YML024W / RPS17A

Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YML024W / RPS17A

Click on Significant Values for Screen Details ID:SGTC_88|Compound:0180-0332|FD-Score:3.38|P-value:2.89E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.60|P-value:1.56E-6 ID:SGTC_195|Compound:4234-0266|FD-Score:4.18|P-value:1.10E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:4.19|P-value:1.06E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:-3.48|P-value:2.82E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.51|P-value:1.81E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.81|P-value:5.40E-5 ID:SGTC_897|Compound:1000-0139|FD-Score:3.96|P-value:2.88E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:3.77|P-value:6.34E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.04|P-value:9.69E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:-3.63|P-value:1.56E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.41|P-value:2.66E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:4.95|P-value:2.62E-7 ID:SGTC_1123|Compound:mangostin|FD-Score:3.12|P-value:7.33E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-4.92|P-value:4.87E-7 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.29|P-value:4.13E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.49|P-value:2.64E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.77|P-value:6.30E-5 ID:SGTC_1558|Compound:st069300|FD-Score:3.32|P-value:3.61E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:4.29|P-value:6.71E-6 ID:SGTC_1729|Compound:st035615|FD-Score:3.68|P-value:9.23E-5 ID:SGTC_1737|Compound:st035557|FD-Score:4.23|P-value:9.03E-6 ID:SGTC_1776|Compound:st049249|FD-Score:-3.43|P-value:3.35E-4 ID:SGTC_1781|Compound:st038725|FD-Score:5.34|P-value:3.25E-8 ID:SGTC_1793|Compound:st048256|FD-Score:-4.04|P-value:3.03E-5 ID:SGTC_1795|Compound:st049545|FD-Score:-4.87|P-value:6.14E-7 ID:SGTC_1796|Compound:st049173|FD-Score:-3.82|P-value:7.26E-5 ID:SGTC_1839|Compound:st053978|FD-Score:3.49|P-value:1.95E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.11|P-value:7.78E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.26|P-value:4.46E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.10|P-value:7.99E-4 ID:SGTC_2127|Compound:5253358|FD-Score:5.68|P-value:4.38E-9 ID:SGTC_2132|Compound:5317594|FD-Score:6.78|P-value:3.55E-12 ID:SGTC_2140|Compound:5586273|FD-Score:3.26|P-value:4.56E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.13|P-value:7.19E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-3.72|P-value:1.10E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.51|P-value:1.82E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.19|P-value:5.87E-4 ID:SGTC_2446|Compound:5162541|FD-Score:3.11|P-value:7.71E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.69|P-value:8.96E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.30|P-value:5.26E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.24|P-value:6.69E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.17|P-value:8.28E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.07|P-value:8.92E-4 ID:SGTC_2717|Compound:st081029|FD-Score:-3.23|P-value:6.74E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-3.34|P-value:4.60E-4 ID:SGTC_3111|Compound:9122088|FD-Score:-4.09|P-value:2.40E-5 ID:SGTC_3148|Compound:9097893|FD-Score:3.46|P-value:2.14E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.94|P-value:3.21E-5 ID:SGTC_3212|Compound:9128307|FD-Score:3.32|P-value:3.60E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.76|P-value:9.55E-5 ID:SGTC_3314|Compound:9135860|FD-Score:-3.46|P-value:2.99E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:3.38|P-value:2.89E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.60|P-value:1.56E-6 ID:SGTC_195|Compound:4234-0266|FD-Score:4.18|P-value:1.10E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:4.19|P-value:1.06E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:-3.48|P-value:2.82E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.51|P-value:1.81E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.81|P-value:5.40E-5 ID:SGTC_897|Compound:1000-0139|FD-Score:3.96|P-value:2.88E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:3.77|P-value:6.34E-5 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.04|P-value:9.69E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:-3.63|P-value:1.56E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.41|P-value:2.66E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:4.95|P-value:2.62E-7 ID:SGTC_1123|Compound:mangostin|FD-Score:3.12|P-value:7.33E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-4.92|P-value:4.87E-7 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.29|P-value:4.13E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.49|P-value:2.64E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.77|P-value:6.30E-5 ID:SGTC_1558|Compound:st069300|FD-Score:3.32|P-value:3.61E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:4.29|P-value:6.71E-6 ID:SGTC_1729|Compound:st035615|FD-Score:3.68|P-value:9.23E-5 ID:SGTC_1737|Compound:st035557|FD-Score:4.23|P-value:9.03E-6 ID:SGTC_1776|Compound:st049249|FD-Score:-3.43|P-value:3.35E-4 ID:SGTC_1781|Compound:st038725|FD-Score:5.34|P-value:3.25E-8 ID:SGTC_1793|Compound:st048256|FD-Score:-4.04|P-value:3.03E-5 ID:SGTC_1795|Compound:st049545|FD-Score:-4.87|P-value:6.14E-7 ID:SGTC_1796|Compound:st049173|FD-Score:-3.82|P-value:7.26E-5 ID:SGTC_1839|Compound:st053978|FD-Score:3.49|P-value:1.95E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.11|P-value:7.78E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.26|P-value:4.46E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.10|P-value:7.99E-4 ID:SGTC_2127|Compound:5253358|FD-Score:5.68|P-value:4.38E-9 ID:SGTC_2132|Compound:5317594|FD-Score:6.78|P-value:3.55E-12 ID:SGTC_2140|Compound:5586273|FD-Score:3.26|P-value:4.56E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.13|P-value:7.19E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-3.72|P-value:1.10E-4 ID:SGTC_2423|Compound:st077119|FD-Score:3.51|P-value:1.82E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.19|P-value:5.87E-4 ID:SGTC_2446|Compound:5162541|FD-Score:3.11|P-value:7.71E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.69|P-value:8.96E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.30|P-value:5.26E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.24|P-value:6.69E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.17|P-value:8.28E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.07|P-value:8.92E-4 ID:SGTC_2717|Compound:st081029|FD-Score:-3.23|P-value:6.74E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-3.34|P-value:4.60E-4 ID:SGTC_3111|Compound:9122088|FD-Score:-4.09|P-value:2.40E-5 ID:SGTC_3148|Compound:9097893|FD-Score:3.46|P-value:2.14E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.94|P-value:3.21E-5 ID:SGTC_3212|Compound:9128307|FD-Score:3.32|P-value:3.60E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.76|P-value:9.55E-5 ID:SGTC_3314|Compound:9135860|FD-Score:-3.46|P-value:2.99E-4

Top fitness defect scores for YML024W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2132 5317594 6.78 122.7 µM 3.55E-12 SWF1 & branched chain AA biosynthesis 8 5.90E-12
2 SGTC_2127 5253358 5.68 187.9 µM 4.38E-9 3 6.54E-9
3 SGTC_1781 st038725 5.34 66.3 µM 3.25E-8 NEO1 66 4.71E-8
4 SGTC_1088 bifonazole 4.95 369.0 nM 2.62E-7 4 3.66E-7
5 SGTC_118 0083-0097 4.60 135.3 µM 1.56E-6 translation 81 2.11E-6
6 SGTC_1588 farnesol 4.29 29.9 µM 6.71E-6 4 8.89E-6
7 SGTC_1737 st035557 4.23 69.7 µM 9.03E-6 13 1.19E-5
8 SGTC_375 3970-0961 4.19 9.3 µM 1.06E-5 tubulin folding & SWR complex 14 1.40E-5
9 SGTC_195 4234-0266 4.18 16.6 µM 1.10E-5 27 1.45E-5
10 SGTC_897 1000-0139 3.96 31.4 µM 2.88E-5 27 3.71E-5
11 SGTC_3211 9128781 3.94 49.5 µM 3.21E-5 57 4.14E-5
12 SGTC_615 k087-0205 3.81 167.0 µM 5.40E-5 13 6.90E-5
13 SGTC_1529 apigenin 3.77 74.0 µM 6.30E-5 38 8.02E-5
14 SGTC_966 1300-0360 3.77 30.2 µM 6.34E-5 heme requiring 28 8.06E-5
15 SGTC_2566 crystal violet carbinol 3.69 226.0 nM 8.96E-5 50 1.13E-4
16 SGTC_1729 st035615 3.68 46.0 µM 9.23E-5 43 1.17E-4
17 SGTC_385 1494-0393 3.51 12.4 µM 1.81E-4 43 2.26E-4
18 SGTC_2423 st077119 3.51 87.2 µM 1.82E-4 21 2.27E-4
19 SGTC_1839 st053978 3.49 48.0 µM 1.95E-4 24 2.43E-4
20 SGTC_3148 9097893 3.46 49.5 µM 2.14E-4 53 2.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 9.36E-13 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.120 3.33E-12 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.108 3.87E-10 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.106 7.47E-10 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.103 1.84E-9 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.103 1.99E-9 YER074W RPS24A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication
0.103 2.54E-9 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.102 3.19E-9 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.097 1.67E-8 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.094 4.32E-8 YKR007W MEH1 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
0.087 3.84E-7 YLR264C-A_p YLR264C-A_p hom Putative protein of unknown function
0.086 6.69E-7 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.086 6.79E-7 YOR078W BUD21 hom Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern
0.085 9.39E-7 YML036W CGI121 hom Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification
0.083 1.32E-6 YDR024W_d FYV1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin