YML020W_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YML020W / YML020W

Click on Significant Values for Screen Details ID:SGTC_99|Compound:0109-0120|FD-Score:3.97|P-value:3.43E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:3.32|P-value:4.30E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.50|P-value:2.19E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:5.19|P-value:9.73E-8 ID:SGTC_271|Compound:rotenone|FD-Score:3.31|P-value:4.40E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:4.41|P-value:4.79E-6 ID:SGTC_308|Compound:4092-1169|FD-Score:3.19|P-value:6.72E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.29|P-value:8.55E-6 ID:SGTC_318|Compound:1488-0629|FD-Score:4.09|P-value:2.06E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:3.88|P-value:4.87E-5 ID:SGTC_332|Compound:4112-0506|FD-Score:3.96|P-value:3.56E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:3.15|P-value:7.81E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.01|P-value:2.83E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:5.12|P-value:1.38E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.10|P-value:9.68E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-3.27|P-value:5.30E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:4.01|P-value:2.92E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.67|P-value:1.15E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.57|P-value:1.72E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.40|P-value:3.19E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.26|P-value:5.26E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.41|P-value:3.13E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.16|P-value:7.49E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.14|P-value:1.65E-5 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.94|P-value:3.93E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:4.13|P-value:1.73E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.92|P-value:4.17E-5 ID:SGTC_1591|Compound:genipin|FD-Score:3.86|P-value:5.40E-5 ID:SGTC_1742|Compound:st038235|FD-Score:-4.51|P-value:3.13E-6 ID:SGTC_1801|Compound:st050089|FD-Score:3.27|P-value:5.14E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.29|P-value:4.77E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.82|P-value:6.39E-5 ID:SGTC_1904|Compound:st060225|FD-Score:5.71|P-value:5.20E-9 ID:SGTC_2128|Compound:5255449|FD-Score:-3.46|P-value:2.64E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.49|P-value:2.29E-4 ID:SGTC_2190|Compound:6049624|FD-Score:3.34|P-value:3.97E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.14|P-value:8.07E-4 ID:SGTC_2256|Compound:7954252|FD-Score:-3.40|P-value:3.28E-4 ID:SGTC_2317|Compound:5986382|FD-Score:4.34|P-value:6.77E-6 ID:SGTC_2379|Compound:9035213|FD-Score:4.36|P-value:6.04E-6 ID:SGTC_2446|Compound:5162541|FD-Score:3.55|P-value:1.84E-4 ID:SGTC_2448|Compound:5185112|FD-Score:3.34|P-value:4.08E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.29|P-value:4.78E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.30|P-value:4.68E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.54|P-value:1.90E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.41|P-value:3.12E-4 ID:SGTC_3102|Compound:9121669|FD-Score:3.29|P-value:4.87E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.19|P-value:7.03E-4 ID:SGTC_3335|Compound:9143315|FD-Score:3.12|P-value:8.71E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.97|P-value:3.43E-5 ID:SGTC_245|Compound:methotrexate|FD-Score:3.32|P-value:4.30E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.50|P-value:2.19E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:5.19|P-value:9.73E-8 ID:SGTC_271|Compound:rotenone|FD-Score:3.31|P-value:4.40E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:4.41|P-value:4.79E-6 ID:SGTC_308|Compound:4092-1169|FD-Score:3.19|P-value:6.72E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.29|P-value:8.55E-6 ID:SGTC_318|Compound:1488-0629|FD-Score:4.09|P-value:2.06E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:3.88|P-value:4.87E-5 ID:SGTC_332|Compound:4112-0506|FD-Score:3.96|P-value:3.56E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:3.15|P-value:7.81E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.01|P-value:2.83E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:5.12|P-value:1.38E-7 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.10|P-value:9.68E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-3.27|P-value:5.30E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:4.01|P-value:2.92E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.67|P-value:1.15E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.57|P-value:1.72E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.40|P-value:3.19E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.26|P-value:5.26E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.41|P-value:3.13E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.16|P-value:7.49E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.14|P-value:1.65E-5 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.94|P-value:3.93E-5 ID:SGTC_1502|Compound:4534-4282|FD-Score:4.13|P-value:1.73E-5 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.92|P-value:4.17E-5 ID:SGTC_1591|Compound:genipin|FD-Score:3.86|P-value:5.40E-5 ID:SGTC_1742|Compound:st038235|FD-Score:-4.51|P-value:3.13E-6 ID:SGTC_1801|Compound:st050089|FD-Score:3.27|P-value:5.14E-4 ID:SGTC_1861|Compound:st057647|FD-Score:3.29|P-value:4.77E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.82|P-value:6.39E-5 ID:SGTC_1904|Compound:st060225|FD-Score:5.71|P-value:5.20E-9 ID:SGTC_2128|Compound:5255449|FD-Score:-3.46|P-value:2.64E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.49|P-value:2.29E-4 ID:SGTC_2190|Compound:6049624|FD-Score:3.34|P-value:3.97E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.14|P-value:8.07E-4 ID:SGTC_2256|Compound:7954252|FD-Score:-3.40|P-value:3.28E-4 ID:SGTC_2317|Compound:5986382|FD-Score:4.34|P-value:6.77E-6 ID:SGTC_2379|Compound:9035213|FD-Score:4.36|P-value:6.04E-6 ID:SGTC_2446|Compound:5162541|FD-Score:3.55|P-value:1.84E-4 ID:SGTC_2448|Compound:5185112|FD-Score:3.34|P-value:4.08E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.29|P-value:4.78E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.30|P-value:4.68E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.54|P-value:1.90E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.41|P-value:3.12E-4 ID:SGTC_3102|Compound:9121669|FD-Score:3.29|P-value:4.87E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.19|P-value:7.03E-4 ID:SGTC_3335|Compound:9143315|FD-Score:3.12|P-value:8.71E-4

Top fitness defect scores for YML020W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1904 st060225 5.71 78.0 µM 5.20E-9 5 5.78E-9
2 SGTC_260 nsc-65238 5.19 4.0 µM 9.73E-8 endomembrane recycling 5 1.06E-7
3 SGTC_349 k015-0014 5.12 24.0 µM 1.38E-7 7 1.51E-7
4 SGTC_290 2043-6722 4.41 48.1 µM 4.79E-6 4 5.12E-6
5 SGTC_2379 9035213 4.36 200.0 µM 6.04E-6 13 6.46E-6
6 SGTC_2317 5986382 4.34 200.0 µM 6.77E-6 8 7.23E-6
7 SGTC_310 1273-0058 4.29 1.1 µM 8.55E-6 mitochondrial stress 224 9.12E-6
8 SGTC_1371 2421-0008 4.14 32.7 µM 1.65E-5 mitochondrial processes 29 1.75E-5
9 SGTC_1502 4534-4282 4.13 27.7 µM 1.73E-5 9 1.84E-5
10 SGTC_318 1488-0629 4.09 67.2 µM 2.06E-5 copper-dependent oxidative stress 21 2.18E-5
11 SGTC_343 4130-2827 4.01 29.8 µM 2.83E-5 32 2.99E-5
12 SGTC_504 lovastatin 4.01 124.0 µM 2.92E-5 15 3.09E-5
13 SGTC_99 0109-0120 3.97 622.8 µM 3.43E-5 15 3.64E-5
14 SGTC_332 4112-0506 3.96 40.9 µM 3.56E-5 23 3.76E-5
15 SGTC_1430 4049-0248 3.94 69.1 µM 3.93E-5 20 4.16E-5
16 SGTC_1524 corynanthine 3.92 62.1 µM 4.17E-5 17 4.40E-5
17 SGTC_320 4092-0846 3.88 5.3 µM 4.87E-5 ergosterol depletion effects on membrane 49 5.14E-5
18 SGTC_1591 genipin 3.86 88.4 µM 5.40E-5 mitochondrial processes 15 5.70E-5
19 SGTC_1892 st058411 3.82 7.4 µM 6.39E-5 24 6.74E-5
20 SGTC_669 0108-0021 3.67 26.2 µM 1.15E-4 fatty acid desaturase (OLE1) 96 1.20E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.095 3.63E-8 YDL214C PRR2 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance
0.094 5.60E-8 YDL201W TRM8 hom Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.081 2.41E-6 YNL154C YCK2 hom Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication
0.078 5.86E-6 YOR071C NRT1 hom High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
0.078 6.03E-6 YGR288W MAL13 hom MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C
0.078 6.74E-6 YLR244C MAP1 hom Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p
0.077 7.01E-6 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.077 7.97E-6 YPL210C SRP72 het Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
0.076 9.43E-6 YOL090W MSH2 hom Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP
0.075 1.30E-5 YDR165W TRM82 hom Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.075 1.30E-5 YLL030C_d RRT7_d hom Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.075 1.33E-5 YML074C FPR3 hom Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
0.075 1.43E-5 YDR294C DPL1 hom Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.073 2.03E-5 YGR101W PCP1 hom Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases
0.073 2.18E-5 YDL016C_d YDL016C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication