Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YML025C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.315 | 2.61E-78 | YGL114W_p | YGL114W_p | hom | Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters |
0.264 | 1.77E-54 | YPL246C | RBD2 | hom | Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p |
0.262 | 1.35E-53 | YHL045W_d | YHL045W_d | hom | Putative protein of unknown function; not an essential gene |
0.256 | 1.94E-51 | YML029W | USA1 | hom | Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p |
0.239 | 1.26E-44 | YDL155W | CLB3 | hom | B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress |
0.231 | 1.09E-41 | YOR271C_p | FSF1_p | hom | Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis |
0.230 | 1.18E-41 | YLR040C_p | YLR040C_p | hom | Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential |
0.225 | 1.09E-39 | YIL009W | FAA3 | hom | Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery |
0.222 | 9.82E-39 | YDR242W | AMD2 | hom | Putative amidase |
0.215 | 2.96E-36 | YGR251W | NOP19 | het | Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes |
0.201 | 4.78E-32 | YPR088C | SRP54 | het | Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain |
0.199 | 2.97E-31 | YDL022W | GPD1 | hom | NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity |
0.194 | 8.39E-30 | YLR317W_d | YLR317W_d | het | Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C |
0.193 | 1.45E-29 | YIR035C_p | YIR035C_p | hom | Putative cytoplasmic short-chain dehydrogenase/reductase |
0.188 | 4.01E-28 | YNR070W_p | PDR18_p | hom | Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |