YLR461W / PAU4

Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR461W / PAU4

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.84|P-value:7.99E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:3.64|P-value:1.70E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:-3.66|P-value:1.52E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.23|P-value:7.60E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.95|P-value:5.23E-5 ID:SGTC_306|Compound:1672-3436|FD-Score:3.49|P-value:3.05E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.15|P-value:9.75E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:4.47|P-value:5.62E-6 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.73|P-value:1.19E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.28|P-value:6.43E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:-3.26|P-value:6.49E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.16|P-value:9.34E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.16|P-value:9.37E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.39|P-value:4.24E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:4.42|P-value:6.92E-6 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.94|P-value:5.10E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:3.28|P-value:6.37E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-5.25|P-value:1.12E-7 ID:SGTC_789|Compound:1309-1135|FD-Score:-4.86|P-value:8.37E-7 ID:SGTC_801|Compound:0866-0028|FD-Score:3.67|P-value:1.57E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.33|P-value:5.35E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.18|P-value:8.74E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:5.46|P-value:3.87E-8 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.34|P-value:9.78E-6 ID:SGTC_1205|Compound:4161-2785|FD-Score:-4.12|P-value:2.45E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.37|P-value:8.65E-6 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.47|P-value:3.19E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.75|P-value:1.13E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.94|P-value:5.34E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.93|P-value:5.57E-5 ID:SGTC_1673|Compound:st016611|FD-Score:3.22|P-value:7.70E-4 ID:SGTC_1689|Compound:st020265|FD-Score:3.36|P-value:4.74E-4 ID:SGTC_1751|Compound:st044839|FD-Score:3.42|P-value:3.93E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.36|P-value:4.74E-4 ID:SGTC_1790|Compound:st045711|FD-Score:-3.54|P-value:2.41E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.61|P-value:2.93E-6 ID:SGTC_1958|Compound:st076513|FD-Score:3.84|P-value:7.98E-5 ID:SGTC_2029|Compound:5175081|FD-Score:3.15|P-value:9.89E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.35|P-value:4.90E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.18|P-value:8.98E-4 ID:SGTC_2180|Compound:6301957|FD-Score:4.05|P-value:3.39E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.40|P-value:7.42E-6 ID:SGTC_2285|Compound:7945142|FD-Score:4.74|P-value:1.56E-6 ID:SGTC_2346|Compound:9031566|FD-Score:3.99|P-value:4.40E-5 ID:SGTC_2455|Compound:5377712|FD-Score:3.51|P-value:2.77E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.69|P-value:1.42E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:3.57|P-value:2.21E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.37|P-value:4.61E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.16|P-value:2.17E-5 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.64|P-value:1.75E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.82|P-value:8.53E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.08|P-value:3.07E-5 ID:SGTC_2698|Compound:st077697|FD-Score:3.58|P-value:2.19E-4 ID:SGTC_2717|Compound:st081029|FD-Score:3.15|P-value:9.74E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.89|P-value:6.51E-5 ID:SGTC_2967|Compound:9089538|FD-Score:3.31|P-value:5.68E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.67|P-value:1.55E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.74|P-value:1.16E-4 ID:SGTC_3235|Compound:9132602|FD-Score:-3.28|P-value:6.09E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.84|P-value:7.99E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:3.64|P-value:1.70E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:-3.66|P-value:1.52E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:3.23|P-value:7.60E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.95|P-value:5.23E-5 ID:SGTC_306|Compound:1672-3436|FD-Score:3.49|P-value:3.05E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.15|P-value:9.75E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:4.47|P-value:5.62E-6 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.73|P-value:1.19E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.28|P-value:6.43E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:-3.26|P-value:6.49E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.16|P-value:9.34E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.16|P-value:9.37E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.39|P-value:4.24E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:4.42|P-value:6.92E-6 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.94|P-value:5.10E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:3.28|P-value:6.37E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-5.25|P-value:1.12E-7 ID:SGTC_789|Compound:1309-1135|FD-Score:-4.86|P-value:8.37E-7 ID:SGTC_801|Compound:0866-0028|FD-Score:3.67|P-value:1.57E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.33|P-value:5.35E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.18|P-value:8.74E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:5.46|P-value:3.87E-8 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.34|P-value:9.78E-6 ID:SGTC_1205|Compound:4161-2785|FD-Score:-4.12|P-value:2.45E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.37|P-value:8.65E-6 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.47|P-value:3.19E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.75|P-value:1.13E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.94|P-value:5.34E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.93|P-value:5.57E-5 ID:SGTC_1673|Compound:st016611|FD-Score:3.22|P-value:7.70E-4 ID:SGTC_1689|Compound:st020265|FD-Score:3.36|P-value:4.74E-4 ID:SGTC_1751|Compound:st044839|FD-Score:3.42|P-value:3.93E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.36|P-value:4.74E-4 ID:SGTC_1790|Compound:st045711|FD-Score:-3.54|P-value:2.41E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.61|P-value:2.93E-6 ID:SGTC_1958|Compound:st076513|FD-Score:3.84|P-value:7.98E-5 ID:SGTC_2029|Compound:5175081|FD-Score:3.15|P-value:9.89E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.35|P-value:4.90E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.18|P-value:8.98E-4 ID:SGTC_2180|Compound:6301957|FD-Score:4.05|P-value:3.39E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.40|P-value:7.42E-6 ID:SGTC_2285|Compound:7945142|FD-Score:4.74|P-value:1.56E-6 ID:SGTC_2346|Compound:9031566|FD-Score:3.99|P-value:4.40E-5 ID:SGTC_2455|Compound:5377712|FD-Score:3.51|P-value:2.77E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.69|P-value:1.42E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:3.57|P-value:2.21E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.37|P-value:4.61E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.16|P-value:2.17E-5 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.64|P-value:1.75E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.82|P-value:8.53E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.08|P-value:3.07E-5 ID:SGTC_2698|Compound:st077697|FD-Score:3.58|P-value:2.19E-4 ID:SGTC_2717|Compound:st081029|FD-Score:3.15|P-value:9.74E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.89|P-value:6.51E-5 ID:SGTC_2967|Compound:9089538|FD-Score:3.31|P-value:5.68E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.67|P-value:1.55E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.74|P-value:1.16E-4 ID:SGTC_3235|Compound:9132602|FD-Score:-3.28|P-value:6.09E-4

Top fitness defect scores for YLR461W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1194 1488-0194 5.46 225.0 µM 3.87E-8 10 2.35E-8
2 SGTC_2285 7945142 4.74 200.0 µM 1.56E-6 8 1.06E-6
3 SGTC_1911 st060208 4.61 74.3 µM 2.93E-6 20 2.04E-6
4 SGTC_314 1671-0008 4.47 2.7 µM 5.62E-6 35 3.98E-6
5 SGTC_774 k060-0086 4.42 136.0 µM 6.92E-6 12 4.94E-6
6 SGTC_2233 sulbentine 4.40 40.4 µM 7.42E-6 42 5.30E-6
7 SGTC_1374 2889-5571 4.37 141.0 µM 8.65E-6 RSC complex & mRNA processing 28 6.22E-6
8 SGTC_1195 1502-0147 4.34 41.1 µM 9.78E-6 13 7.05E-6
9 SGTC_2567 aureobasidin a 4.16 60.0 nM 2.17E-5 88 1.60E-5
10 SGTC_2687 chenodiol 4.08 100.0 µM 3.07E-5 21 2.29E-5
11 SGTC_2180 6301957 4.05 200.0 µM 3.39E-5 RSC complex & mRNA processing 6 2.54E-5
12 SGTC_2346 9031566 3.99 143.8 µM 4.40E-5 Golgi 15 3.33E-5
13 SGTC_304 1310-0298 3.95 97.0 µM 5.23E-5 cell wall 62 3.97E-5
14 SGTC_1538 2',3',6-trimethoxyflavanone 3.94 63.6 µM 5.34E-5 15 4.06E-5
15 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 3.93 67.5 µM 5.57E-5 42 4.24E-5
16 SGTC_2768 sulfasalazine 3.89 50.2 µM 6.51E-5 16 4.98E-5
17 SGTC_1958 st076513 3.84 41.9 µM 7.98E-5 60S ribosome export 32 6.15E-5
18 SGTC_58 0957-0393 3.84 9.0 µM 7.99E-5 cell wall 386 6.15E-5
19 SGTC_2636 apigenin dimethyl ether 3.82 100.0 µM 8.53E-5 53 6.58E-5
20 SGTC_1494 4358-1428 3.75 177.0 µM 1.13E-4 27 8.82E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 4.25E-13 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.116 1.68E-11 YBR244W GPX2 hom Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress
0.114 3.31E-11 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.113 4.51E-11 YDR453C TSA2 hom Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress
0.094 5.66E-8 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.091 1.16E-7 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.089 2.35E-7 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.088 3.22E-7 YBR300C_d YBR300C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene
0.087 4.80E-7 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.086 5.95E-7 YKL071W_p YKL071W_p hom Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.083 1.71E-6 YCR085W_d YCR085W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.082 1.81E-6 YOL036W_p YOL036W_p hom Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication
0.082 1.89E-6 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.081 2.59E-6 YBR211C AME1 het Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress
0.081 2.90E-6 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C