HIPHOP chemogenomics database

YML034W / SRC1

Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance

Zygosity: Homozygous strain

fixedexpanded
Profile for YML034W / SRC1

Click on Significant Values for Screen Details

Top fitness defect scores for YML034W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_142	0335-0849	19.30	62.7 µM	4.55E-68	ubiquinone biosynthesis & proteasome	6	6.49E-83
2	SGTC_794	k038-0031	18.30	316.0 µM	1.36E-61	ubiquinone biosynthesis & proteasome	2	5.36E-75
3	SGTC_158	k038-0087	18.00	26.4 µM	7.48E-60	ubiquinone biosynthesis & proteasome	8	7.17E-73
4	SGTC_984	1492-0255	17.60	2.9 µM	2.75E-57	SWF1 & branched chain AA biosynthesis	2	9.81E-70
5	SGTC_86	0417-1630	16.50	471.9 µM	1.14E-50	ubiquinone biosynthesis & proteasome	13	1.20E-61
6	SGTC_107	0358-0022	16.30	2.7 µM	1.78E-49	SWF1 & branched chain AA biosynthesis	4	3.46E-60
7	SGTC_137	0438-0332	16.00	85.4 µM	1.94E-47	ubiquinone biosynthesis & proteasome	12	1.08E-57
8	SGTC_64	000l-0018	10.80	272.1 µM	8.84E-23	ubiquinone biosynthesis & proteasome	34	1.51E-27
9	SGTC_7	0192-1582	10.80	4.2 µM	1.18E-22		6	2.13E-27
10	SGTC_642	0335-0876	10.70	158.0 µM	2.88E-22	ubiquinone biosynthesis & proteasome	6	6.38E-27
11	SGTC_294	k038-0071	10.50	157.0 µM	2.10E-21	ubiquinone biosynthesis & proteasome	1	7.24E-26
12	SGTC_255	tunicamycin	9.55	200.5 nM	3.72E-18	unfolded protein response	13	6.76E-22
13	SGTC_200	k038-0079	9.41	37.5 µM	1.06E-17	ubiquinone biosynthesis & proteasome	10	2.43E-21
14	SGTC_305	1682-2595	9.35	20.8 µM	1.78E-17	RNA processing & uracil transport	3	4.59E-21
15	SGTC_571	k831-0106	9.17	44.2 µM	6.61E-17		1	2.28E-20
16	SGTC_188	3229-0966	9.06	278.5 µM	1.56E-16		1	6.49E-20
17	SGTC_23	0213-0011	8.09	40.0 µM	1.55E-13	copper-dependent oxidative stress	6	3.00E-16
18	SGTC_2974	9094440	7.74	9.7 µM	1.55E-12	ergosterol biosynthesis	3	4.99E-15
19	SGTC_1161	k007-0610	7.46	110.0 µM	8.97E-12	ERAD & cell cycle	33	4.27E-14
20	SGTC_3059	1327-0034	7.39	3.0 µM	1.36E-11		21	7.12E-14

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.592	4.71E-316	YML034C-A_d	YML034C-A_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.538	1.50E-250	YDL183C	YDL183C	hom	Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.521	3.22E-233	YOR254C	SEC63	het	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.489	3.76E-201	YPR146C_d	YPR146C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.474	1.99E-187	YER041W	YEN1	hom	Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.463	1.26E-177	YJL193W_p	YJL193W_p	hom	Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.460	1.64E-175	YPR064W_d	YPR064W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.455	1.53E-170	YCL014W	BUD3	hom	Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.446	2.11E-163	YFR007W	YFH7	hom	Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.446	1.99E-163	YJL155C	FBP26	hom	Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.435	1.03E-154	YMR110C	HFD1	hom	Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.431	2.08E-151	YDR537C_d	YDR537C_d	hom	Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.428	1.23E-149	YPR065W	ROX1	hom	Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.421	2.80E-144	YLR201C	COQ9	hom	Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.421	6.12E-144	YGL119W	COQ8	hom	Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication