Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YML034W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.592 | 4.71E-316 | YML034C-A_d | YML034C-A_d | hom | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.538 | 1.50E-250 | YDL183C | YDL183C | hom | Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene |
0.521 | 3.22E-233 | YOR254C | SEC63 | het | Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER |
0.489 | 3.76E-201 | YPR146C_d | YPR146C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.474 | 1.99E-187 | YER041W | YEN1 | hom | Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p |
0.463 | 1.26E-177 | YJL193W_p | YJL193W_p | hom | Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect |
0.460 | 1.64E-175 | YPR064W_d | YPR064W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.455 | 1.53E-170 | YCL014W | BUD3 | hom | Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding |
0.446 | 2.11E-163 | YFR007W | YFH7 | hom | Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases |
0.446 | 1.99E-163 | YJL155C | FBP26 | hom | Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress |
0.435 | 1.03E-154 | YMR110C | HFD1 | hom | Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder |
0.431 | 2.08E-151 | YDR537C_d | YDR537C_d | hom | Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W |
0.428 | 1.23E-149 | YPR065W | ROX1 | hom | Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance |
0.421 | 2.80E-144 | YLR201C | COQ9 | hom | Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes |
0.421 | 6.12E-144 | YGL119W | COQ8 | hom | Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication |