YML042W / CAT2

Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes

Zygosity: Homozygous strain
fixedexpanded
Profile for YML042W / CAT2

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:3.08|P-value:7.35E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:3.49|P-value:1.59E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.35|P-value:3.00E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.04|P-value:9.38E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.50|P-value:1.55E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.30|P-value:3.25E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:-3.16|P-value:6.18E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.93|P-value:2.50E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.29|P-value:3.79E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:-3.14|P-value:6.47E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-4.57|P-value:1.41E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:3.36|P-value:2.66E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:5.49|P-value:7.92E-9 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.15|P-value:5.83E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.92|P-value:2.59E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.73|P-value:6.25E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.21|P-value:5.07E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.17|P-value:5.26E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:4.20|P-value:7.48E-6 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.32|P-value:3.31E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:-3.05|P-value:8.92E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.23|P-value:4.26E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.46|P-value:1.76E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.58|P-value:1.11E-4 ID:SGTC_2018|Compound:5133068|FD-Score:5.19|P-value:4.56E-8 ID:SGTC_2019|Compound:4016004|FD-Score:3.64|P-value:8.76E-5 ID:SGTC_2023|Compound:5144124|FD-Score:3.09|P-value:7.12E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.62|P-value:9.60E-5 ID:SGTC_2127|Compound:5253358|FD-Score:-3.14|P-value:6.54E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.17|P-value:5.44E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-3.32|P-value:3.33E-4 ID:SGTC_2481|Compound:5478948|FD-Score:-3.36|P-value:2.92E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-4.49|P-value:2.06E-6 ID:SGTC_2961|Compound:9083290|FD-Score:3.85|P-value:3.65E-5 ID:SGTC_3004|Compound:9076122|FD-Score:-3.27|P-value:4.01E-4 ID:SGTC_3124|Compound:9127567|FD-Score:-7.57|P-value:4.06E-15 ID:SGTC_3131|Compound:9127911|FD-Score:-6.47|P-value:1.58E-11 ID:SGTC_3134|Compound:9127454|FD-Score:6.58|P-value:6.07E-12 ID:SGTC_3135|Compound:9127742|FD-Score:9.25|P-value:8.74E-22 ID:SGTC_3192|Compound:9110362|FD-Score:3.13|P-value:6.23E-4 ID:SGTC_3193|Compound:9111931|FD-Score:4.14|P-value:9.83E-6 ID:SGTC_3223|Compound:9129970|FD-Score:3.47|P-value:1.75E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-3.60|P-value:1.13E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:3.08|P-value:7.35E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:3.49|P-value:1.59E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.35|P-value:3.00E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.04|P-value:9.38E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:3.50|P-value:1.55E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.30|P-value:3.25E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:-3.16|P-value:6.18E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.93|P-value:2.50E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.29|P-value:3.79E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:-3.14|P-value:6.47E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-4.57|P-value:1.41E-6 ID:SGTC_948|Compound:3448-0295|FD-Score:3.36|P-value:2.66E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:5.49|P-value:7.92E-9 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.15|P-value:5.83E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.92|P-value:2.59E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.73|P-value:6.25E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.21|P-value:5.07E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.17|P-value:5.26E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:4.20|P-value:7.48E-6 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.32|P-value:3.31E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:-3.05|P-value:8.92E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.23|P-value:4.26E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.46|P-value:1.76E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.58|P-value:1.11E-4 ID:SGTC_2018|Compound:5133068|FD-Score:5.19|P-value:4.56E-8 ID:SGTC_2019|Compound:4016004|FD-Score:3.64|P-value:8.76E-5 ID:SGTC_2023|Compound:5144124|FD-Score:3.09|P-value:7.12E-4 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:3.62|P-value:9.60E-5 ID:SGTC_2127|Compound:5253358|FD-Score:-3.14|P-value:6.54E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.17|P-value:5.44E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-3.32|P-value:3.33E-4 ID:SGTC_2481|Compound:5478948|FD-Score:-3.36|P-value:2.92E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-4.49|P-value:2.06E-6 ID:SGTC_2961|Compound:9083290|FD-Score:3.85|P-value:3.65E-5 ID:SGTC_3004|Compound:9076122|FD-Score:-3.27|P-value:4.01E-4 ID:SGTC_3124|Compound:9127567|FD-Score:-7.57|P-value:4.06E-15 ID:SGTC_3131|Compound:9127911|FD-Score:-6.47|P-value:1.58E-11 ID:SGTC_3134|Compound:9127454|FD-Score:6.58|P-value:6.07E-12 ID:SGTC_3135|Compound:9127742|FD-Score:9.25|P-value:8.74E-22 ID:SGTC_3192|Compound:9110362|FD-Score:3.13|P-value:6.23E-4 ID:SGTC_3193|Compound:9111931|FD-Score:4.14|P-value:9.83E-6 ID:SGTC_3223|Compound:9129970|FD-Score:3.47|P-value:1.75E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-3.60|P-value:1.13E-4

Top fitness defect scores for YML042W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3135 9127742 9.25 49.5 µM 8.74E-22 1 1.15E-20
2 SGTC_3134 9127454 6.58 49.5 µM 6.07E-12 2 2.33E-11
3 SGTC_1033 k072-0102 5.49 21.3 µM 7.92E-9 60S ribosome export 4 2.06E-8
4 SGTC_2018 5133068 5.19 143.0 µM 4.56E-8 6 1.08E-7
5 SGTC_1347 1493-0251 4.20 600.0 nM 7.48E-6 mitochondrial response to ROS 13 1.34E-5
6 SGTC_3193 9111931 4.14 49.5 µM 9.83E-6 21 1.74E-5
7 SGTC_440 fluspirilene 3.93 35.1 µM 2.50E-5 13 4.20E-5
8 SGTC_1077 5-fluorocytosine 3.92 377.0 nM 2.59E-5 exosome 16 4.35E-5
9 SGTC_2961 9083290 3.85 32.5 µM 3.65E-5 19 6.01E-5
10 SGTC_2019 4016004 3.64 108.0 µM 8.76E-5 39 1.38E-4
11 SGTC_2091 4-phenylthiadiazole 3.62 200.0 µM 9.60E-5 25 1.50E-4
12 SGTC_2013 4024628 3.58 200.0 µM 1.11E-4 59 1.72E-4
13 SGTC_130 0136-0219 3.50 337.7 µM 1.55E-4 36 2.37E-4
14 SGTC_32 0928-0142 3.49 34.1 µM 1.59E-4 TSC3-RPN4 12 2.42E-4
15 SGTC_3223 9129970 3.47 49.5 µM 1.75E-4 33 2.65E-4
16 SGTC_1842 st055362 3.46 61.2 µM 1.76E-4 24 2.67E-4
17 SGTC_948 3448-0295 3.36 75.3 µM 2.66E-4 54 3.94E-4
18 SGTC_380 3970-0968 3.30 6.0 µM 3.25E-4 34 4.76E-4
19 SGTC_1526 st051518 3.23 75.0 µM 4.26E-4 45 6.15E-4
20 SGTC_1322 1348-1070 3.17 12.0 µM 5.26E-4 24 7.50E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.181 4.15E-26 YBR194W AIM4 hom Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress
0.152 7.59E-19 YER011W TIR1 hom Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
0.145 3.01E-17 YMR019W STB4 hom Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay;
0.116 1.52E-11 YJL211C_d YJL211C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2
0.111 9.74E-11 YPR026W ATH1 hom Acid trehalase required for utilization of extracellular trehalose
0.104 1.39E-9 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.104 1.60E-9 YPL264C_p YPL264C_p hom Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene
0.104 1.71E-9 YNL304W YPT11 hom Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells
0.101 4.12E-9 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.099 8.31E-9 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.099 8.46E-9 YOR308C SNU66 hom Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1
0.097 1.85E-8 YJL122W ALB1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
0.095 2.99E-8 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.095 3.71E-8 YNL082W PMS1 hom ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL
0.091 1.40E-7 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress