YML079W_p

Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YML079W / YML079W

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:4.13|P-value:2.58E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:3.37|P-value:4.87E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:-3.17|P-value:9.49E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-4.25|P-value:1.54E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:5.62|P-value:1.81E-8 ID:SGTC_167|Compound:3672-0051|FD-Score:4.12|P-value:2.68E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:-4.40|P-value:8.12E-6 ID:SGTC_189|Compound:3970-0742|FD-Score:-3.59|P-value:2.18E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.51|P-value:2.88E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:4.45|P-value:6.54E-6 ID:SGTC_900|Compound:1112-0045|FD-Score:-5.43|P-value:5.22E-8 ID:SGTC_948|Compound:3448-0295|FD-Score:4.24|P-value:1.65E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.76|P-value:1.13E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.17|P-value:9.68E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.66|P-value:1.71E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:4.39|P-value:8.49E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.82|P-value:9.04E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:5.95|P-value:2.82E-9 ID:SGTC_1251|Compound:0490-5699|FD-Score:5.89|P-value:4.01E-9 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.13|P-value:2.60E-5 ID:SGTC_1554|Compound:st069299|FD-Score:4.21|P-value:1.89E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.36|P-value:4.97E-4 ID:SGTC_1825|Compound:st052143|FD-Score:-3.44|P-value:3.81E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.77|P-value:1.11E-4 ID:SGTC_2425|Compound:5628681|FD-Score:-3.82|P-value:9.10E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.32|P-value:5.73E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.89|P-value:6.80E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-4.60|P-value:3.28E-6 ID:SGTC_2967|Compound:9089538|FD-Score:5.81|P-value:6.49E-9 ID:SGTC_2974|Compound:9094440|FD-Score:-3.30|P-value:6.14E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-6.36|P-value:2.33E-10 ID:SGTC_2985|Compound:9022375|FD-Score:3.28|P-value:6.47E-4 ID:SGTC_3107|Compound:9121808|FD-Score:-3.45|P-value:3.62E-4 ID:SGTC_3127|Compound:9126946|FD-Score:4.87|P-value:9.00E-7 ID:SGTC_3157|Compound:9099274|FD-Score:5.86|P-value:4.68E-9 ID:SGTC_3159|Compound:9100096|FD-Score:-3.77|P-value:1.11E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-3.65|P-value:1.72E-4 ID:SGTC_3347|Compound:9188721|FD-Score:-3.34|P-value:5.30E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:4.13|P-value:2.58E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:3.37|P-value:4.87E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:-3.17|P-value:9.49E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-4.25|P-value:1.54E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:5.62|P-value:1.81E-8 ID:SGTC_167|Compound:3672-0051|FD-Score:4.12|P-value:2.68E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:-4.40|P-value:8.12E-6 ID:SGTC_189|Compound:3970-0742|FD-Score:-3.59|P-value:2.18E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-3.51|P-value:2.88E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:4.45|P-value:6.54E-6 ID:SGTC_900|Compound:1112-0045|FD-Score:-5.43|P-value:5.22E-8 ID:SGTC_948|Compound:3448-0295|FD-Score:4.24|P-value:1.65E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.76|P-value:1.13E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.17|P-value:9.68E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.66|P-value:1.71E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:4.39|P-value:8.49E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.82|P-value:9.04E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:5.95|P-value:2.82E-9 ID:SGTC_1251|Compound:0490-5699|FD-Score:5.89|P-value:4.01E-9 ID:SGTC_1327|Compound:1436-0082|FD-Score:4.13|P-value:2.60E-5 ID:SGTC_1554|Compound:st069299|FD-Score:4.21|P-value:1.89E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.36|P-value:4.97E-4 ID:SGTC_1825|Compound:st052143|FD-Score:-3.44|P-value:3.81E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.77|P-value:1.11E-4 ID:SGTC_2425|Compound:5628681|FD-Score:-3.82|P-value:9.10E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.32|P-value:5.73E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.89|P-value:6.80E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-4.60|P-value:3.28E-6 ID:SGTC_2967|Compound:9089538|FD-Score:5.81|P-value:6.49E-9 ID:SGTC_2974|Compound:9094440|FD-Score:-3.30|P-value:6.14E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-6.36|P-value:2.33E-10 ID:SGTC_2985|Compound:9022375|FD-Score:3.28|P-value:6.47E-4 ID:SGTC_3107|Compound:9121808|FD-Score:-3.45|P-value:3.62E-4 ID:SGTC_3127|Compound:9126946|FD-Score:4.87|P-value:9.00E-7 ID:SGTC_3157|Compound:9099274|FD-Score:5.86|P-value:4.68E-9 ID:SGTC_3159|Compound:9100096|FD-Score:-3.77|P-value:1.11E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-3.65|P-value:1.72E-4 ID:SGTC_3347|Compound:9188721|FD-Score:-3.34|P-value:5.30E-4

Top fitness defect scores for YML079W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1250 0485-0349 5.95 40.2 µM 2.82E-9 5 1.35E-9
2 SGTC_1251 0490-5699 5.89 265.0 µM 4.01E-9 10 1.95E-9
3 SGTC_3157 9099274 5.86 49.5 µM 4.68E-9 3 2.28E-9
4 SGTC_2967 9089538 5.81 49.9 µM 6.49E-9 6 3.21E-9
5 SGTC_166 k072-0058 5.62 166.4 µM 1.81E-8 DNA intercalators 6 9.32E-9
6 SGTC_3127 9126946 4.87 49.5 µM 9.00E-7 ERG2 8 5.44E-7
7 SGTC_700 3453-2283 4.45 142.0 µM 6.54E-6 amide catabolism 14 4.29E-6
8 SGTC_1241 0364-0022 4.39 50.8 µM 8.49E-6 ERG2 23 5.63E-6
9 SGTC_948 3448-0295 4.24 75.3 µM 1.65E-5 21 1.12E-5
10 SGTC_1554 st069299 4.21 38.7 µM 1.89E-5 16 1.29E-5
11 SGTC_42 0133-0086 4.13 60.6 µM 2.58E-5 26 1.79E-5
12 SGTC_1327 1436-0082 4.13 2.2 µM 2.60E-5 17 1.80E-5
13 SGTC_167 3672-0051 4.12 66.2 µM 2.68E-5 38 1.86E-5
14 SGTC_2126 5251174 3.77 33.9 µM 1.11E-4 43 8.15E-5
15 SGTC_44 0929-0055 3.37 61.2 µM 4.87E-4 51 3.80E-4
16 SGTC_2985 9022375 3.28 71.4 µM 6.47E-4 RPP1 & pyrimidine depletion 54 5.10E-4
17 SGTC_1099 5-nonyloxytryptamine 3.17 2.9 µM 9.68E-4 52 7.75E-4
18 SGTC_1089 terbinafine 3.04 2.2 µM 0.00146 49 0.00119
19 SGTC_3216 9129716 3.03 49.5 µM 0.00148 RPP1 & pyrimidine depletion 74 0.00121
20 SGTC_2020 4017018 2.99 200.0 µM 0.00171 65 0.00140

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 2.16E-9 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.100 7.19E-9 YKR054C DYN1 hom Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
0.096 2.94E-8 YGR290W_d YGR290W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)
0.094 5.05E-8 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.093 8.46E-8 YPL094C SEC62 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.091 1.44E-7 YFL008W SMC1 het Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure
0.087 5.04E-7 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.086 7.31E-7 YMR042W ARG80 hom Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p
0.086 7.33E-7 YNL142W MEP2 hom Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
0.085 8.83E-7 YNL212W VID27 hom Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth
0.083 1.88E-6 YHR095W_d YHR095W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 2.03E-6 YLR282C_d YLR282C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition
0.082 2.51E-6 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
0.079 5.38E-6 YPR042C PUF2 hom Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins
0.079 5.45E-6 YPR106W ISR1 hom Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C