Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions

Zygosity: Homozygous strain
Profile for YML083C / YML083C

Click on Significant Values for Screen Details

Top fitness defect scores for YML083C deletion by condition

RankScreen IDConditionFD ScoreConc
1 SGTC_604 1000-0114 5.29 314.0 µM 1.19E-9 3 6.18E-8
2 SGTC_1919 st067113 4.22 52.3 µM 9.47E-7 TSC3-RPN4 24 1.20E-5
3 SGTC_2794 7785382 3.91 27.3 µM 5.08E-6 38 4.54E-5
4 SGTC_1908 st060353 3.77 56.5 µM 1.05E-5 RPP1 & pyrimidine depletion 43 8.05E-5
5 SGTC_2851 9015922 3.45 71.4 µM 4.95E-5 65 2.76E-4
6 SGTC_2103 5378138 3.30 10.0 µM 1.02E-4 41 4.91E-4
7 SGTC_2245 6637752 3.21 200.0 µM 1.48E-4 31 6.60E-4
8 SGTC_2919 7978188 3.20 46.4 µM 1.57E-4 51 6.91E-4
9 SGTC_808 0711-0032 3.19 135.0 µM 1.59E-4 38 7.00E-4
10 SGTC_182 3448-4371 2.99 550.5 µM 3.83E-4 59 0.00141
11 SGTC_2967 9089538 2.97 49.9 µM 4.16E-4 83 0.00150
12 SGTC_2453 5731132 2.91 22.2 µM 5.28E-4 85 0.00182
13 SGTC_2809 7964133 2.84 13.0 µM 6.82E-4 60S ribosome export 118 0.00223
14 SGTC_1309 pyrazolanthrone 2.70 13.4 µM 0.00117 77 0.00344
15 SGTC_1501 4491-0275 2.70 38.4 µM 0.00120 56 0.00351
16 SGTC_626 0214-0009 2.68 33.0 µM 0.00130 copper-dependent oxidative stress 84 0.00373
17 SGTC_2970 9090938 2.67 41.9 µM 0.00133 RNA processing & uracil transport 152 0.00380
18 SGTC_39 0986-0283 2.65 58.4 µM 0.00144 calcium & mitochondrial duress 121 0.00406
19 SGTC_1343 1487-0095 2.63 224.0 µM 0.00155 64 0.00430
20 SGTC_2487 5918373 2.61 44.0 µM 0.00164 94 0.00451

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.317 2.07E-79 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.312 1.84E-76 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.296 8.22E-69 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.276 6.62E-60 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.275 2.02E-59 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.268 3.75E-56 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.249 8.95E-49 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.249 1.86E-48 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.237 3.52E-44 YLL046C RNP1 hom Ribonucleoprotein that contains two RNA recognition motifs (RRM)
0.232 2.40E-42 YDL224C WHI4 hom Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication
0.230 1.58E-41 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.224 2.65E-39 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.218 3.15E-37 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.212 2.60E-35 YDR242W AMD2 hom Putative amidase
0.212 1.94E-35 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants