YML051W / GAL80

Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding

Zygosity: Homozygous strain
fixedexpanded
Profile for YML051W / GAL80

Click on Significant Values for Screen Details ID:SGTC_157|Compound:1348-1695|FD-Score:5.63|P-value:4.26E-8 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.61|P-value:3.60E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.73|P-value:1.82E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.75|P-value:2.21E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:-3.41|P-value:6.95E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.39|P-value:7.58E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.72|P-value:1.90E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.74|P-value:3.10E-6 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.55|P-value:4.46E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-4.78|P-value:3.52E-6 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.37|P-value:6.41E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.51|P-value:3.96E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.47|P-value:4.53E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.31|P-value:7.75E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.36|P-value:8.26E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.50|P-value:5.25E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.38|P-value:6.21E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.41|P-value:5.54E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-4.25|P-value:3.34E-5 ID:SGTC_2912|Compound:7964298|FD-Score:-3.42|P-value:6.74E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.49|P-value:5.38E-4 ID:SGTC_3262|Compound:9137218|FD-Score:4.18|P-value:3.37E-5 ID:SGTC_3264|Compound:9137442|FD-Score:-3.74|P-value:2.26E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:5.63|P-value:4.26E-8 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.61|P-value:3.60E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.73|P-value:1.82E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.75|P-value:2.21E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:-3.41|P-value:6.95E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.39|P-value:7.58E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.72|P-value:1.90E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.74|P-value:3.10E-6 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.55|P-value:4.46E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:-4.78|P-value:3.52E-6 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.37|P-value:6.41E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.51|P-value:3.96E-4 ID:SGTC_1783|Compound:st039459|FD-Score:3.47|P-value:4.53E-4 ID:SGTC_1841|Compound:st054148|FD-Score:3.31|P-value:7.75E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.36|P-value:8.26E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.50|P-value:5.25E-4 ID:SGTC_2116|Compound:5511452|FD-Score:3.38|P-value:6.21E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.41|P-value:5.54E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-4.25|P-value:3.34E-5 ID:SGTC_2912|Compound:7964298|FD-Score:-3.42|P-value:6.74E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.49|P-value:5.38E-4 ID:SGTC_3262|Compound:9137218|FD-Score:4.18|P-value:3.37E-5 ID:SGTC_3264|Compound:9137442|FD-Score:-3.74|P-value:2.26E-4

Top fitness defect scores for YML051W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_157 1348-1695 5.63 65.8 µM 4.26E-8 iron homeostasis 22 9.14E-9
2 SGTC_1049 3226-0134 4.74 66.0 µM 3.10E-6 13 1.05E-6
3 SGTC_3262 9137218 4.18 49.5 µM 3.37E-5 2 1.46E-5
4 SGTC_576 1073-0113 3.73 22.7 µM 1.82E-4 redox potentiating 70 9.43E-5
5 SGTC_945 3381-0768 3.72 11.3 µM 1.90E-4 endomembrane recycling 40 9.85E-5
6 SGTC_1370 2001-0092 3.51 44.6 µM 3.96E-4 52 2.21E-4
7 SGTC_1783 st039459 3.47 87.5 µM 4.53E-4 Golgi 34 2.56E-4
8 SGTC_2725 haloperidol 3.41 53.2 µM 5.54E-4 plasma membrane duress 58 3.20E-4
9 SGTC_2116 5511452 3.38 16.9 µM 6.21E-4 33 3.63E-4
10 SGTC_1165 k072-0275 3.37 30.3 µM 6.41E-4 61 3.76E-4
11 SGTC_1841 st054148 3.31 70.0 µM 7.75E-4 26 4.63E-4
12 SGTC_40 0327-0103 3.18 19.8 µM 0.00120 60 7.46E-4
13 SGTC_2538 3',7'-epoxycaryophyllan-6-one 3.17 100.0 µM 0.00123 48 7.72E-4
14 SGTC_869 0564-0080 3.16 44.1 µM 0.00125 51 7.82E-4
15 SGTC_2066 5222451 3.15 176.0 µM 0.00130 heme biosynthesis & mitochondrial translocase 70 8.17E-4
16 SGTC_1941 st076221 3.13 61.8 µM 0.00137 sphingolipid biosynthesis & PDR1 127 8.66E-4
17 SGTC_2581 avocatin a 3.09 64.0 µM 0.00156 sphingolipid biosynthesis & PDR1 90 9.97E-4
18 SGTC_1787 fluconazole 3.06 80.0 µM 0.00171 iron homeostasis 86 0.00110
19 SGTC_2630 antimycin a 3.06 100.0 µM 0.00173 mitochondrial processes 82 0.00112
20 SGTC_2662 daunorubicin 3.03 22.4 µM 0.00185 anthracycline transcription coupled DNA repair 46 0.00121

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.146 2.24E-17 YDR010C_d YDR010C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.144 4.09E-17 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.118 6.67E-12 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.106 6.86E-10 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.106 7.62E-10 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.104 1.48E-9 YER145C FTR1 hom High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
0.092 9.13E-8 YMR244W_p YMR244W_p hom Putative protein of unknown function
0.091 1.29E-7 YCR011C ADP1 hom Putative ATP-dependent permease of the ABC transporter family of proteins
0.090 1.66E-7 YNL259C ATX1 hom Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.087 4.21E-7 YBR101C FES1 hom Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.086 5.56E-7 YNL181W_p YNL181W_p het Putative oxidoreductase; required for cell viability
0.081 2.86E-6 YOR283W YOR283W hom Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene
0.079 4.31E-6 YFL041W-A_p YFL041W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.079 4.72E-6 YMR258C ROY1 hom GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p
0.075 1.21E-5 YOR185C GSP2 hom GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability; protein abundance increases in response to DNA replication stress