YML047C / PRM6

Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family

Zygosity: Homozygous strain
fixedexpanded
Profile for YML047C / PRM6

Click on Significant Values for Screen Details ID:SGTC_160|Compound:3453-0671|FD-Score:3.17|P-value:3.70E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:3.44|P-value:1.25E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.27|P-value:2.30E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.73|P-value:3.51E-5 ID:SGTC_179|Compound:1273-0063|FD-Score:-4.83|P-value:1.19E-7 ID:SGTC_180|Compound:1486-1293|FD-Score:3.26|P-value:2.54E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.15|P-value:4.02E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.36|P-value:1.72E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.00|P-value:6.93E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.99|P-value:1.06E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:3.00|P-value:7.04E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:2.96|P-value:8.09E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.32|P-value:2.01E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-3.29|P-value:2.14E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.40|P-value:1.37E-4 ID:SGTC_1771|Compound:st048882|FD-Score:-3.23|P-value:2.71E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.16|P-value:3.82E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.32|P-value:1.99E-4 ID:SGTC_2014|Compound:4013930|FD-Score:4.02|P-value:9.37E-6 ID:SGTC_2020|Compound:4017018|FD-Score:-2.98|P-value:7.01E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.24|P-value:2.78E-4 ID:SGTC_2183|Compound:6420625|FD-Score:-3.13|P-value:3.98E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-4.94|P-value:6.14E-8 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.18|P-value:3.56E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:2.93|P-value:9.10E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-4.31|P-value:2.01E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.96|P-value:6.34E-8 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.75|P-value:2.96E-5 ID:SGTC_2836|Compound:9010338|FD-Score:3.02|P-value:6.39E-4 ID:SGTC_2890|Compound:9046729|FD-Score:-2.94|P-value:8.25E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-4.19|P-value:3.70E-6 ID:SGTC_3146|Compound:9095609|FD-Score:3.72|P-value:3.78E-5 ID:SGTC_3147|Compound:9097027|FD-Score:4.19|P-value:4.01E-6 ID:SGTC_3277|Compound:9138724|FD-Score:-2.99|P-value:6.72E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.52|P-value:8.95E-5 ID:SGTC_3355|Compound:9151058|FD-Score:-3.15|P-value:3.73E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.17|P-value:3.70E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:3.44|P-value:1.25E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.27|P-value:2.30E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.73|P-value:3.51E-5 ID:SGTC_179|Compound:1273-0063|FD-Score:-4.83|P-value:1.19E-7 ID:SGTC_180|Compound:1486-1293|FD-Score:3.26|P-value:2.54E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.15|P-value:4.02E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.36|P-value:1.72E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.00|P-value:6.93E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.99|P-value:1.06E-5 ID:SGTC_815|Compound:1582-0027|FD-Score:3.00|P-value:7.04E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:2.96|P-value:8.09E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.32|P-value:2.01E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-3.29|P-value:2.14E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.40|P-value:1.37E-4 ID:SGTC_1771|Compound:st048882|FD-Score:-3.23|P-value:2.71E-4 ID:SGTC_1784|Compound:st039334|FD-Score:3.16|P-value:3.82E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.32|P-value:1.99E-4 ID:SGTC_2014|Compound:4013930|FD-Score:4.02|P-value:9.37E-6 ID:SGTC_2020|Compound:4017018|FD-Score:-2.98|P-value:7.01E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.24|P-value:2.78E-4 ID:SGTC_2183|Compound:6420625|FD-Score:-3.13|P-value:3.98E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-4.94|P-value:6.14E-8 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.18|P-value:3.56E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:2.93|P-value:9.10E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-4.31|P-value:2.01E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.96|P-value:6.34E-8 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.75|P-value:2.96E-5 ID:SGTC_2836|Compound:9010338|FD-Score:3.02|P-value:6.39E-4 ID:SGTC_2890|Compound:9046729|FD-Score:-2.94|P-value:8.25E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-4.19|P-value:3.70E-6 ID:SGTC_3146|Compound:9095609|FD-Score:3.72|P-value:3.78E-5 ID:SGTC_3147|Compound:9097027|FD-Score:4.19|P-value:4.01E-6 ID:SGTC_3277|Compound:9138724|FD-Score:-2.99|P-value:6.72E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.52|P-value:8.95E-5 ID:SGTC_3355|Compound:9151058|FD-Score:-3.15|P-value:3.73E-4

Top fitness defect scores for YML047C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2612 dictamnine 4.96 15.5 µM 6.34E-8 RNA pol III & RNase P/MRP 24 3.60E-7
2 SGTC_3147 9097027 4.19 49.5 µM 4.01E-6 16 1.40E-5
3 SGTC_2014 4013930 4.02 200.0 µM 9.37E-6 28 2.96E-5
4 SGTC_536 3852-0578 3.99 10.6 µM 1.06E-5 21 3.30E-5
5 SGTC_170 4197-0004 3.73 226.0 µM 3.51E-5 21 9.52E-5
6 SGTC_3146 9095609 3.72 49.5 µM 3.78E-5 21 1.02E-4
7 SGTC_3337 9144342 3.52 33.5 µM 8.95E-5 40 2.18E-4
8 SGTC_162 k030-0015 3.44 37.8 µM 1.25E-4 iron homeostasis 31 2.93E-4
9 SGTC_369 0957-0393 3.36 4.5 µM 1.72E-4 cell wall signaling 49 3.88E-4
10 SGTC_1998 st075797 3.32 76.8 µM 1.99E-4 mitochondrial response to ROS 35 4.43E-4
11 SGTC_947 3447-0010 3.32 211.0 µM 2.01E-4 32 4.46E-4
12 SGTC_180 1486-1293 3.26 102.8 µM 2.54E-4 62 5.49E-4
13 SGTC_2170 morpholine 3.24 200.0 µM 2.78E-4 30 5.95E-4
14 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 3.18 100.0 µM 3.56E-4 48 7.41E-4
15 SGTC_160 3453-0671 3.17 289.7 µM 3.70E-4 73 7.67E-4
16 SGTC_1784 st039334 3.16 36.3 µM 3.82E-4 47 7.88E-4
17 SGTC_307 1501-1223 3.15 22.3 µM 4.02E-4 36 8.25E-4
18 SGTC_2836 9010338 3.02 19.5 µM 6.39E-4 RPP1 & pyrimidine depletion 83 0.00124
19 SGTC_429 1112-0049 3.00 25.5 µM 6.93E-4 DNA damage response 80 0.00134
20 SGTC_815 1582-0027 3.00 36.9 µM 7.04E-4 76 0.00136

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 8.80E-18 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.105 1.09E-9 YDR211W GCD6 het Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress
0.104 1.34E-9 YFL003C MSH4 hom Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein
0.104 1.74E-9 YOL138C RTC1 hom Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif
0.102 2.84E-9 YMR292W GOT1 hom Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition
0.102 3.85E-9 YBR148W YSW1 hom Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane
0.099 8.25E-9 YOR131C YOR131C hom Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress
0.097 1.92E-8 YGL111W NSA1 het Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
0.095 3.17E-8 YJL132W_p YJL132W_p hom Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene
0.095 3.67E-8 YJR005C-A_p YJR005C-A_p hom Putative protein of unknown function; originally identified as a syntenic homolog of an Ashbya gossypii gene; YJR005C-A has a paralog, YGR169C-A, that arose from the whole genome duplication
0.094 4.23E-8 YPL249C GYP5 hom GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.094 5.12E-8 YIL014W MNT3 hom Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation
0.094 5.57E-8 YBR285W_p YBR285W_p hom Putative protein of unknown function; YBR285W is not an essential gene
0.094 5.68E-8 YNL050C_p YNL050C_p hom Putative protein of unknown function; YNL050c is not an essential gene
0.093 6.60E-8 YBR019C GAL10 hom UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers