YML076C / WAR1

Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively

Zygosity: Homozygous strain
fixedexpanded
Profile for YML076C / WAR1

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:-3.61|P-value:6.62E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:3.42|P-value:1.08E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.34|P-value:2.01E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:2.86|P-value:9.66E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.31|P-value:1.69E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:3.58|P-value:5.54E-5 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.04|P-value:4.92E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.68|P-value:2.33E-7 ID:SGTC_793|Compound:0488-0545|FD-Score:3.17|P-value:3.04E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:4.06|P-value:6.02E-6 ID:SGTC_802|Compound:4112-3352|FD-Score:4.03|P-value:6.95E-6 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.15|P-value:4.26E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.79|P-value:2.09E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.38|P-value:1.75E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.60|P-value:6.72E-5 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.00|P-value:5.86E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.62|P-value:4.52E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.97|P-value:6.46E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.47|P-value:7.21E-7 ID:SGTC_1304|Compound:1165-0502|FD-Score:-2.93|P-value:9.65E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.87|P-value:1.45E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-4.53|P-value:7.73E-7 ID:SGTC_1613|Compound:st002381|FD-Score:-3.75|P-value:3.53E-5 ID:SGTC_1736|Compound:st036774|FD-Score:4.38|P-value:1.17E-6 ID:SGTC_1770|Compound:st043884|FD-Score:4.34|P-value:1.46E-6 ID:SGTC_1781|Compound:st038725|FD-Score:-3.08|P-value:5.71E-4 ID:SGTC_2328|Compound:6201408|FD-Score:3.90|P-value:1.27E-5 ID:SGTC_2329|Compound:6138490|FD-Score:5.22|P-value:9.59E-9 ID:SGTC_2347|Compound:9049783|FD-Score:8.17|P-value:8.46E-19 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.27|P-value:2.70E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.13|P-value:3.53E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.15|P-value:4.23E-4 ID:SGTC_2432|Compound:5630864|FD-Score:4.11|P-value:4.66E-6 ID:SGTC_2455|Compound:5377712|FD-Score:-2.93|P-value:9.85E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.09|P-value:5.51E-4 ID:SGTC_2624|Compound:nerol|FD-Score:2.91|P-value:8.27E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.21|P-value:2.58E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-6.88|P-value:1.26E-13 ID:SGTC_2956|Compound:9076196|FD-Score:-2.97|P-value:8.41E-4 ID:SGTC_3287|Compound:9117173|FD-Score:3.47|P-value:8.80E-5 ID:SGTC_31|Compound:0508-1974|FD-Score:-3.61|P-value:6.62E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:3.42|P-value:1.08E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.34|P-value:2.01E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:2.86|P-value:9.66E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.31|P-value:1.69E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:3.58|P-value:5.54E-5 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.04|P-value:4.92E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.68|P-value:2.33E-7 ID:SGTC_793|Compound:0488-0545|FD-Score:3.17|P-value:3.04E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:4.06|P-value:6.02E-6 ID:SGTC_802|Compound:4112-3352|FD-Score:4.03|P-value:6.95E-6 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.15|P-value:4.26E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.79|P-value:2.09E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.38|P-value:1.75E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.60|P-value:6.72E-5 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.00|P-value:5.86E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.62|P-value:4.52E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.97|P-value:6.46E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:4.47|P-value:7.21E-7 ID:SGTC_1304|Compound:1165-0502|FD-Score:-2.93|P-value:9.65E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.87|P-value:1.45E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-4.53|P-value:7.73E-7 ID:SGTC_1613|Compound:st002381|FD-Score:-3.75|P-value:3.53E-5 ID:SGTC_1736|Compound:st036774|FD-Score:4.38|P-value:1.17E-6 ID:SGTC_1770|Compound:st043884|FD-Score:4.34|P-value:1.46E-6 ID:SGTC_1781|Compound:st038725|FD-Score:-3.08|P-value:5.71E-4 ID:SGTC_2328|Compound:6201408|FD-Score:3.90|P-value:1.27E-5 ID:SGTC_2329|Compound:6138490|FD-Score:5.22|P-value:9.59E-9 ID:SGTC_2347|Compound:9049783|FD-Score:8.17|P-value:8.46E-19 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.27|P-value:2.70E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.13|P-value:3.53E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.15|P-value:4.23E-4 ID:SGTC_2432|Compound:5630864|FD-Score:4.11|P-value:4.66E-6 ID:SGTC_2455|Compound:5377712|FD-Score:-2.93|P-value:9.85E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.09|P-value:5.51E-4 ID:SGTC_2624|Compound:nerol|FD-Score:2.91|P-value:8.27E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.21|P-value:2.58E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-6.88|P-value:1.26E-13 ID:SGTC_2956|Compound:9076196|FD-Score:-2.97|P-value:8.41E-4 ID:SGTC_3287|Compound:9117173|FD-Score:3.47|P-value:8.80E-5

Top fitness defect scores for YML076C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2347 9049783 8.17 174.8 µM 8.46E-19 6 1.57E-16
2 SGTC_2329 6138490 5.22 200.0 µM 9.59E-9 8 9.09E-8
3 SGTC_602 3130-1533 4.68 38.1 µM 2.33E-7 8 1.47E-6
4 SGTC_1263 0774-1208 4.47 64.8 µM 7.21E-7 31 3.93E-6
5 SGTC_1736 st036774 4.38 51.0 µM 1.17E-6 21 5.99E-6
6 SGTC_1770 st043884 4.34 66.3 µM 1.46E-6 10 7.27E-6
7 SGTC_2432 5630864 4.11 12.2 µM 4.66E-6 18 2.00E-5
8 SGTC_798 1287-0182 4.06 476.0 µM 6.02E-6 19 2.50E-5
9 SGTC_802 4112-3352 4.03 742.0 µM 6.95E-6 24 2.83E-5
10 SGTC_2328 6201408 3.90 200.0 µM 1.27E-5 20 4.79E-5
11 SGTC_1376 2910-0861 3.87 41.3 µM 1.45E-5 19 5.37E-5
12 SGTC_1029 k015-0030 3.79 64.7 µM 2.09E-5 32 7.40E-5
13 SGTC_1203 3992-3522 3.62 103.0 µM 4.52E-5 49 1.45E-4
14 SGTC_298 1391-0729 3.58 10.0 µM 5.54E-5 calcium & mitochondrial duress 27 1.73E-4
15 SGTC_3287 9117173 3.47 37.1 µM 8.80E-5 60S ribosome export 10 2.59E-4
16 SGTC_68 0986-0284 3.42 82.8 µM 1.08E-4 96 3.10E-4
17 SGTC_237 nikkomycin 3.31 200.0 µM 1.69E-4 RSC complex & mRNA processing 35 4.59E-4
18 SGTC_2764 methyldopa 3.21 94.7 µM 2.58E-4 47 6.63E-4
19 SGTC_793 0488-0545 3.17 106.0 µM 3.04E-4 39 7.66E-4
20 SGTC_2414 st077232 3.13 92.9 µM 3.53E-4 57 8.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.245 7.65E-47 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.134 6.33E-15 YDR236C FMN1 het Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane
0.131 2.29E-14 YCR012W PGK1 het 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
0.129 5.96E-14 YDR287W INM2 hom Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
0.124 6.80E-13 YMR136W GAT2 hom Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
0.123 8.58E-13 YOL080C REX4 hom Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly
0.123 1.03E-12 YGL134W PCL10 hom Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
0.113 5.00E-11 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.111 1.28E-10 YMR125W STO1 hom Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80
0.102 3.13E-9 YDR029W_d YDR029W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.101 5.05E-9 YLR327C TMA10 hom Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress
0.096 2.75E-8 YMR104C YPK2 hom Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication
0.094 5.55E-8 YOR333C_d YOR333C_d hom Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth
0.092 8.06E-8 YGL157W ARI1 hom NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily
0.091 1.33E-7 YMR054W STV1 hom Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole