YML057W / CMP2

Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1

Zygosity: Homozygous strain
fixedexpanded
Profile for YML057W / CMP2

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-2.88|P-value:6.45E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:9.44|P-value:5.76E-27 ID:SGTC_301|Compound:4119-0100|FD-Score:-2.86|P-value:6.99E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:2.72|P-value:9.63E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.03|P-value:2.36E-6 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.29|P-value:1.15E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.69|P-value:1.39E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:-4.20|P-value:1.24E-6 ID:SGTC_955|Compound:1216-0110|FD-Score:-2.94|P-value:5.16E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:4.41|P-value:2.75E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:5.27|P-value:1.17E-9 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.44|P-value:4.65E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.97|P-value:8.60E-9 ID:SGTC_1808|Compound:st050063|FD-Score:2.77|P-value:8.11E-4 ID:SGTC_1813|Compound:st051246|FD-Score:2.87|P-value:5.40E-4 ID:SGTC_1843|Compound:st055809|FD-Score:2.86|P-value:5.68E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-2.86|P-value:6.98E-4 ID:SGTC_1902|Compound:st060212|FD-Score:3.43|P-value:4.73E-5 ID:SGTC_1903|Compound:st060211|FD-Score:2.87|P-value:5.49E-4 ID:SGTC_1994|Compound:st072947|FD-Score:2.79|P-value:7.48E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-2.83|P-value:7.84E-4 ID:SGTC_2425|Compound:5628681|FD-Score:2.79|P-value:7.34E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.60|P-value:2.08E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:-2.91|P-value:5.82E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-2.98|P-value:4.37E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-6.90|P-value:4.31E-15 ID:SGTC_2564|Compound:betulinic acid|FD-Score:2.81|P-value:6.87E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-2.89|P-value:6.17E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.59|P-value:2.20E-5 ID:SGTC_2716|Compound:st080858|FD-Score:2.95|P-value:3.93E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:-3.57|P-value:3.26E-5 ID:SGTC_2791|Compound:5663188|FD-Score:2.95|P-value:3.85E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.06|P-value:3.06E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.58|P-value:2.32E-5 ID:SGTC_2846|Compound:9008642|FD-Score:4.35|P-value:3.96E-7 ID:SGTC_2858|Compound:9025781|FD-Score:4.72|P-value:4.36E-8 ID:SGTC_3189|Compound:9110682|FD-Score:3.13|P-value:1.86E-4 ID:SGTC_3196|Compound:9111891|FD-Score:4.85|P-value:1.84E-8 ID:SGTC_3221|Compound:9128209|FD-Score:3.67|P-value:1.52E-5 ID:SGTC_3271|Compound:9137798|FD-Score:2.74|P-value:9.00E-4 ID:SGTC_3287|Compound:9117173|FD-Score:2.78|P-value:7.69E-4 ID:SGTC_3290|Compound:9121031|FD-Score:2.82|P-value:6.47E-4 ID:SGTC_3344|Compound:9148862|FD-Score:-2.92|P-value:5.40E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-2.88|P-value:6.45E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:9.44|P-value:5.76E-27 ID:SGTC_301|Compound:4119-0100|FD-Score:-2.86|P-value:6.99E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:2.72|P-value:9.63E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.03|P-value:2.36E-6 ID:SGTC_819|Compound:1013-0258|FD-Score:-3.29|P-value:1.15E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.69|P-value:1.39E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:-4.20|P-value:1.24E-6 ID:SGTC_955|Compound:1216-0110|FD-Score:-2.94|P-value:5.16E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:4.41|P-value:2.75E-7 ID:SGTC_961|Compound:1252-1571|FD-Score:5.27|P-value:1.17E-9 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.44|P-value:4.65E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.97|P-value:8.60E-9 ID:SGTC_1808|Compound:st050063|FD-Score:2.77|P-value:8.11E-4 ID:SGTC_1813|Compound:st051246|FD-Score:2.87|P-value:5.40E-4 ID:SGTC_1843|Compound:st055809|FD-Score:2.86|P-value:5.68E-4 ID:SGTC_1885|Compound:st057546|FD-Score:-2.86|P-value:6.98E-4 ID:SGTC_1902|Compound:st060212|FD-Score:3.43|P-value:4.73E-5 ID:SGTC_1903|Compound:st060211|FD-Score:2.87|P-value:5.49E-4 ID:SGTC_1994|Compound:st072947|FD-Score:2.79|P-value:7.48E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-2.83|P-value:7.84E-4 ID:SGTC_2425|Compound:5628681|FD-Score:2.79|P-value:7.34E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.60|P-value:2.08E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:-2.91|P-value:5.82E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-2.98|P-value:4.37E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-6.90|P-value:4.31E-15 ID:SGTC_2564|Compound:betulinic acid|FD-Score:2.81|P-value:6.87E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-2.89|P-value:6.17E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.59|P-value:2.20E-5 ID:SGTC_2716|Compound:st080858|FD-Score:2.95|P-value:3.93E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:-3.57|P-value:3.26E-5 ID:SGTC_2791|Compound:5663188|FD-Score:2.95|P-value:3.85E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.06|P-value:3.06E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.58|P-value:2.32E-5 ID:SGTC_2846|Compound:9008642|FD-Score:4.35|P-value:3.96E-7 ID:SGTC_2858|Compound:9025781|FD-Score:4.72|P-value:4.36E-8 ID:SGTC_3189|Compound:9110682|FD-Score:3.13|P-value:1.86E-4 ID:SGTC_3196|Compound:9111891|FD-Score:4.85|P-value:1.84E-8 ID:SGTC_3221|Compound:9128209|FD-Score:3.67|P-value:1.52E-5 ID:SGTC_3271|Compound:9137798|FD-Score:2.74|P-value:9.00E-4 ID:SGTC_3287|Compound:9117173|FD-Score:2.78|P-value:7.69E-4 ID:SGTC_3290|Compound:9121031|FD-Score:2.82|P-value:6.47E-4 ID:SGTC_3344|Compound:9148862|FD-Score:-2.92|P-value:5.40E-4

Top fitness defect scores for YML057W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 9.44 9.0 µM 5.76E-27 cell wall 91 1.78E-21
2 SGTC_961 1252-1571 5.27 372.0 µM 1.17E-9 14 6.99E-8
3 SGTC_1206 3978-0017 4.97 132.0 µM 8.60E-9 ERG2 16 3.36E-7
4 SGTC_3196 9111891 4.85 49.5 µM 1.84E-8 mitochondrial processes 7 6.12E-7
5 SGTC_2858 9025781 4.72 9.0 µM 4.36E-8 sphingolipid biosynthesis & PDR1 73 1.21E-6
6 SGTC_960 1222-0186 4.41 7.7 µM 2.75E-7 20 5.15E-6
7 SGTC_2846 9008642 4.35 19.5 µM 3.96E-7 17 6.86E-6
8 SGTC_457 grayanotoxin iii 4.03 135.0 µM 2.36E-6 62 2.81E-5
9 SGTC_821 1114-0266 3.69 29.2 µM 1.39E-5 24 1.14E-4
10 SGTC_3221 9128209 3.67 49.5 µM 1.52E-5 21 1.22E-4
11 SGTC_2479 5617353 3.60 43.9 µM 2.08E-5 52 1.56E-4
12 SGTC_2676 harmalol 3.59 100.0 µM 2.20E-5 mitochondrial processes 17 1.63E-4
13 SGTC_2835 9006588 3.58 71.4 µM 2.32E-5 56 1.71E-4
14 SGTC_1069 diphenylcyclopropenone 3.44 8.5 µM 4.65E-5 47 2.95E-4
15 SGTC_1902 st060212 3.43 70.5 µM 4.73E-5 23 2.99E-4
16 SGTC_3189 9110682 3.13 49.5 µM 1.86E-4 66 8.84E-4
17 SGTC_2791 5663188 2.95 71.4 µM 3.85E-4 RPP1 & pyrimidine depletion 65 0.00157
18 SGTC_2716 st080858 2.95 38.6 µM 3.93E-4 60S ribosome export 54 0.00160
19 SGTC_1813 st051246 2.87 8.6 µM 5.40E-4 TSC3-RPN4 41 0.00206
20 SGTC_1903 st060211 2.87 78.3 µM 5.49E-4 86 0.00208

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.312 8.47E-77 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.292 4.96E-67 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.292 9.06E-67 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.262 1.29E-53 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.258 2.93E-52 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.257 1.13E-51 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.254 1.42E-50 YBR292C_d YBR292C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
0.253 2.56E-50 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.242 4.33E-46 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.236 7.93E-44 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.234 5.61E-43 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.229 3.37E-41 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.229 5.93E-41 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.224 2.30E-39 YGL066W SGF73 hom SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.220 7.09E-38 YNL016W PUB1 hom Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress