YML100W-A_p

Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

Zygosity: Homozygous strain
fixedexpanded
Profile for YML100W-A / YML100W-A

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:2.94|P-value:5.00E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.17|P-value:1.98E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.10|P-value:3.76E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.72|P-value:1.70E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:3.51|P-value:4.54E-5 ID:SGTC_938|Compound:3126-1755|FD-Score:3.05|P-value:3.30E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.38|P-value:7.93E-5 ID:SGTC_1449|Compound:4112-4002|FD-Score:2.87|P-value:6.61E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.59|P-value:3.14E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.48|P-value:7.51E-5 ID:SGTC_1471|Compound:k673-0312|FD-Score:-3.49|P-value:7.10E-5 ID:SGTC_1644|Compound:st010134|FD-Score:2.83|P-value:7.59E-4 ID:SGTC_2096|Compound:5468907|FD-Score:3.12|P-value:2.44E-4 ID:SGTC_2134|Compound:5324836|FD-Score:-3.11|P-value:3.63E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:2.77|P-value:9.66E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.10|P-value:2.70E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-4.53|P-value:3.85E-7 ID:SGTC_73|Compound:0327-0325|FD-Score:2.94|P-value:5.00E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.17|P-value:1.98E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.10|P-value:3.76E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.72|P-value:1.70E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:3.51|P-value:4.54E-5 ID:SGTC_938|Compound:3126-1755|FD-Score:3.05|P-value:3.30E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.38|P-value:7.93E-5 ID:SGTC_1449|Compound:4112-4002|FD-Score:2.87|P-value:6.61E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.59|P-value:3.14E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.48|P-value:7.51E-5 ID:SGTC_1471|Compound:k673-0312|FD-Score:-3.49|P-value:7.10E-5 ID:SGTC_1644|Compound:st010134|FD-Score:2.83|P-value:7.59E-4 ID:SGTC_2096|Compound:5468907|FD-Score:3.12|P-value:2.44E-4 ID:SGTC_2134|Compound:5324836|FD-Score:-3.11|P-value:3.63E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:2.77|P-value:9.66E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.10|P-value:2.70E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-4.53|P-value:3.85E-7

Top fitness defect scores for YML100W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_803 4488-1585 3.72 147.0 µM 1.70E-5 17 1.00E-4
2 SGTC_1456 k015-0012 3.59 13.0 µM 3.14E-5 45 1.66E-4
3 SGTC_902 1120-0002 3.51 2.1 µM 4.54E-5 azole & statin 60 2.25E-4
4 SGTC_1138 3761-0006 3.38 1.0 µM 7.93E-5 16 3.56E-4
5 SGTC_503 tyrphostin 8 3.17 294.0 µM 1.98E-4 TSC3-RPN4 62 7.57E-4
6 SGTC_2096 5468907 3.12 200.0 µM 2.44E-4 27 9.00E-4
7 SGTC_2757 clomiphene 3.10 4.2 µM 2.70E-4 fatty acid desaturase (OLE1) 85 9.77E-4
8 SGTC_938 3126-1755 3.05 342.0 µM 3.30E-4 39 0.00115
9 SGTC_73 0327-0325 2.94 16.2 µM 5.00E-4 DNA damage response 124 0.00162
10 SGTC_1449 4112-4002 2.87 201.0 µM 6.61E-4 RPP1 & pyrimidine depletion 54 0.00205
11 SGTC_1644 st010134 2.83 20.9 µM 7.59E-4 mitochondrial processes 44 0.00229
12 SGTC_2610 ononetin 2.77 44.2 µM 9.66E-4 123 0.00280
13 SGTC_1421 4029-0249 2.76 71.4 µM 0.00102 70 0.00293
14 SGTC_80 0159-0065 2.72 512.2 µM 0.00116 29 0.00326
15 SGTC_2375 9072683 2.72 200.0 µM 0.00118 mitochondrial processes 101 0.00330
16 SGTC_2815 7968870 2.68 71.4 µM 0.00135 107 0.00370
17 SGTC_2595 hexamethylquercetagetin 2.65 100.0 µM 0.00152 100 0.00406
18 SGTC_1408 3909-7976 2.57 48.8 µM 0.00199 Golgi 122 0.00508
19 SGTC_57 miconazole 2.56 162.5 nM 0.00206 ergosterol depletion effects on membrane 109 0.00523
20 SGTC_2829 7992743 2.51 58.4 µM 0.00245 147 0.00603

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 4.28E-19 YLR004C THI73 hom Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
0.150 2.66E-18 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.140 3.71E-16 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.134 6.93E-15 YHR141C RPL42B hom Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication
0.115 2.47E-11 YDL108W KIN28 het Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
0.113 5.01E-11 YLR082C SRL2 hom Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation
0.110 1.66E-10 YLR307W CDA1 hom Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
0.106 7.66E-10 YGL257C MNT2 hom Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans
0.103 1.99E-9 YLL037W_d YLL037W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor
0.103 2.04E-9 YKR002W PAP1 het Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
0.102 3.39E-9 YGR138C TPO2 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication
0.102 3.32E-9 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.099 9.06E-9 YLR211C_p YLR211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron
0.094 5.55E-8 YJR135W-A TIM8 hom Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome
0.092 8.33E-8 YCR067C SED4 hom Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p