HIPHOP chemogenomics database

YML020W_p

Putative protein of unknown function

Zygosity: Homozygous strain

fixedexpanded
Profile for YML020W / YML020W

Click on Significant Values for Screen Details

Top fitness defect scores for YML020W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1904	st060225	5.71	78.0 µM	5.20E-9		5	5.78E-9
2	SGTC_260	nsc-65238	5.19	4.0 µM	9.73E-8	endomembrane recycling	5	1.06E-7
3	SGTC_349	k015-0014	5.12	24.0 µM	1.38E-7		7	1.51E-7
4	SGTC_290	2043-6722	4.41	48.1 µM	4.79E-6		4	5.12E-6
5	SGTC_2379	9035213	4.36	200.0 µM	6.04E-6		13	6.46E-6
6	SGTC_2317	5986382	4.34	200.0 µM	6.77E-6		8	7.23E-6
7	SGTC_310	1273-0058	4.29	1.1 µM	8.55E-6	mitochondrial stress	224	9.12E-6
8	SGTC_1371	2421-0008	4.14	32.7 µM	1.65E-5	mitochondrial processes	29	1.75E-5
9	SGTC_1502	4534-4282	4.13	27.7 µM	1.73E-5		9	1.84E-5
10	SGTC_318	1488-0629	4.09	67.2 µM	2.06E-5	copper-dependent oxidative stress	21	2.18E-5
11	SGTC_343	4130-2827	4.01	29.8 µM	2.83E-5		32	2.99E-5
12	SGTC_504	lovastatin	4.01	124.0 µM	2.92E-5		15	3.09E-5
13	SGTC_99	0109-0120	3.97	622.8 µM	3.43E-5		15	3.64E-5
14	SGTC_332	4112-0506	3.96	40.9 µM	3.56E-5		23	3.76E-5
15	SGTC_1430	4049-0248	3.94	69.1 µM	3.93E-5		20	4.16E-5
16	SGTC_1524	corynanthine	3.92	62.1 µM	4.17E-5		17	4.40E-5
17	SGTC_320	4092-0846	3.88	5.3 µM	4.87E-5	ergosterol depletion effects on membrane	49	5.14E-5
18	SGTC_1591	genipin	3.86	88.4 µM	5.40E-5	mitochondrial processes	15	5.70E-5
19	SGTC_1892	st058411	3.82	7.4 µM	6.39E-5		24	6.74E-5
20	SGTC_669	0108-0021	3.67	26.2 µM	1.15E-4	fatty acid desaturase (OLE1)	96	1.20E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.095	3.63E-8	YDL214C	PRR2	hom	Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance
0.094	5.60E-8	YDL201W	TRM8	hom	Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.081	2.41E-6	YNL154C	YCK2	hom	Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication
0.078	5.86E-6	YOR071C	NRT1	hom	High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
0.078	6.03E-6	YGR288W	MAL13	hom	MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C
0.078	6.74E-6	YLR244C	MAP1	hom	Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p
0.077	7.01E-6	YFL056C	AAD6	hom	Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.077	7.97E-6	YPL210C	SRP72	het	Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
0.076	9.43E-6	YOL090W	MSH2	hom	Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP
0.075	1.30E-5	YDR165W	TRM82	hom	Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.075	1.30E-5	YLL030C_d	RRT7_d	hom	Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.075	1.33E-5	YML074C	FPR3	hom	Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
0.075	1.43E-5	YDR294C	DPL1	hom	Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.073	2.03E-5	YGR101W	PCP1	hom	Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases
0.073	2.18E-5	YDL016C_d	YDL016C_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication