-3.66|P-value:2.03E-5 ID:SGTC_2308|Compound:7584454|FD-Score:2.91|P-value:6.38E-4 ID:SGTC_2352|Compound:9027995|FD-Score:2.83|P-value:8.71E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.53|P-value:4.77E-5 ID:SGTC_2424|Compound:5537928|FD-Score:5.50|P-value:5.22E-10 ID:SGTC_2427|Compound:5545055|FD-Score:2.81|P-value:9.38E-4 ID:SGTC_2429|Compound:5902844|FD-Score:-3.23|P-value:1.45E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.41|P-value:8.16E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:2.82|P-value:9.11E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.42|P-value:7.70E-5 ID:SGTC_2705|Compound:st078069|FD-Score:3.09|P-value:3.22E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.88|P-value:3.13E-8 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.93|P-value:2.34E-8 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:2.80|P-value:9.74E-4 ID:SGTC_2835|Compound:9006588|FD-Score:4.01|P-value:4.47E-6 ID:SGTC_2840|Compound:9008771|FD-Score:2.98|P-value:5.01E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.15|P-value:2.46E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-3.73|P-value:1.45E-5 ID:SGTC_3004|Compound:9076122|FD-Score:9.22|P-value:5.92E-25 ID:SGTC_3012|Compound:9080433|FD-Score:6.07|P-value:8.21E-12 ID:SGTC_3102|Compound:9121669|FD-Score:-2.86|P-value:6.64E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:-2.77|P-value:9.17E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.11|P-value:2.41E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.55|P-value:4.29E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-2.76|P-value:9.64E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:3.23|P-value:1.79E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:-3.02|P-value:3.49E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:3.86|P-value:9.37E-6 ID:SGTC_472|Compound:calcifediol|FD-Score:3.11|P-value:2.92E-4 ID:SGTC_489|Compound:paxilline|FD-Score:2.90|P-value:6.69E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:2.92|P-value:6.14E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.31|P-value:1.28E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.04|P-value:3.95E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:-3.12|P-value:2.24E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:-2.79|P-value:8.66E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:-2.88|P-value:6.10E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.05|P-value:3.68E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:2.93|P-value:5.89E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:2.94|P-value:5.75E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.06|P-value:3.53E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.42|P-value:7.82E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.73|P-value:1.82E-5 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.33|P-value:8.01E-7 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.66|P-value:2.55E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.33|P-value:1.15E-4 ID:SGTC_1736|Compound:st036774|FD-Score:2.98|P-value:4.85E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.42|P-value:7.86E-5 ID:SGTC_1752|Compound:st044819|FD-Score:3.15|P-value:2.48E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.93|P-value:6.59E-6 ID:SGTC_1906|Compound:st060206|FD-Score:3.22|P-value:1.82E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.17|P-value:2.29E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.27|P-value:1.46E-4 ID:SGTC_1998|Compound:st075797|FD-Score:-3.35|P-value:8.27E-5 ID:SGTC_2077|Compound:5212015|FD-Score:-2.77|P-value:9.07E-4 ID:SGTC_2122|Compound:5258151|FD-Score:2.90|P-value:6.75E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.10|P-value:3.09E-4 ID:SGTC_2138|Compound:5575593|FD-Score:3.31|P-value:1.26E-4 ID:SGTC_2145|Compound:5634607|FD-Score:3.10|P-value:3.07E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.05|P-value:3.72E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-3.50|P-value:4.27E-5 ID:SGTC_2298|Compound:7976326|FD-Score:-3.66|P-value:2.03E-5 ID:SGTC_2308|Compound:7584454|FD-Score:2.91|P-value:6.38E-4 ID:SGTC_2352|Compound:9027995|FD-Score:2.83|P-value:8.71E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.53|P-value:4.77E-5 ID:SGTC_2424|Compound:5537928|FD-Score:5.50|P-value:5.22E-10 ID:SGTC_2427|Compound:5545055|FD-Score:2.81|P-value:9.38E-4 ID:SGTC_2429|Compound:5902844|FD-Score:-3.23|P-value:1.45E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.41|P-value:8.16E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:2.82|P-value:9.11E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.42|P-value:7.70E-5 ID:SGTC_2705|Compound:st078069|FD-Score:3.09|P-value:3.22E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.88|P-value:3.13E-8 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.93|P-value:2.34E-8 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:2.80|P-value:9.74E-4 ID:SGTC_2835|Compound:9006588|FD-Score:4.01|P-value:4.47E-6 ID:SGTC_2840|Compound:9008771|FD-Score:2.98|P-value:5.01E-4 ID:SGTC_2960|Compound:9079389|FD-Score:3.15|P-value:2.46E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-3.73|P-value:1.45E-5 ID:SGTC_3004|Compound:9076122|FD-Score:9.22|P-value:5.92E-25 ID:SGTC_3012|Compound:9080433|FD-Score:6.07|P-value:8.21E-12 ID:SGTC_3102|Compound:9121669|FD-Score:-2.86|P-value:6.64E-4

Top fitness defect scores for YLR429W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3004 9076122 9.22 71.4 µM 5.92E-25 2 1.48E-20
2 SGTC_3012 9080433 6.07 71.4 µM 8.21E-12 1 6.52E-10
3 SGTC_2424 5537928 5.50 59.2 µM 5.22E-10 9 1.90E-8
4 SGTC_2758 dehydroepiandrosterone 4.93 69.3 µM 2.34E-8 23 4.20E-7
5 SGTC_2755 lomerizine 4.88 42.7 µM 3.13E-8 13 5.32E-7
6 SGTC_1454 4239-0054 4.33 42.6 µM 8.01E-7 23 7.48E-6
7 SGTC_2835 9006588 4.01 71.4 µM 4.47E-6 37 3.05E-5
8 SGTC_1900 st060200 3.93 72.8 µM 6.59E-6 23 4.18E-5
9 SGTC_432 NS 1619 3.86 61.3 µM 9.37E-6 30 5.58E-5
10 SGTC_1402 3909-7673 3.73 35.9 µM 1.82E-5 25 9.59E-5
11 SGTC_1506 4226-2149 3.66 212.0 µM 2.55E-5 36 1.27E-4
12 SGTC_58 0957-0393 3.55 9.0 µM 4.29E-5 cell wall 425 1.94E-4
13 SGTC_2396 5342950 3.53 42.8 µM 4.77E-5 RSC complex & mRNA processing 65 2.11E-4
14 SGTC_2546 rhodinyl acetate 3.42 100.0 µM 7.70E-5 24 3.13E-4
15 SGTC_1385 3091-4834 3.42 14.1 µM 7.82E-5 RPP1 & pyrimidine depletion 33 3.17E-4
16 SGTC_1746 st038117 3.42 42.0 µM 7.86E-5 53 3.18E-4
17 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 3.41 92.6 µM 8.16E-5 44 3.28E-4
18 SGTC_1584 6-fluoro-dl-tryptophan 3.33 90.0 µM 1.15E-4 mitochondrial processes 38 4.34E-4
19 SGTC_2138 5575593 3.31 77.7 µM 1.26E-4 26 4.69E-4
20 SGTC_584 0986-0246 3.31 15.4 µM 1.28E-4 heme requiring 29 4.74E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 1.02E-9 YIL106W MOB1 het Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
0.099 8.21E-9 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.094 4.39E-8 YML057W CMP2 hom Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.094 4.56E-8 YHR061C GIC1 hom Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bud neck to nucleus upon DNA replication stress
0.094 4.93E-8 YDL189W RBS1 hom Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
0.094 5.17E-8 YCL040W GLK1 hom Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication
0.093 7.21E-8 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.092 8.27E-8 YGL015C_p YGL015C_p hom Putative protein of unknown function; null mutants accumulate cargo in the Golgi
0.092 8.61E-8 YCL033C MXR2 hom Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan
0.091 1.16E-7 YPL046C ELC1 hom Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair
0.084 1.06E-6 YBR221W-A_p YBR221W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.084 1.16E-6 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.084 1.17E-6 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.083 1.28E-6 YLR232W_d YLR232W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5
0.082 1.71E-6 YBR244W GPX2 hom Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress