HIPHOP chemogenomics database

YML052W / SUR7

Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants

Zygosity: Homozygous strain

fixedexpanded
Profile for YML052W / SUR7

Click on Significant Values for Screen Details

Top fitness defect scores for YML052W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2582	agaric acid	15.40	100.0 µM	4.48E-67	redox potentiating	14	5.53E-54
2	SGTC_1239	0337-0584	4.69	35.4 µM	7.23E-8	unfolded protein response	33	1.37E-6
3	SGTC_2371	9071574	4.49	200.0 µM	2.31E-7		7	3.49E-6
4	SGTC_1241	0364-0022	4.40	50.8 µM	4.02E-7	ERG2	22	5.45E-6
5	SGTC_39	0986-0283	4.34	58.4 µM	5.68E-7	calcium & mitochondrial duress	28	7.19E-6
6	SGTC_2254	7938975	4.20	95.2 µM	1.19E-6		43	1.31E-5
7	SGTC_1132	3456-3614	4.15	2.5 µM	1.57E-6	tubulin folding & SWR complex	37	1.63E-5
8	SGTC_164	4100-3994	3.97	89.6 µM	4.13E-6		33	3.55E-5
9	SGTC_2494	18-aminoabieta-8,11,13-triene sulfate	3.79	3.7 µM	1.05E-5		94	7.54E-5
10	SGTC_637	1181-0519	3.66	7.3 µM	2.00E-5	fatty acid desaturase (OLE1)	120	1.27E-4
11	SGTC_2375	9072683	3.49	200.0 µM	4.38E-5	mitochondrial processes	29	2.38E-4
12	SGTC_2379	9035213	3.42	200.0 µM	6.11E-5		40	3.12E-4
13	SGTC_41	0478-0632	3.38	82.6 µM	7.42E-5		52	3.65E-4
14	SGTC_1678	st019265	3.34	80.2 µM	8.91E-5	60S ribosome export	45	4.23E-4
15	SGTC_2348	9022543	3.26	33.4 µM	1.23E-4	mitochondrial processes	50	5.48E-4
16	SGTC_3230	9131665	3.18	49.5 µM	1.80E-4		4	7.47E-4
17	SGTC_2282	7944268	3.08	200.0 µM	2.72E-4	RPP1 & pyrimidine depletion	85	0.00104
18	SGTC_2374	9071832	3.08	200.0 µM	2.73E-4	endomembrane recycling	31	0.00104
19	SGTC_3162	9099653	3.01	49.5 µM	3.60E-4		23	0.00131
20	SGTC_3133	9127736	3.00	49.5 µM	3.81E-4		58	0.00137

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.409	2.45E-135	YML103C	NUP188	hom	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.366	1.46E-106	YNL106C	INP52	hom	Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.355	3.81E-100	YNL027W	CRZ1	hom	Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.347	8.48E-96	YIL129C	TAO3	het	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.330	4.96E-86	YPL232W	SSO1	hom	Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.310	1.33E-75	YGR032W	GSC2	hom	Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
0.305	1.98E-73	YOR049C	RSB1	hom	Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.296	1.16E-68	YEL007W	MIT1	hom	Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.295	2.55E-68	YMR109W	MYO5	hom	One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.274	1.18E-58	YLR206W	ENT2	hom	Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.271	1.21E-57	YJR091C	JSN1	hom	Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl
0.269	1.44E-56	YNL074C	MLF3	hom	Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.264	9.95E-55	YNL105W_d	RRT16_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.261	3.21E-53	YOR050C_d	YOR050C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.246	2.50E-47	YPR023C	EAF3	hom	Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition