YML057C-A_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W

Zygosity: Homozygous strain
fixedexpanded
Profile for YML057C-A / YML057C-A

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:8.82|P-value:2.43E-24 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.37|P-value:6.35E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:7.54|P-value:2.49E-18 ID:SGTC_309|Compound:k408-0051|FD-Score:2.69|P-value:9.76E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:2.84|P-value:5.26E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.92|P-value:3.26E-6 ID:SGTC_635|Compound:k038-0028|FD-Score:3.05|P-value:2.23E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.78|P-value:8.07E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.36|P-value:5.41E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.02|P-value:2.52E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:7.90|P-value:6.54E-20 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-2.73|P-value:9.55E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:2.89|P-value:4.45E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:-3.09|P-value:2.18E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.26|P-value:8.66E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:-3.15|P-value:1.69E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.82|P-value:6.69E-6 ID:SGTC_1195|Compound:1502-0147|FD-Score:-2.92|P-value:4.48E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:2.92|P-value:3.89E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:-2.93|P-value:4.31E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.21|P-value:1.09E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.52|P-value:2.51E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.96|P-value:3.83E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:2.87|P-value:4.76E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.17|P-value:1.56E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-2.79|P-value:7.61E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.40|P-value:4.54E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.41|P-value:4.40E-5 ID:SGTC_2102|Compound:5377816|FD-Score:2.75|P-value:7.63E-4 ID:SGTC_2103|Compound:5378138|FD-Score:2.72|P-value:8.68E-4 ID:SGTC_2395|Compound:5646831|FD-Score:2.86|P-value:4.93E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.08|P-value:1.92E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-2.73|P-value:9.56E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.11|P-value:1.75E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.07|P-value:2.41E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.06|P-value:2.49E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.18|P-value:1.29E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.22|P-value:1.03E-4 ID:SGTC_2820|Compound:7989630|FD-Score:3.13|P-value:1.55E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.85|P-value:5.75E-6 ID:SGTC_2850|Compound:9015429|FD-Score:-6.09|P-value:1.90E-12 ID:SGTC_2852|Compound:9023854|FD-Score:-4.01|P-value:2.53E-6 ID:SGTC_2857|Compound:9024691|FD-Score:-4.60|P-value:8.25E-8 ID:SGTC_2918|Compound:7977171|FD-Score:3.68|P-value:1.18E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-2.86|P-value:5.87E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-3.76|P-value:9.48E-6 ID:SGTC_2928|Compound:9011484|FD-Score:3.64|P-value:1.44E-5 ID:SGTC_2971|Compound:9092186|FD-Score:-4.59|P-value:8.51E-8 ID:SGTC_3061|Compound:glucosamine|FD-Score:2.72|P-value:8.75E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-2.77|P-value:8.24E-4 ID:SGTC_3237|Compound:9133362|FD-Score:3.22|P-value:1.05E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.82|P-value:2.43E-24 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.37|P-value:6.35E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:7.54|P-value:2.49E-18 ID:SGTC_309|Compound:k408-0051|FD-Score:2.69|P-value:9.76E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:2.84|P-value:5.26E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.92|P-value:3.26E-6 ID:SGTC_635|Compound:k038-0028|FD-Score:3.05|P-value:2.23E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-2.78|P-value:8.07E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.36|P-value:5.41E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:3.02|P-value:2.52E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:7.90|P-value:6.54E-20 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-2.73|P-value:9.55E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:2.89|P-value:4.45E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:-3.09|P-value:2.18E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.26|P-value:8.66E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:-3.15|P-value:1.69E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.82|P-value:6.69E-6 ID:SGTC_1195|Compound:1502-0147|FD-Score:-2.92|P-value:4.48E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:2.92|P-value:3.89E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:-2.93|P-value:4.31E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.21|P-value:1.09E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.52|P-value:2.51E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.96|P-value:3.83E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:2.87|P-value:4.76E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.17|P-value:1.56E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-2.79|P-value:7.61E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.40|P-value:4.54E-5 ID:SGTC_1941|Compound:st076221|FD-Score:3.41|P-value:4.40E-5 ID:SGTC_2102|Compound:5377816|FD-Score:2.75|P-value:7.63E-4 ID:SGTC_2103|Compound:5378138|FD-Score:2.72|P-value:8.68E-4 ID:SGTC_2395|Compound:5646831|FD-Score:2.86|P-value:4.93E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.08|P-value:1.92E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-2.73|P-value:9.56E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.11|P-value:1.75E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.07|P-value:2.41E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.06|P-value:2.49E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.18|P-value:1.29E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.22|P-value:1.03E-4 ID:SGTC_2820|Compound:7989630|FD-Score:3.13|P-value:1.55E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.85|P-value:5.75E-6 ID:SGTC_2850|Compound:9015429|FD-Score:-6.09|P-value:1.90E-12 ID:SGTC_2852|Compound:9023854|FD-Score:-4.01|P-value:2.53E-6 ID:SGTC_2857|Compound:9024691|FD-Score:-4.60|P-value:8.25E-8 ID:SGTC_2918|Compound:7977171|FD-Score:3.68|P-value:1.18E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-2.86|P-value:5.87E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-3.76|P-value:9.48E-6 ID:SGTC_2928|Compound:9011484|FD-Score:3.64|P-value:1.44E-5 ID:SGTC_2971|Compound:9092186|FD-Score:-4.59|P-value:8.51E-8 ID:SGTC_3061|Compound:glucosamine|FD-Score:2.72|P-value:8.75E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-2.77|P-value:8.24E-4 ID:SGTC_3237|Compound:9133362|FD-Score:3.22|P-value:1.05E-4

Top fitness defect scores for YML057C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 8.82 9.0 µM 2.43E-24 cell wall 104 5.72E-19
2 SGTC_1119 parthenolide 7.90 318.5 nM 6.54E-20 TSC3-RPN4 3 1.40E-15
3 SGTC_138 0850-0259 7.54 40.9 µM 2.49E-18 cell wall 68 2.26E-14
4 SGTC_527 4476-4215 3.92 268.0 µM 3.26E-6 PDR1 35 4.40E-5
5 SGTC_2918 7977171 3.68 22.1 µM 1.18E-5 35 1.19E-4
6 SGTC_2928 9011484 3.64 9.8 µM 1.44E-5 heme biosynthesis & mitochondrial translocase 42 1.38E-4
7 SGTC_1384 3089-0840 3.52 101.0 µM 2.51E-5 24 2.12E-4
8 SGTC_1941 st076221 3.41 61.8 µM 4.40E-5 sphingolipid biosynthesis & PDR1 109 3.26E-4
9 SGTC_1924 st058459 3.40 75.1 µM 4.54E-5 23 3.35E-4
10 SGTC_979 1426-2828 3.36 121.0 µM 5.41E-5 38 3.83E-4
11 SGTC_1175 0741-0056 3.26 27.6 µM 8.66E-5 51 5.51E-4
12 SGTC_2813 7971799 3.22 71.4 µM 1.03E-4 48 6.32E-4
13 SGTC_3237 9133362 3.22 49.5 µM 1.05E-4 57 6.37E-4
14 SGTC_1248 0469-0687 3.21 58.6 µM 1.09E-4 62 6.57E-4
15 SGTC_2750 bromebric acid 3.18 70.2 µM 1.29E-4 72 7.48E-4
16 SGTC_2820 7989630 3.13 71.4 µM 1.55E-4 ERG2 48 8.63E-4
17 SGTC_2563 tomatine 3.11 8.5 µM 1.75E-4 96 9.47E-4
18 SGTC_2399 5884133 3.08 200.0 µM 1.92E-4 cell wall signaling 122 0.00102
19 SGTC_635 k038-0028 3.05 24.7 µM 2.23E-4 ubiquinone biosynthesis & proteasome 93 0.00115
20 SGTC_1028 k015-0029 3.02 4.8 µM 2.52E-4 67 0.00126

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.347 1.56E-95 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.317 2.09E-79 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.310 8.29E-76 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.307 2.00E-74 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.272 4.79E-58 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.267 7.35E-56 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
0.262 1.05E-53 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.257 1.51E-51 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.256 1.82E-51 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.253 2.61E-50 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.252 1.45E-49 YJL059W YHC3 hom Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis)
0.251 3.11E-49 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.244 8.68E-47 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.238 2.39E-44 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.237 3.01E-44 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain