YML101C / CUE4

Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YML101C / CUE4

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.07|P-value:1.29E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:5.57|P-value:3.01E-11 ID:SGTC_41|Compound:0478-0632|FD-Score:3.97|P-value:1.38E-6 ID:SGTC_370|Compound:0180-0345|FD-Score:-2.82|P-value:8.58E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:-3.15|P-value:2.10E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:5.02|P-value:1.76E-9 ID:SGTC_646|Compound:4092-0839|FD-Score:3.54|P-value:1.37E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:2.94|P-value:2.33E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-2.80|P-value:9.29E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.10|P-value:2.68E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.85|P-value:7.67E-6 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.17|P-value:8.20E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.78|P-value:9.84E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:2.62|P-value:8.53E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.23|P-value:1.48E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:2.67|P-value:7.02E-4 ID:SGTC_1854|Compound:st056233|FD-Score:2.74|P-value:5.39E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-3.68|P-value:1.76E-5 ID:SGTC_2101|Compound:5377231|FD-Score:2.87|P-value:3.09E-4 ID:SGTC_2103|Compound:5378138|FD-Score:4.26|P-value:2.45E-7 ID:SGTC_2125|Compound:5246583|FD-Score:2.76|P-value:4.90E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.77|P-value:4.67E-4 ID:SGTC_2451|Compound:5856223|FD-Score:6.68|P-value:2.75E-15 ID:SGTC_2850|Compound:9015429|FD-Score:-3.10|P-value:2.64E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.17|P-value:8.19E-5 ID:SGTC_2919|Compound:7978188|FD-Score:3.06|P-value:1.33E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.83|P-value:2.85E-6 ID:SGTC_2970|Compound:9090938|FD-Score:2.75|P-value:5.06E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.05|P-value:3.25E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.18|P-value:1.90E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.40|P-value:2.77E-5 ID:SGTC_3190|Compound:9110366|FD-Score:2.59|P-value:9.63E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.43|P-value:6.06E-5 ID:SGTC_3195|Compound:9113082|FD-Score:2.63|P-value:8.22E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-3.03|P-value:3.62E-4 ID:SGTC_3345|Compound:9148410|FD-Score:2.63|P-value:8.15E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.07|P-value:1.29E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:5.57|P-value:3.01E-11 ID:SGTC_41|Compound:0478-0632|FD-Score:3.97|P-value:1.38E-6 ID:SGTC_370|Compound:0180-0345|FD-Score:-2.82|P-value:8.58E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:-3.15|P-value:2.10E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:5.02|P-value:1.76E-9 ID:SGTC_646|Compound:4092-0839|FD-Score:3.54|P-value:1.37E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:2.94|P-value:2.33E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-2.80|P-value:9.29E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.10|P-value:2.68E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.85|P-value:7.67E-6 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.17|P-value:8.20E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.78|P-value:9.84E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:2.62|P-value:8.53E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.23|P-value:1.48E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:2.67|P-value:7.02E-4 ID:SGTC_1854|Compound:st056233|FD-Score:2.74|P-value:5.39E-4 ID:SGTC_1857|Compound:st056007|FD-Score:-3.68|P-value:1.76E-5 ID:SGTC_2101|Compound:5377231|FD-Score:2.87|P-value:3.09E-4 ID:SGTC_2103|Compound:5378138|FD-Score:4.26|P-value:2.45E-7 ID:SGTC_2125|Compound:5246583|FD-Score:2.76|P-value:4.90E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:2.77|P-value:4.67E-4 ID:SGTC_2451|Compound:5856223|FD-Score:6.68|P-value:2.75E-15 ID:SGTC_2850|Compound:9015429|FD-Score:-3.10|P-value:2.64E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.17|P-value:8.19E-5 ID:SGTC_2919|Compound:7978188|FD-Score:3.06|P-value:1.33E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.83|P-value:2.85E-6 ID:SGTC_2970|Compound:9090938|FD-Score:2.75|P-value:5.06E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.05|P-value:3.25E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.18|P-value:1.90E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.40|P-value:2.77E-5 ID:SGTC_3190|Compound:9110366|FD-Score:2.59|P-value:9.63E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.43|P-value:6.06E-5 ID:SGTC_3195|Compound:9113082|FD-Score:2.63|P-value:8.22E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-3.03|P-value:3.62E-4 ID:SGTC_3345|Compound:9148410|FD-Score:2.63|P-value:8.15E-4

Top fitness defect scores for YML101C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2451 5856223 6.68 45.7 µM 2.75E-15 2 1.23E-11
2 SGTC_39 0986-0283 5.57 58.4 µM 3.01E-11 calcium & mitochondrial duress 9 1.24E-8
3 SGTC_611 3453-1652 5.02 23.7 µM 1.76E-9 8 2.57E-7
4 SGTC_2103 5378138 4.26 10.0 µM 2.45E-7 8 1.01E-5
5 SGTC_41 0478-0632 3.97 82.6 µM 1.38E-6 28 3.65E-5
6 SGTC_2967 9089538 3.83 49.9 µM 2.85E-6 37 6.28E-5
7 SGTC_646 4092-0839 3.54 27.3 µM 1.37E-5 plasma membrane duress 37 2.02E-4
8 SGTC_3012 9080433 3.40 71.4 µM 2.77E-5 24 3.41E-4
9 SGTC_2918 7977171 3.17 22.1 µM 8.19E-5 50 7.63E-4
10 SGTC_1246 0422-0085 3.17 105.0 µM 8.20E-5 69 7.64E-4
11 SGTC_38 0929-0051 3.07 58.3 µM 1.29E-4 69 0.00107
12 SGTC_2919 7978188 3.06 46.4 µM 1.33E-4 61 0.00109
13 SGTC_650 1328-0195 2.94 38.0 µM 2.33E-4 65 0.00166
14 SGTC_2101 5377231 2.87 179.2 µM 3.09E-4 38 0.00205
15 SGTC_2130 NSC 7 2.77 2.5 µM 4.67E-4 copper-dependent oxidative stress 118 0.00279
16 SGTC_2125 5246583 2.76 200.0 µM 4.90E-4 tubulin folding & SWR complex 119 0.00289
17 SGTC_2970 9090938 2.75 41.9 µM 5.06E-4 RNA processing & uracil transport 138 0.00297
18 SGTC_1854 st056233 2.74 32.9 µM 5.39E-4 amide catabolism 76 0.00311
19 SGTC_1509 1326-1131 2.67 80.0 µM 7.02E-4 63 0.00378
20 SGTC_3345 9148410 2.63 3.6 µM 8.15E-4 54 0.00423

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.245 3.21E-47 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.238 2.91E-44 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.224 2.16E-39 YLL038C ENT4 hom Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome
0.223 7.43E-39 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.179 1.23E-25 YFR054C_d YFR054C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.175 2.21E-24 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.167 2.05E-22 YNL011C_p YNL011C_p hom Putative protein of unknown function; YNL011C is not an essential gene
0.156 9.12E-20 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.149 3.77E-18 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.149 3.96E-18 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.146 2.09E-17 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.145 3.27E-17 YGR117C_p YGR117C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.141 2.03E-16 YIL135C VHS2 hom Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
0.139 7.40E-16 YPL063W TIM50 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel
0.135 3.99E-15 YIL173W VTH1 hom Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting