YML087C / AIM33

Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YML087C / AIM33

Click on Significant Values for Screen Details ID:SGTC_129|Compound:0088-0017|FD-Score:3.20|P-value:4.76E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:4.51|P-value:1.64E-6 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.46|P-value:1.83E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.40|P-value:2.28E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:3.24|P-value:4.19E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.85|P-value:3.53E-5 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.00|P-value:9.92E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.80|P-value:4.72E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.34|P-value:3.91E-6 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.29|P-value:3.48E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.21|P-value:4.67E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.54|P-value:1.38E-4 ID:SGTC_2101|Compound:5377231|FD-Score:-3.25|P-value:4.27E-4 ID:SGTC_2334|Compound:9017922|FD-Score:4.19|P-value:7.69E-6 ID:SGTC_2337|Compound:9009472|FD-Score:4.08|P-value:1.28E-5 ID:SGTC_2338|Compound:7999974|FD-Score:3.45|P-value:1.87E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.56|P-value:1.23E-4 ID:SGTC_2429|Compound:5902844|FD-Score:4.16|P-value:9.14E-6 ID:SGTC_2476|Compound:5806916|FD-Score:-3.70|P-value:7.26E-5 ID:SGTC_2890|Compound:9046729|FD-Score:-3.48|P-value:1.75E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-5.02|P-value:1.27E-7 ID:SGTC_2957|Compound:9076800|FD-Score:10.10|P-value:1.51E-25 ID:SGTC_2960|Compound:9079389|FD-Score:-3.02|P-value:9.58E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.55|P-value:1.25E-4 ID:SGTC_2995|Compound:9067767|FD-Score:-3.11|P-value:7.22E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.23|P-value:4.25E-4 ID:SGTC_3019|Compound:9081971|FD-Score:4.20|P-value:7.55E-6 ID:SGTC_3062|Compound:9077494|FD-Score:3.16|P-value:5.67E-4 ID:SGTC_3096|Compound:9117468|FD-Score:-3.69|P-value:7.57E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:3.20|P-value:4.76E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:4.51|P-value:1.64E-6 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.46|P-value:1.83E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.40|P-value:2.28E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:3.24|P-value:4.19E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.85|P-value:3.53E-5 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.00|P-value:9.92E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.80|P-value:4.72E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.34|P-value:3.91E-6 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.29|P-value:3.48E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.21|P-value:4.67E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.54|P-value:1.38E-4 ID:SGTC_2101|Compound:5377231|FD-Score:-3.25|P-value:4.27E-4 ID:SGTC_2334|Compound:9017922|FD-Score:4.19|P-value:7.69E-6 ID:SGTC_2337|Compound:9009472|FD-Score:4.08|P-value:1.28E-5 ID:SGTC_2338|Compound:7999974|FD-Score:3.45|P-value:1.87E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.56|P-value:1.23E-4 ID:SGTC_2429|Compound:5902844|FD-Score:4.16|P-value:9.14E-6 ID:SGTC_2476|Compound:5806916|FD-Score:-3.70|P-value:7.26E-5 ID:SGTC_2890|Compound:9046729|FD-Score:-3.48|P-value:1.75E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-5.02|P-value:1.27E-7 ID:SGTC_2957|Compound:9076800|FD-Score:10.10|P-value:1.51E-25 ID:SGTC_2960|Compound:9079389|FD-Score:-3.02|P-value:9.58E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.55|P-value:1.25E-4 ID:SGTC_2995|Compound:9067767|FD-Score:-3.11|P-value:7.22E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.23|P-value:4.25E-4 ID:SGTC_3019|Compound:9081971|FD-Score:4.20|P-value:7.55E-6 ID:SGTC_3062|Compound:9077494|FD-Score:3.16|P-value:5.67E-4 ID:SGTC_3096|Compound:9117468|FD-Score:-3.69|P-value:7.57E-5

Top fitness defect scores for YML087C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2957 9076800 10.10 11.5 µM 1.51E-25 1 3.31E-24
2 SGTC_132 0417-1715 4.51 25.8 µM 1.64E-6 RPP1 & pyrimidine depletion 13 3.19E-6
3 SGTC_1425 4048-4433 4.34 7.3 µM 3.91E-6 copper-dependent oxidative stress 31 7.24E-6
4 SGTC_3019 9081971 4.20 49.5 µM 7.55E-6 13 1.35E-5
5 SGTC_2334 9017922 4.19 200.0 µM 7.69E-6 19 1.37E-5
6 SGTC_2429 5902844 4.16 64.4 µM 9.14E-6 18 1.62E-5
7 SGTC_2337 9009472 4.08 200.0 µM 1.28E-5 29 2.23E-5
8 SGTC_1262 0737-0114 3.85 49.6 µM 3.53E-5 20 5.79E-5
9 SGTC_2419 paclitaxel 3.56 166.5 µM 1.23E-4 62 1.89E-4
10 SGTC_2962 9082311 3.55 13.2 µM 1.25E-4 33 1.91E-4
11 SGTC_248 streptozotocin 3.46 5.2 mM 1.83E-4 DNA damage response 33 2.75E-4
12 SGTC_2338 7999974 3.45 200.0 µM 1.87E-4 38 2.81E-4
13 SGTC_385 1494-0393 3.40 12.4 µM 2.28E-4 47 3.39E-4
14 SGTC_1431 4049-0260 3.29 9.1 µM 3.48E-4 17 5.05E-4
15 SGTC_845 0330-0138 3.24 4.5 µM 4.19E-4 40 6.02E-4
16 SGTC_3006 9075424 3.23 71.4 µM 4.25E-4 34 6.10E-4
17 SGTC_1435 4092-0789 3.21 56.7 µM 4.67E-4 plasma membrane duress 36 6.67E-4
18 SGTC_129 0088-0017 3.20 176.6 µM 4.76E-4 101 6.79E-4
19 SGTC_3062 9077494 3.16 49.5 µM 5.67E-4 mitochondrial response to ROS 67 8.02E-4
20 SGTC_1412 3909-8563 3.00 178.0 µM 9.92E-4 44 0.00136

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.181 4.13E-26 YGR050C_p YGR050C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.138 8.71E-16 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.134 5.28E-15 YGL138C_p YGL138C_p hom Putative protein of unknown function; has no significant sequence similarity to any known protein
0.132 1.41E-14 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.130 3.76E-14 YDL039C PRM7 hom Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements
0.125 3.29E-13 YOR255W OSW1 hom Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p
0.125 3.80E-13 YJR133W XPT1 hom Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine
0.121 1.83E-12 YLR352W_p YLR352W_p hom Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene
0.111 9.85E-11 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.110 2.00E-10 YHR191C CTF8 hom Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion
0.108 3.36E-10 YNR014W_p YNR014W_p hom Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication
0.107 5.51E-10 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.104 1.36E-9 YDL130W-A STF1 hom Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress
0.102 3.43E-9 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.100 5.66E-9 YGL034C_d YGL034C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data