Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
Profile for YLR455W / YLR455W

Click on Significant Values for Screen Details

Top fitness defect scores for YLR455W deletion by condition

RankScreen IDConditionFD ScoreConc
1 SGTC_1149 3909-7961 8.55 23.3 µM 4.21E-16 1 5.93E-18
2 SGTC_2561 acetosyringone 7.73 100.0 µM 1.80E-13 2 5.47E-15
3 SGTC_1203 3992-3522 7.62 103.0 µM 3.74E-13 2 1.25E-14
4 SGTC_3029 9088683 6.24 49.5 µM 2.17E-9 4 2.17E-10
5 SGTC_1930 st074634 6.06 34.3 µM 5.88E-9 RNA pol III & RNase P/MRP 10 6.64E-10
6 SGTC_2484 5809818 5.94 12.0 µM 1.19E-8 3 1.46E-9
7 SGTC_74 000s-0487 5.71 160.3 µM 3.97E-8 8 5.70E-9
8 SGTC_2831 7999036 5.38 19.5 µM 2.09E-7 13 3.70E-8
9 SGTC_1474 0330-0125 5.20 5.3 µM 5.02E-7 9 9.91E-8
10 SGTC_622 1348-1566 5.08 26.3 µM 8.84E-7 6 1.87E-7
11 SGTC_488 nitrendipine 5.01 139.0 µM 1.25E-6 28 2.77E-7
12 SGTC_2964 9083345 4.92 53.4 µM 1.89E-6 9 4.41E-7
13 SGTC_3175 9106517 4.83 49.5 µM 2.75E-6 iron homeostasis 8 6.70E-7
14 SGTC_572 0960-0087 4.82 17.7 µM 2.86E-6 9 7.02E-7
15 SGTC_1159 4092-0538 4.76 61.2 µM 3.89E-6 14 9.92E-7
16 SGTC_3024 9090631 4.68 49.5 µM 5.43E-6 5 1.44E-6
17 SGTC_1136 pergolide 4.55 1.1 µM 9.38E-6 24 2.66E-6
18 SGTC_389 tpck 4.33 16.7 µM 2.39E-5 22 7.62E-6
19 SGTC_1116 jasmonic acid 4.10 1.6 µM 5.84E-5 21 2.08E-5
20 SGTC_2307 7538926 4.09 6.3 µM 5.96E-5 38 2.13E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.34E-12 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.101 4.18E-9 YOR090C PTC5 hom Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p
0.096 2.33E-8 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.092 9.15E-8 YMR221C_p YMR221C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy
0.089 2.50E-7 YJR025C BNA1 hom 3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
0.086 6.60E-7 YER046W SPO73 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
0.085 9.54E-7 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
0.085 9.40E-7 YER051W JHD1 hom JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
0.085 9.40E-7 YBR241C_p YBR241C_p hom Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
0.082 2.13E-6 YGR187C HGH1 hom Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress
0.082 2.14E-6 YDL145C COP1 het Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
0.080 3.22E-6 YMR156C TPP1 hom DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3′-phosphatase
0.078 6.47E-6 YBL106C SRO77 hom Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication
0.077 7.96E-6 YIL152W_p YIL152W_p hom Putative protein of unknown function
0.077 8.28E-6 YMR140W SIP5 hom Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress