YML104C / MDM1

Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)

Zygosity: Homozygous strain
fixedexpanded
Profile for YML104C / MDM1

Click on Significant Values for Screen Details ID:SGTC_281|Compound:1672-3440|FD-Score:2.81|P-value:4.04E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.17|P-value:9.09E-5 ID:SGTC_334|Compound:1502-1024|FD-Score:2.73|P-value:5.55E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:3.15|P-value:8.43E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:-2.64|P-value:9.35E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:2.72|P-value:5.89E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-2.82|P-value:4.34E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:-2.65|P-value:8.75E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:2.74|P-value:5.37E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.67|P-value:6.13E-6 ID:SGTC_1451|Compound:4152-0210|FD-Score:2.85|P-value:3.35E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.11|P-value:1.05E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-2.86|P-value:3.62E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.27|P-value:5.60E-5 ID:SGTC_1715|Compound:st032160|FD-Score:3.07|P-value:1.26E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-4.87|P-value:4.13E-9 ID:SGTC_1723|Compound:st034307|FD-Score:-3.47|P-value:2.06E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-2.73|P-value:6.42E-4 ID:SGTC_1751|Compound:st044839|FD-Score:3.43|P-value:2.20E-5 ID:SGTC_1760|Compound:st045453|FD-Score:3.68|P-value:5.62E-6 ID:SGTC_1963|Compound:st076565|FD-Score:-3.46|P-value:2.18E-5 ID:SGTC_1974|Compound:st069448|FD-Score:3.58|P-value:1.01E-5 ID:SGTC_1976|Compound:st070609|FD-Score:4.18|P-value:3.17E-7 ID:SGTC_2111|Compound:5486399|FD-Score:-5.27|P-value:2.22E-10 ID:SGTC_2113|Compound:5491891|FD-Score:-5.87|P-value:1.87E-12 ID:SGTC_2122|Compound:5258151|FD-Score:-3.73|P-value:5.18E-6 ID:SGTC_2238|Compound:6671620|FD-Score:-2.76|P-value:5.62E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.91|P-value:1.87E-6 ID:SGTC_2309|Compound:7664088|FD-Score:3.69|P-value:5.55E-6 ID:SGTC_2316|Compound:5844804|FD-Score:3.92|P-value:1.46E-6 ID:SGTC_2319|Compound:6033012|FD-Score:-3.86|P-value:2.59E-6 ID:SGTC_2325|Compound:6158266|FD-Score:-3.40|P-value:2.93E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-2.95|P-value:2.46E-4 ID:SGTC_2814|Compound:7977482|FD-Score:4.06|P-value:6.39E-7 ID:SGTC_2828|Compound:7998861|FD-Score:3.13|P-value:9.44E-5 ID:SGTC_3314|Compound:9135860|FD-Score:3.14|P-value:8.93E-5 ID:SGTC_3328|Compound:9140624|FD-Score:3.73|P-value:4.41E-6 ID:SGTC_3331|Compound:9141060|FD-Score:2.95|P-value:2.12E-4 ID:SGTC_281|Compound:1672-3440|FD-Score:2.81|P-value:4.04E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.17|P-value:9.09E-5 ID:SGTC_334|Compound:1502-1024|FD-Score:2.73|P-value:5.55E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:3.15|P-value:8.43E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:-2.64|P-value:9.35E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:2.72|P-value:5.89E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-2.82|P-value:4.34E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:-2.65|P-value:8.75E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:2.74|P-value:5.37E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.67|P-value:6.13E-6 ID:SGTC_1451|Compound:4152-0210|FD-Score:2.85|P-value:3.35E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.11|P-value:1.05E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-2.86|P-value:3.62E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.27|P-value:5.60E-5 ID:SGTC_1715|Compound:st032160|FD-Score:3.07|P-value:1.26E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-4.87|P-value:4.13E-9 ID:SGTC_1723|Compound:st034307|FD-Score:-3.47|P-value:2.06E-5 ID:SGTC_1724|Compound:st037281|FD-Score:-2.73|P-value:6.42E-4 ID:SGTC_1751|Compound:st044839|FD-Score:3.43|P-value:2.20E-5 ID:SGTC_1760|Compound:st045453|FD-Score:3.68|P-value:5.62E-6 ID:SGTC_1963|Compound:st076565|FD-Score:-3.46|P-value:2.18E-5 ID:SGTC_1974|Compound:st069448|FD-Score:3.58|P-value:1.01E-5 ID:SGTC_1976|Compound:st070609|FD-Score:4.18|P-value:3.17E-7 ID:SGTC_2111|Compound:5486399|FD-Score:-5.27|P-value:2.22E-10 ID:SGTC_2113|Compound:5491891|FD-Score:-5.87|P-value:1.87E-12 ID:SGTC_2122|Compound:5258151|FD-Score:-3.73|P-value:5.18E-6 ID:SGTC_2238|Compound:6671620|FD-Score:-2.76|P-value:5.62E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.91|P-value:1.87E-6 ID:SGTC_2309|Compound:7664088|FD-Score:3.69|P-value:5.55E-6 ID:SGTC_2316|Compound:5844804|FD-Score:3.92|P-value:1.46E-6 ID:SGTC_2319|Compound:6033012|FD-Score:-3.86|P-value:2.59E-6 ID:SGTC_2325|Compound:6158266|FD-Score:-3.40|P-value:2.93E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-2.95|P-value:2.46E-4 ID:SGTC_2814|Compound:7977482|FD-Score:4.06|P-value:6.39E-7 ID:SGTC_2828|Compound:7998861|FD-Score:3.13|P-value:9.44E-5 ID:SGTC_3314|Compound:9135860|FD-Score:3.14|P-value:8.93E-5 ID:SGTC_3328|Compound:9140624|FD-Score:3.73|P-value:4.41E-6 ID:SGTC_3331|Compound:9141060|FD-Score:2.95|P-value:2.12E-4

Top fitness defect scores for YML104C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1976 st070609 4.18 63.5 µM 3.17E-7 8 1.45E-5
2 SGTC_2814 7977482 4.06 43.0 µM 6.39E-7 46 2.40E-5
3 SGTC_2316 5844804 3.92 197.4 µM 1.46E-6 32 4.34E-5
4 SGTC_3328 9140624 3.73 29.0 µM 4.41E-6 25 9.62E-5
5 SGTC_2309 7664088 3.69 163.9 µM 5.55E-6 46 1.13E-4
6 SGTC_1760 st045453 3.68 10.4 µM 5.62E-6 NEO1-PIK1 156 1.15E-4
7 SGTC_1376 2910-0861 3.67 41.3 µM 6.13E-6 27 1.22E-4
8 SGTC_1974 st069448 3.58 26.9 µM 1.01E-5 34 1.74E-4
9 SGTC_1751 st044839 3.43 27.2 µM 2.20E-5 Golgi 19 3.06E-4
10 SGTC_556 4058-0063 3.15 51.5 µM 8.43E-5 53 8.05E-4
11 SGTC_3314 9135860 3.14 59.4 µM 8.93E-5 49 8.39E-4
12 SGTC_2828 7998861 3.13 71.4 µM 9.44E-5 42 8.74E-4
13 SGTC_1503 4585-0012 3.11 61.3 µM 1.05E-4 46 9.47E-4
14 SGTC_1715 st032160 3.07 10.2 µM 1.26E-4 82 0.00107
15 SGTC_3331 9141060 2.95 2.0 µM 2.12E-4 cell wall 72 0.00157
16 SGTC_1451 4152-0210 2.85 104.0 µM 3.35E-4 90 0.00218
17 SGTC_281 1672-3440 2.81 14.9 µM 4.04E-4 Golgi 40 0.00250
18 SGTC_1128 3448-9350 2.74 235.0 µM 5.37E-4 86 0.00308
19 SGTC_334 1502-1024 2.73 68.5 µM 5.55E-4 76 0.00315
20 SGTC_940 3232-1287 2.72 54.8 µM 5.89E-4 NEO1 107 0.00329

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.146 1.59E-17 YHL012W_p YHL012W_p hom Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication
0.141 2.36E-16 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.120 3.62E-12 YOR126C IAH1 hom Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing
0.120 3.76E-12 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.119 5.37E-12 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.116 1.41E-11 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.112 8.84E-11 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.109 2.50E-10 YGL139W FLC3 hom Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER
0.107 5.58E-10 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.100 7.30E-9 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.095 3.08E-8 YPR011C_p YPR011C_p hom Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.095 3.35E-8 YGR122C-A_d YGR122C-A_d hom Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W
0.093 6.46E-8 YBL018C POP8 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.093 6.88E-8 YJL200C ACO2 hom Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
0.089 2.55E-7 YMR162C DNF3 hom Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase