HIPHOP chemogenomics database

YLR448W / RPL6B

Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR448W / RPL6B

Click on Significant Values for Screen Details

Top fitness defect scores for YLR448W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2422	chlorphenesin carbamate	6.86	384.2 µM	4.36E-11		2	3.57E-12
2	SGTC_2335	9018011	6.24	154.2 µM	1.79E-9		4	2.25E-10
3	SGTC_2877	9040724	5.90	71.4 µM	1.16E-8		1	1.81E-9
4	SGTC_3089	9117425	5.44	49.5 µM	1.29E-7		3	2.63E-8
5	SGTC_246	cycloheximide	5.06	667.0 µM	8.13E-7		7	2.05E-7
6	SGTC_1980	st071811	5.03	45.7 µM	9.38E-7	RPP1 & pyrimidine depletion	5	2.41E-7
7	SGTC_2489	cantharidin	4.89	73.4 µM	1.83E-6	cell wall signaling	22	5.06E-7
8	SGTC_2405	ticlatone	4.81	3.5 µM	2.59E-6		41	7.46E-7
9	SGTC_1536	cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid	4.63	61.9 µM	5.70E-6		4	1.79E-6
10	SGTC_849	0386-0493	4.48	241.0 µM	1.08E-5		8	3.67E-6
11	SGTC_303	1348-1668	4.43	34.2 µM	1.33E-5		5	4.62E-6
12	SGTC_2806	7952793	4.42	58.4 µM	1.44E-5		11	5.01E-6
13	SGTC_529	4076-0302	4.32	30.3 µM	2.12E-5	mitochondrial processes	13	7.72E-6
14	SGTC_3347	9188721	4.26	44.7 µM	2.69E-5		17	1.01E-5
15	SGTC_1153	4055-0057	4.16	267.0 µM	4.07E-5		21	1.60E-5
16	SGTC_1272	0839-0021	4.16	27.0 µM	4.09E-5		12	1.60E-5
17	SGTC_2123	5259487	4.09	200.0 µM	5.39E-5		17	2.18E-5
18	SGTC_2967	9089538	3.96	49.9 µM	8.80E-5		31	3.76E-5
19	SGTC_2688	kanamycin b	3.88	96.7 µM	1.17E-4	calcium & mitochondrial duress	381	5.14E-5
20	SGTC_1035	k081-0041	3.83	55.2 µM	1.45E-4	Golgi	26	6.53E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.163	2.26E-21	YDR101C	ARX1	hom	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.125	4.23E-13	YML094W	GIM5	hom	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.124	7.17E-13	YOR282W_d	YOR282W_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.119	3.81E-12	YCR047C	BUD23	hom	Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern
0.115	2.74E-11	YBR191W	RPL21A	hom	Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.113	4.98E-11	YBR189W	RPS9B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.112	6.92E-11	YIL110W	HPM1	hom	AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance
0.111	1.35E-10	YGL188C-A_p	YGL188C-A_p	hom	Putative protein of unknown function
0.110	1.78E-10	YML073C	RPL6A	hom	Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.101	4.42E-9	YFL033C	RIM15	hom	Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.101	5.08E-9	YGR160W_d	YGR160W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.100	5.95E-9	YDR417C_d	YDR417C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.100	6.88E-9	YGR085C	RPL11B	hom	Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication
0.098	1.21E-8	YHR205W	SCH9	hom	AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.097	2.05E-8	YJL177W	RPL17B	hom	Ribosomal 60S subunit protein L17B; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication