YLR456W_p

Putative pyridoxal 5'-phosphate synthase; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR456W / YLR456W

Click on Significant Values for Screen Details ID:SGTC_197|Compound:4544-0043|FD-Score:-3.11|P-value:3.46E-4 ID:SGTC_223|Compound:busulfan|FD-Score:-3.13|P-value:3.31E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-3.52|P-value:6.24E-5 ID:SGTC_234|Compound:nsc-17383|FD-Score:2.92|P-value:6.11E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.23|P-value:1.72E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:2.92|P-value:6.08E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.37|P-value:1.21E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.13|P-value:2.62E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.78|P-value:1.41E-5 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:4.40|P-value:5.65E-7 ID:SGTC_551|Compound:k048-0028|FD-Score:3.06|P-value:3.41E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:2.89|P-value:6.80E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.12|P-value:2.72E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:2.80|P-value:9.56E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.10|P-value:2.96E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.18|P-value:2.16E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.09|P-value:3.05E-4 ID:SGTC_1115|Compound:galangin|FD-Score:2.83|P-value:8.59E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:2.83|P-value:8.61E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:-3.26|P-value:1.93E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.26|P-value:1.92E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.40|P-value:1.05E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:2.96|P-value:5.18E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:2.79|P-value:9.92E-4 ID:SGTC_1644|Compound:st010134|FD-Score:2.98|P-value:4.76E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.41|P-value:7.81E-5 ID:SGTC_1912|Compound:st060209|FD-Score:-3.62|P-value:3.90E-5 ID:SGTC_1934|Compound:st074720|FD-Score:3.34|P-value:1.07E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-2.90|P-value:7.98E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.38|P-value:8.89E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.04|P-value:3.82E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.02|P-value:5.11E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.66|P-value:2.55E-5 ID:SGTC_2101|Compound:5377231|FD-Score:3.34|P-value:1.10E-4 ID:SGTC_2122|Compound:5258151|FD-Score:2.95|P-value:5.36E-4 ID:SGTC_2203|Compound:7227154|FD-Score:-2.95|P-value:6.71E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.07|P-value:3.28E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.33|P-value:8.33E-7 ID:SGTC_2304|Compound:7443016|FD-Score:-3.10|P-value:3.60E-4 ID:SGTC_2306|Compound:7482397|FD-Score:2.79|P-value:9.84E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.08|P-value:3.16E-4 ID:SGTC_2374|Compound:9071832|FD-Score:3.08|P-value:3.15E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.05|P-value:3.55E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.05|P-value:4.52E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.21|P-value:1.92E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.49|P-value:5.61E-5 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.24|P-value:1.65E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.63|P-value:2.94E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:2.86|P-value:7.60E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.45|P-value:6.64E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.52|P-value:4.84E-5 ID:SGTC_2740|Compound:felodipine|FD-Score:2.99|P-value:4.61E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-2.89|P-value:8.15E-4 ID:SGTC_2804|Compound:7954240|FD-Score:2.86|P-value:7.67E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.08|P-value:3.27E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.01|P-value:4.31E-4 ID:SGTC_3147|Compound:9097027|FD-Score:-3.04|P-value:4.70E-4 ID:SGTC_3209|Compound:9113616|FD-Score:4.00|P-value:4.85E-6 ID:SGTC_3306|Compound:9127676|FD-Score:4.14|P-value:2.37E-6 ID:SGTC_3320|Compound:9137005|FD-Score:3.14|P-value:2.49E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-2.95|P-value:6.50E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.51|P-value:5.02E-5 ID:SGTC_197|Compound:4544-0043|FD-Score:-3.11|P-value:3.46E-4 ID:SGTC_223|Compound:busulfan|FD-Score:-3.13|P-value:3.31E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-3.52|P-value:6.24E-5 ID:SGTC_234|Compound:nsc-17383|FD-Score:2.92|P-value:6.11E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.23|P-value:1.72E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:2.92|P-value:6.08E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-3.37|P-value:1.21E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.13|P-value:2.62E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:3.78|P-value:1.41E-5 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:4.40|P-value:5.65E-7 ID:SGTC_551|Compound:k048-0028|FD-Score:3.06|P-value:3.41E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:2.89|P-value:6.80E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.12|P-value:2.72E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:2.80|P-value:9.56E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.10|P-value:2.96E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:3.18|P-value:2.16E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.09|P-value:3.05E-4 ID:SGTC_1115|Compound:galangin|FD-Score:2.83|P-value:8.59E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:2.83|P-value:8.61E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:-3.26|P-value:1.93E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.26|P-value:1.92E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.40|P-value:1.05E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:2.96|P-value:5.18E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:2.79|P-value:9.92E-4 ID:SGTC_1644|Compound:st010134|FD-Score:2.98|P-value:4.76E-4 ID:SGTC_1819|Compound:st053448|FD-Score:3.41|P-value:7.81E-5 ID:SGTC_1912|Compound:st060209|FD-Score:-3.62|P-value:3.90E-5 ID:SGTC_1934|Compound:st074720|FD-Score:3.34|P-value:1.07E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-2.90|P-value:7.98E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.38|P-value:8.89E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.04|P-value:3.82E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.02|P-value:5.11E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.66|P-value:2.55E-5 ID:SGTC_2101|Compound:5377231|FD-Score:3.34|P-value:1.10E-4 ID:SGTC_2122|Compound:5258151|FD-Score:2.95|P-value:5.36E-4 ID:SGTC_2203|Compound:7227154|FD-Score:-2.95|P-value:6.71E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.07|P-value:3.28E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.33|P-value:8.33E-7 ID:SGTC_2304|Compound:7443016|FD-Score:-3.10|P-value:3.60E-4 ID:SGTC_2306|Compound:7482397|FD-Score:2.79|P-value:9.84E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.08|P-value:3.16E-4 ID:SGTC_2374|Compound:9071832|FD-Score:3.08|P-value:3.15E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.05|P-value:3.55E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.05|P-value:4.52E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.21|P-value:1.92E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.49|P-value:5.61E-5 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.24|P-value:1.65E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.63|P-value:2.94E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:2.86|P-value:7.60E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:3.45|P-value:6.64E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.52|P-value:4.84E-5 ID:SGTC_2740|Compound:felodipine|FD-Score:2.99|P-value:4.61E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-2.89|P-value:8.15E-4 ID:SGTC_2804|Compound:7954240|FD-Score:2.86|P-value:7.67E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.08|P-value:3.27E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.01|P-value:4.31E-4 ID:SGTC_3147|Compound:9097027|FD-Score:-3.04|P-value:4.70E-4 ID:SGTC_3209|Compound:9113616|FD-Score:4.00|P-value:4.85E-6 ID:SGTC_3306|Compound:9127676|FD-Score:4.14|P-value:2.37E-6 ID:SGTC_3320|Compound:9137005|FD-Score:3.14|P-value:2.49E-4 ID:SGTC_3324|Compound:9138759|FD-Score:-2.95|P-value:6.50E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.51|P-value:5.02E-5

Top fitness defect scores for YLR456W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_477 mead ethanolamide 4.40 10.0 µM 5.65E-7 3 5.33E-6
2 SGTC_2289 7946404 4.33 165.1 µM 8.33E-7 79 7.36E-6
3 SGTC_3306 9127676 4.14 59.8 µM 2.37E-6 15 1.76E-5
4 SGTC_3209 9113616 4.00 49.5 µM 4.85E-6 24 3.18E-5
5 SGTC_428 3448-4153 3.78 16.5 µM 1.41E-5 TSC3-RPN4 37 7.73E-5
6 SGTC_2017 5132927 3.66 60.6 µM 2.55E-5 37 1.26E-4
7 SGTC_2567 aureobasidin a 3.63 60.0 nM 2.94E-5 108 1.42E-4
8 SGTC_2689 tacrolimus 3.52 100.0 µM 4.84E-5 66 2.15E-4
9 SGTC_3328 9140624 3.51 29.0 µM 5.02E-5 29 2.21E-4
10 SGTC_2518 prenyletin 3.49 46.3 µM 5.61E-5 18 2.43E-4
11 SGTC_2610 ononetin 3.45 44.2 µM 6.64E-5 64 2.79E-4
12 SGTC_1819 st053448 3.41 58.6 µM 7.81E-5 amide catabolism 36 3.20E-4
13 SGTC_1994 st072947 3.38 40.9 µM 8.89E-5 33 3.56E-4
14 SGTC_1934 st074720 3.34 32.6 µM 1.07E-4 86 4.15E-4
15 SGTC_2101 5377231 3.34 179.2 µM 1.10E-4 17 4.24E-4
16 SGTC_2524 avocatin b 3.24 10.6 µM 1.65E-4 45 5.95E-4
17 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 3.23 4.6 µM 1.72E-4 heat shock/prefoldin 68 6.15E-4
18 SGTC_2455 5377712 3.21 9.8 µM 1.92E-4 47 6.75E-4
19 SGTC_716 1683-5115 3.18 658.0 µM 2.16E-4 50 7.47E-4
20 SGTC_3320 9137005 3.14 35.1 µM 2.49E-4 endomembrane recycling 46 8.40E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.196 2.91E-30 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.165 8.11E-22 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.164 1.69E-21 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.158 4.58E-20 YLR400W_d YLR400W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.154 3.25E-19 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.147 1.19E-17 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.138 1.16E-15 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.137 1.58E-15 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.137 2.61E-15 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.131 2.24E-14 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.126 2.28E-13 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.124 5.05E-13 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.124 5.88E-13 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.123 1.05E-12 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.122 1.16E-12 YOR267C HRK1 hom Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress