YML022W / APT1

Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YML022W / APT1

Click on Significant Values for Screen Details ID:SGTC_162|Compound:k030-0015|FD-Score:-3.29|P-value:1.36E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-5.83|P-value:3.76E-11 ID:SGTC_171|Compound:k064-0041|FD-Score:-4.67|P-value:9.75E-8 ID:SGTC_362|Compound:0310-0100|FD-Score:2.78|P-value:6.84E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:2.77|P-value:7.08E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:-3.11|P-value:2.94E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-2.80|P-value:9.92E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:2.95|P-value:3.38E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.59|P-value:3.42E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:6.57|P-value:3.57E-14 ID:SGTC_622|Compound:1348-1566|FD-Score:2.72|P-value:8.58E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.09|P-value:1.89E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.04|P-value:2.33E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:2.87|P-value:4.67E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-2.88|P-value:7.29E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.05|P-value:2.26E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:2.75|P-value:7.62E-4 ID:SGTC_1644|Compound:st010134|FD-Score:3.48|P-value:3.25E-5 ID:SGTC_1655|Compound:st012546|FD-Score:2.95|P-value:3.42E-4 ID:SGTC_1656|Compound:st012921|FD-Score:2.71|P-value:8.77E-4 ID:SGTC_1782|Compound:st039423|FD-Score:2.87|P-value:4.72E-4 ID:SGTC_1798|Compound:st045719|FD-Score:2.71|P-value:8.87E-4 ID:SGTC_1831|Compound:st055328|FD-Score:-2.84|P-value:8.43E-4 ID:SGTC_1843|Compound:st055809|FD-Score:-3.02|P-value:4.15E-4 ID:SGTC_1912|Compound:st060209|FD-Score:2.80|P-value:6.21E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.29|P-value:7.68E-5 ID:SGTC_1995|Compound:st072814|FD-Score:3.02|P-value:2.59E-4 ID:SGTC_2055|Compound:5235184|FD-Score:-4.08|P-value:2.88E-6 ID:SGTC_2058|Compound:5236698|FD-Score:-3.00|P-value:4.55E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.22|P-value:1.07E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-2.84|P-value:8.63E-4 ID:SGTC_2105|Compound:5350118|FD-Score:2.68|P-value:9.97E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.20|P-value:1.94E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.01|P-value:2.71E-4 ID:SGTC_2319|Compound:6033012|FD-Score:-2.98|P-value:5.02E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-2.95|P-value:5.54E-4 ID:SGTC_2476|Compound:5806916|FD-Score:2.85|P-value:5.21E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.49|P-value:3.12E-5 ID:SGTC_2487|Compound:5918373|FD-Score:3.16|P-value:1.38E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.22|P-value:1.84E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:2.87|P-value:4.72E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-3.31|P-value:1.26E-4 ID:SGTC_2551|Compound:apiole|FD-Score:-3.47|P-value:5.97E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-2.84|P-value:8.64E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.10|P-value:1.83E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-2.81|P-value:9.65E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:6.35|P-value:2.48E-13 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-5.29|P-value:1.76E-9 ID:SGTC_2693|Compound:st077581|FD-Score:-2.95|P-value:5.47E-4 ID:SGTC_2784|Compound:7567673|FD-Score:2.78|P-value:6.70E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-3.89|P-value:7.77E-6 ID:SGTC_2874|Compound:9043904|FD-Score:2.69|P-value:9.46E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.23|P-value:1.05E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-3.01|P-value:4.46E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-5.22|P-value:2.95E-9 ID:SGTC_3128|Compound:9127691|FD-Score:-4.47|P-value:3.32E-7 ID:SGTC_3240|Compound:9133527|FD-Score:2.96|P-value:3.32E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:-3.29|P-value:1.36E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-5.83|P-value:3.76E-11 ID:SGTC_171|Compound:k064-0041|FD-Score:-4.67|P-value:9.75E-8 ID:SGTC_362|Compound:0310-0100|FD-Score:2.78|P-value:6.84E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:2.77|P-value:7.08E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:-3.11|P-value:2.94E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-2.80|P-value:9.92E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:2.95|P-value:3.38E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:-3.59|P-value:3.42E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:6.57|P-value:3.57E-14 ID:SGTC_622|Compound:1348-1566|FD-Score:2.72|P-value:8.58E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.09|P-value:1.89E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:3.04|P-value:2.33E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:2.87|P-value:4.67E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-2.88|P-value:7.29E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.05|P-value:2.26E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:2.75|P-value:7.62E-4 ID:SGTC_1644|Compound:st010134|FD-Score:3.48|P-value:3.25E-5 ID:SGTC_1655|Compound:st012546|FD-Score:2.95|P-value:3.42E-4 ID:SGTC_1656|Compound:st012921|FD-Score:2.71|P-value:8.77E-4 ID:SGTC_1782|Compound:st039423|FD-Score:2.87|P-value:4.72E-4 ID:SGTC_1798|Compound:st045719|FD-Score:2.71|P-value:8.87E-4 ID:SGTC_1831|Compound:st055328|FD-Score:-2.84|P-value:8.43E-4 ID:SGTC_1843|Compound:st055809|FD-Score:-3.02|P-value:4.15E-4 ID:SGTC_1912|Compound:st060209|FD-Score:2.80|P-value:6.21E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.29|P-value:7.68E-5 ID:SGTC_1995|Compound:st072814|FD-Score:3.02|P-value:2.59E-4 ID:SGTC_2055|Compound:5235184|FD-Score:-4.08|P-value:2.88E-6 ID:SGTC_2058|Compound:5236698|FD-Score:-3.00|P-value:4.55E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.22|P-value:1.07E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-2.84|P-value:8.63E-4 ID:SGTC_2105|Compound:5350118|FD-Score:2.68|P-value:9.97E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.20|P-value:1.94E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.01|P-value:2.71E-4 ID:SGTC_2319|Compound:6033012|FD-Score:-2.98|P-value:5.02E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-2.95|P-value:5.54E-4 ID:SGTC_2476|Compound:5806916|FD-Score:2.85|P-value:5.21E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.49|P-value:3.12E-5 ID:SGTC_2487|Compound:5918373|FD-Score:3.16|P-value:1.38E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.22|P-value:1.84E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:2.87|P-value:4.72E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:-3.31|P-value:1.26E-4 ID:SGTC_2551|Compound:apiole|FD-Score:-3.47|P-value:5.97E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-2.84|P-value:8.64E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.10|P-value:1.83E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-2.81|P-value:9.65E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:6.35|P-value:2.48E-13 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-5.29|P-value:1.76E-9 ID:SGTC_2693|Compound:st077581|FD-Score:-2.95|P-value:5.47E-4 ID:SGTC_2784|Compound:7567673|FD-Score:2.78|P-value:6.70E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-3.89|P-value:7.77E-6 ID:SGTC_2874|Compound:9043904|FD-Score:2.69|P-value:9.46E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.23|P-value:1.05E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-3.01|P-value:4.46E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-5.22|P-value:2.95E-9 ID:SGTC_3128|Compound:9127691|FD-Score:-4.47|P-value:3.32E-7 ID:SGTC_3240|Compound:9133527|FD-Score:2.96|P-value:3.32E-4

Top fitness defect scores for YML022W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_577 r071-0003 6.57 38.6 µM 3.57E-14 fatty acid desaturase (OLE1) 11 2.44E-11
2 SGTC_2686 alizarin 6.35 95.4 µM 2.48E-13 RPP1 & pyrimidine depletion 3 1.11E-10
3 SGTC_2477 5967686 3.49 25.2 µM 3.12E-5 41 2.43E-4
4 SGTC_1644 st010134 3.48 20.9 µM 3.25E-5 mitochondrial processes 21 2.51E-4
5 SGTC_1993 st073995 3.29 70.8 µM 7.68E-5 38 4.92E-4
6 SGTC_2882 9058044 3.23 58.4 µM 1.05E-4 34 6.27E-4
7 SGTC_2061 5245884 3.22 81.0 µM 1.07E-4 tubulin folding & SWR complex 51 6.39E-4
8 SGTC_2487 5918373 3.16 44.0 µM 1.38E-4 45 7.79E-4
9 SGTC_2621 lithochol-11-enic acid 3.10 100.0 µM 1.83E-4 72 9.73E-4
10 SGTC_1039 k821-0043 3.09 94.0 µM 1.89E-4 Golgi 61 9.97E-4
11 SGTC_1560 lithocholic acid 3.05 53.1 µM 2.26E-4 17 0.00115
12 SGTC_1092 toremifene 3.04 6.3 µM 2.33E-4 66 0.00117
13 SGTC_1995 st072814 3.02 61.1 µM 2.59E-4 46 0.00128
14 SGTC_2314 7727897 3.01 200.0 µM 2.71E-4 65 0.00133
15 SGTC_3240 9133527 2.96 49.5 µM 3.32E-4 46 0.00155
16 SGTC_543 3844-1095 2.95 191.0 µM 3.38E-4 ERG2 100 0.00157
17 SGTC_1655 st012546 2.95 55.1 µM 3.42E-4 70 0.00159
18 SGTC_1332 1480-0653 2.87 17.5 µM 4.67E-4 TSC3-RPN4 61 0.00203
19 SGTC_2540 epiandrosterone 2.87 100.0 µM 4.72E-4 148 0.00205
20 SGTC_1782 st039423 2.87 80.6 µM 4.72E-4 85 0.00205

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 7.60E-12 YLR059C REX2 hom 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease
0.097 1.96E-8 YLR043C TRX1 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.095 3.28E-8 YOR181W LAS17 het Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
0.094 5.10E-8 YOR359W VTS1 hom Flap-structured DNA-binding and RNA-binding protein; stimulates deadenylation-dependent mRNA degradation mediated by the CCR4-NOT deadenylase complex; member of the Smaug (Smg) family of post-transcriptional regulators which bind RNA through a conserved sterile alpha motif (SAM) domain that interacts with Smg recognition element (SREs) containing transcripts; stimulates Dna2p endonuclease activity
0.091 1.40E-7 YHR029C YHI9 hom Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production
0.086 5.42E-7 YDR201W SPC19 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
0.085 8.99E-7 YKL022C CDC16 het Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation
0.083 1.56E-6 YPR176C BET2 het Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.077 8.74E-6 YMR297W PRC1 hom Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family
0.074 2.02E-5 YMR013W-A_d YMR013W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73
0.072 3.01E-5 YPL222W_p FMP40_p hom Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.072 3.11E-5 YDL221W_d YDL221W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13
0.072 3.23E-5 YML048W GSF2 hom ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression
0.071 3.79E-5 YCL049C_p YCL049C_p hom Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene
0.071 4.24E-5 YFR035C_p YFR035C_p hom Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein