YML101C-A_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YML101C-A / YML101C-A

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:7.48|P-value:5.49E-16 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:14.50|P-value:9.35E-55 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.18|P-value:2.90E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:4.53|P-value:6.39E-7 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.19|P-value:2.78E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.19|P-value:2.73E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-2.93|P-value:7.44E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.22|P-value:2.93E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.16|P-value:3.06E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.02|P-value:6.50E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:-3.41|P-value:1.14E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.18|P-value:2.86E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.39|P-value:1.23E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:-3.35|P-value:1.44E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.03|P-value:5.08E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.49|P-value:9.84E-5 ID:SGTC_1984|Compound:st072354|FD-Score:4.19|P-value:3.89E-6 ID:SGTC_2098|Compound:5376439|FD-Score:3.98|P-value:1.05E-5 ID:SGTC_2107|Compound:5363541|FD-Score:3.23|P-value:2.84E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.45|P-value:1.17E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.79|P-value:1.74E-13 ID:SGTC_2584|Compound:androsterone|FD-Score:3.23|P-value:2.86E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.01|P-value:6.58E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.17|P-value:2.97E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.67|P-value:4.51E-5 ID:SGTC_2987|Compound:9018338|FD-Score:3.54|P-value:7.95E-5 ID:SGTC_3141|Compound:9094609|FD-Score:3.47|P-value:1.06E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.10|P-value:4.77E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.12|P-value:4.48E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.48|P-value:5.49E-16 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:14.50|P-value:9.35E-55 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.18|P-value:2.90E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:4.53|P-value:6.39E-7 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.19|P-value:2.78E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.19|P-value:2.73E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-2.93|P-value:7.44E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.22|P-value:2.93E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.16|P-value:3.06E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.02|P-value:6.50E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:-3.41|P-value:1.14E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.18|P-value:2.86E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.39|P-value:1.23E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:-3.35|P-value:1.44E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.03|P-value:5.08E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.49|P-value:9.84E-5 ID:SGTC_1984|Compound:st072354|FD-Score:4.19|P-value:3.89E-6 ID:SGTC_2098|Compound:5376439|FD-Score:3.98|P-value:1.05E-5 ID:SGTC_2107|Compound:5363541|FD-Score:3.23|P-value:2.84E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.45|P-value:1.17E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.79|P-value:1.74E-13 ID:SGTC_2584|Compound:androsterone|FD-Score:3.23|P-value:2.86E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.01|P-value:6.58E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.17|P-value:2.97E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.67|P-value:4.51E-5 ID:SGTC_2987|Compound:9018338|FD-Score:3.54|P-value:7.95E-5 ID:SGTC_3141|Compound:9094609|FD-Score:3.47|P-value:1.06E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.10|P-value:4.77E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.12|P-value:4.48E-4

Top fitness defect scores for YML101C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_453 enantio-paf c16 14.50 10.0 µM 9.35E-55 2 7.33E-48
2 SGTC_58 0957-0393 7.48 9.0 µM 5.49E-16 cell wall 144 3.60E-14
3 SGTC_2582 agaric acid 6.79 100.0 µM 1.74E-13 redox potentiating 135 5.43E-12
4 SGTC_543 3844-1095 4.53 191.0 µM 6.39E-7 ERG2 38 2.92E-6
5 SGTC_1984 st072354 4.19 53.1 µM 3.89E-6 13 1.42E-5
6 SGTC_2098 5376439 3.98 882.5 nM 1.05E-5 11 3.40E-5
7 SGTC_2978 9011784 3.67 43.0 µM 4.51E-5 41 1.22E-4
8 SGTC_2987 9018338 3.54 71.4 µM 7.95E-5 RPP1 & pyrimidine depletion 35 2.01E-4
9 SGTC_1476 4112-3294 3.49 3.3 µM 9.84E-5 60S ribosome export 33 2.42E-4
10 SGTC_3141 9094609 3.47 49.5 µM 1.06E-4 iron homeostasis 50 2.58E-4
11 SGTC_2419 paclitaxel 3.45 166.5 µM 1.17E-4 72 2.81E-4
12 SGTC_2107 5363541 3.23 170.2 µM 2.84E-4 21 6.14E-4
13 SGTC_2584 androsterone 3.23 48.7 µM 2.86E-4 cell wall 185 6.19E-4
14 SGTC_852 0418-0143 3.22 439.0 µM 2.93E-4 calcium & mitochondrial duress 114 6.32E-4
15 SGTC_3302 9125395 3.12 16.4 µM 4.48E-4 39 9.18E-4
16 SGTC_3299 9121982 3.10 43.1 µM 4.77E-4 67 9.70E-4
17 SGTC_930 2810-3379 3.02 265.0 µM 6.50E-4 46 0.00127
18 SGTC_2768 sulfasalazine 3.01 50.2 µM 6.58E-4 57 0.00129
19 SGTC_2537 larixol 2.89 68.9 µM 0.00103 87 0.00190
20 SGTC_2940 9060638 2.89 45.9 µM 0.00105 amide catabolism 89 0.00195

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.367 8.70E-108 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.347 2.17E-95 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.338 2.60E-90 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.331 1.65E-86 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.318 1.30E-79 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.302 9.85E-72 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.284 2.26E-63 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.284 4.85E-63 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.275 4.40E-59 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.270 3.81E-57 YBL005W PDR3 hom Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.253 2.42E-50 YER072W VTC1 hom Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress
0.241 1.74E-45 YLR298C YHC1 het Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
0.241 2.29E-45 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.241 2.12E-45 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.240 2.54E-45 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication