YML119W_p

Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YML119W / YML119W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.25|P-value:4.15E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:5.37|P-value:1.56E-8 ID:SGTC_369|Compound:0957-0393|FD-Score:4.53|P-value:1.52E-6 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.01|P-value:8.69E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.13|P-value:6.35E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:5.29|P-value:2.50E-8 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:3.27|P-value:3.87E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:7.63|P-value:1.67E-15 ID:SGTC_613|Compound:3914-0030|FD-Score:-5.08|P-value:6.64E-8 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.21|P-value:4.28E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.83|P-value:3.10E-7 ID:SGTC_1038|Compound:k292-0204|FD-Score:-2.98|P-value:9.63E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.23|P-value:4.36E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.10|P-value:7.02E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.12|P-value:5.90E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.04|P-value:8.66E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.34|P-value:2.55E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.06|P-value:7.19E-4 ID:SGTC_1695|Compound:st026914|FD-Score:-3.47|P-value:1.56E-4 ID:SGTC_1715|Compound:st032160|FD-Score:4.43|P-value:2.46E-6 ID:SGTC_1716|Compound:st033144|FD-Score:3.84|P-value:3.81E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-3.28|P-value:3.22E-4 ID:SGTC_1931|Compound:st074438|FD-Score:-3.31|P-value:2.86E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.40|P-value:2.05E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.26|P-value:5.69E-6 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.44|P-value:1.95E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.34|P-value:2.88E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.64|P-value:9.00E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:7.36|P-value:1.55E-14 ID:SGTC_2593|Compound:nobiletin|FD-Score:-4.49|P-value:1.55E-6 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.83|P-value:3.41E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.02|P-value:9.51E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.16|P-value:5.05E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.29|P-value:3.14E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.04|P-value:7.89E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.34|P-value:2.57E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.24|P-value:3.72E-4 ID:SGTC_2958|Compound:9077254|FD-Score:4.55|P-value:1.35E-6 ID:SGTC_2961|Compound:9083290|FD-Score:-3.04|P-value:7.88E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-5.96|P-value:3.12E-10 ID:SGTC_3211|Compound:9128781|FD-Score:-4.87|P-value:2.17E-7 ID:SGTC_3311|Compound:9131146|FD-Score:3.69|P-value:7.31E-5 ID:SGTC_3321|Compound:9137793|FD-Score:3.28|P-value:3.65E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.25|P-value:4.15E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:5.37|P-value:1.56E-8 ID:SGTC_369|Compound:0957-0393|FD-Score:4.53|P-value:1.52E-6 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.01|P-value:8.69E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.13|P-value:6.35E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:5.29|P-value:2.50E-8 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:3.27|P-value:3.87E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:7.63|P-value:1.67E-15 ID:SGTC_613|Compound:3914-0030|FD-Score:-5.08|P-value:6.64E-8 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.21|P-value:4.28E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.83|P-value:3.10E-7 ID:SGTC_1038|Compound:k292-0204|FD-Score:-2.98|P-value:9.63E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.23|P-value:4.36E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:3.10|P-value:7.02E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.12|P-value:5.90E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.04|P-value:8.66E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.34|P-value:2.55E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.06|P-value:7.19E-4 ID:SGTC_1695|Compound:st026914|FD-Score:-3.47|P-value:1.56E-4 ID:SGTC_1715|Compound:st032160|FD-Score:4.43|P-value:2.46E-6 ID:SGTC_1716|Compound:st033144|FD-Score:3.84|P-value:3.81E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-3.28|P-value:3.22E-4 ID:SGTC_1931|Compound:st074438|FD-Score:-3.31|P-value:2.86E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.40|P-value:2.05E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.26|P-value:5.69E-6 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.44|P-value:1.95E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.34|P-value:2.88E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.64|P-value:9.00E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:7.36|P-value:1.55E-14 ID:SGTC_2593|Compound:nobiletin|FD-Score:-4.49|P-value:1.55E-6 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.83|P-value:3.41E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.02|P-value:9.51E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.16|P-value:5.05E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.29|P-value:3.14E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.04|P-value:7.89E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.34|P-value:2.57E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.24|P-value:3.72E-4 ID:SGTC_2958|Compound:9077254|FD-Score:4.55|P-value:1.35E-6 ID:SGTC_2961|Compound:9083290|FD-Score:-3.04|P-value:7.88E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-5.96|P-value:3.12E-10 ID:SGTC_3211|Compound:9128781|FD-Score:-4.87|P-value:2.17E-7 ID:SGTC_3311|Compound:9131146|FD-Score:3.69|P-value:7.31E-5 ID:SGTC_3321|Compound:9137793|FD-Score:3.28|P-value:3.65E-4

Top fitness defect scores for YML119W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_514 4466-0038 7.63 2.6 nM 1.67E-15 cell wall 47 1.17E-14
2 SGTC_2584 androsterone 7.36 48.7 µM 1.55E-14 cell wall 29 9.39E-14
3 SGTC_360 0957-0399 5.37 1.0 µM 1.56E-8 cell wall 18 4.01E-8
4 SGTC_383 2324-0395 5.29 7.4 µM 2.50E-8 azole & statin 19 6.28E-8
5 SGTC_916 4466-0038 4.83 42.0 nM 3.10E-7 cell wall 41 6.66E-7
6 SGTC_2958 9077254 4.55 16.7 µM 1.35E-6 16 2.66E-6
7 SGTC_369 0957-0393 4.53 4.5 µM 1.52E-6 cell wall signaling 12 2.96E-6
8 SGTC_1715 st032160 4.43 10.2 µM 2.46E-6 33 4.67E-6
9 SGTC_2130 NSC 7 4.26 2.5 µM 5.69E-6 copper-dependent oxidative stress 17 1.03E-5
10 SGTC_1716 st033144 3.84 30.6 µM 3.81E-5 25 6.15E-5
11 SGTC_3311 9131146 3.69 2.9 µM 7.31E-5 cell wall 130 1.14E-4
12 SGTC_2567 aureobasidin a 3.64 60.0 nM 9.00E-5 106 1.38E-4
13 SGTC_2131 toluylene red 3.44 5.3 µM 1.95E-4 60S ribosome export 43 2.86E-4
14 SGTC_2253 7938677 3.34 135.8 µM 2.88E-4 30 4.13E-4
15 SGTC_3321 9137793 3.28 26.8 µM 3.65E-4 cell wall 103 5.16E-4
16 SGTC_477 mead ethanolamide 3.27 10.0 µM 3.87E-4 8 5.46E-4
17 SGTC_58 0957-0393 3.25 9.0 µM 4.15E-4 cell wall 457 5.83E-4
18 SGTC_1125 tnp00248 3.23 1.3 µM 4.36E-4 74 6.10E-4
19 SGTC_376 3970-0862 3.13 59.1 µM 6.35E-4 49 8.71E-4
20 SGTC_1270 0831-1170 3.10 17.3 µM 7.02E-4 39 9.57E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.388 4.49E-121 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.345 2.41E-94 YMR036C MIH1 hom Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
0.326 5.08E-84 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.297 3.16E-69 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.282 2.62E-62 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.268 3.41E-56 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.266 2.76E-55 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization
0.259 1.90E-52 YKL053W_d YKL053W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1
0.256 2.49E-51 YOR195W SLK19 hom Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate
0.248 4.56E-48 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.241 1.26E-45 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.230 1.29E-41 YOR091W TMA46 hom Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p
0.229 2.68E-41 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.226 2.90E-40 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.222 1.14E-38 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication