YML120C / NDI1

NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID

Zygosity: Homozygous strain
fixedexpanded
Profile for YML120C / NDI1

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:4.40|P-value:3.03E-7 ID:SGTC_75|Compound:0159-0059|FD-Score:-2.80|P-value:7.15E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.22|P-value:1.21E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.98|P-value:3.15E-6 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.08|P-value:2.27E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.87|P-value:5.67E-6 ID:SGTC_357|Compound:1325-0123|FD-Score:5.05|P-value:4.84E-9 ID:SGTC_359|Compound:0081-0058|FD-Score:3.34|P-value:7.61E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.27|P-value:9.49E-5 ID:SGTC_465|Compound:cgp-37157|FD-Score:3.74|P-value:1.13E-5 ID:SGTC_470|Compound:aa-861|FD-Score:3.60|P-value:2.27E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.24|P-value:1.20E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:2.87|P-value:5.61E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:-3.29|P-value:9.03E-5 ID:SGTC_693|Compound:4161-2696|FD-Score:-2.73|P-value:9.21E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.75|P-value:1.04E-5 ID:SGTC_899|Compound:1083-0020|FD-Score:4.07|P-value:1.89E-6 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.62|P-value:2.03E-5 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.94|P-value:3.81E-6 ID:SGTC_1317|Compound:1273-0028|FD-Score:2.87|P-value:5.61E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.11|P-value:2.07E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.24|P-value:1.17E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.34|P-value:7.72E-5 ID:SGTC_1738|Compound:st035555|FD-Score:-2.71|P-value:9.80E-4 ID:SGTC_1744|Compound:st037937|FD-Score:2.85|P-value:6.28E-4 ID:SGTC_1745|Compound:st081495|FD-Score:2.77|P-value:8.43E-4 ID:SGTC_1746|Compound:st038117|FD-Score:2.98|P-value:3.64E-4 ID:SGTC_1784|Compound:st039334|FD-Score:4.66|P-value:6.19E-8 ID:SGTC_1982|Compound:st072467|FD-Score:6.37|P-value:2.35E-13 ID:SGTC_1984|Compound:st072354|FD-Score:-4.26|P-value:5.98E-7 ID:SGTC_2033|Compound:5192550|FD-Score:2.90|P-value:5.15E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-5.84|P-value:1.45E-11 ID:SGTC_2308|Compound:7584454|FD-Score:-2.71|P-value:9.87E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-3.37|P-value:6.25E-5 ID:SGTC_2350|Compound:9023895|FD-Score:3.13|P-value:1.91E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.15|P-value:1.74E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.36|P-value:7.08E-5 ID:SGTC_2534|Compound:helenine|FD-Score:-2.82|P-value:6.47E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:3.93|P-value:4.17E-6 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.25|P-value:1.15E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.98|P-value:3.18E-6 ID:SGTC_2823|Compound:7987624|FD-Score:3.31|P-value:8.80E-5 ID:SGTC_2910|Compound:7948405|FD-Score:2.87|P-value:5.60E-4 ID:SGTC_2933|Compound:9026794|FD-Score:2.95|P-value:4.13E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.15|P-value:1.25E-6 ID:SGTC_3087|Compound:9117406|FD-Score:2.90|P-value:4.98E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.49|P-value:3.76E-5 ID:SGTC_3322|Compound:9139058|FD-Score:-3.26|P-value:1.00E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.03|P-value:2.81E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:4.40|P-value:3.03E-7 ID:SGTC_75|Compound:0159-0059|FD-Score:-2.80|P-value:7.15E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.22|P-value:1.21E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.98|P-value:3.15E-6 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.08|P-value:2.27E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.87|P-value:5.67E-6 ID:SGTC_357|Compound:1325-0123|FD-Score:5.05|P-value:4.84E-9 ID:SGTC_359|Compound:0081-0058|FD-Score:3.34|P-value:7.61E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.27|P-value:9.49E-5 ID:SGTC_465|Compound:cgp-37157|FD-Score:3.74|P-value:1.13E-5 ID:SGTC_470|Compound:aa-861|FD-Score:3.60|P-value:2.27E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.24|P-value:1.20E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:2.87|P-value:5.61E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:-3.29|P-value:9.03E-5 ID:SGTC_693|Compound:4161-2696|FD-Score:-2.73|P-value:9.21E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.75|P-value:1.04E-5 ID:SGTC_899|Compound:1083-0020|FD-Score:4.07|P-value:1.89E-6 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.62|P-value:2.03E-5 ID:SGTC_1200|Compound:1643-0193|FD-Score:3.94|P-value:3.81E-6 ID:SGTC_1317|Compound:1273-0028|FD-Score:2.87|P-value:5.61E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.11|P-value:2.07E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.24|P-value:1.17E-4 ID:SGTC_1711|Compound:st032263|FD-Score:3.34|P-value:7.72E-5 ID:SGTC_1738|Compound:st035555|FD-Score:-2.71|P-value:9.80E-4 ID:SGTC_1744|Compound:st037937|FD-Score:2.85|P-value:6.28E-4 ID:SGTC_1745|Compound:st081495|FD-Score:2.77|P-value:8.43E-4 ID:SGTC_1746|Compound:st038117|FD-Score:2.98|P-value:3.64E-4 ID:SGTC_1784|Compound:st039334|FD-Score:4.66|P-value:6.19E-8 ID:SGTC_1982|Compound:st072467|FD-Score:6.37|P-value:2.35E-13 ID:SGTC_1984|Compound:st072354|FD-Score:-4.26|P-value:5.98E-7 ID:SGTC_2033|Compound:5192550|FD-Score:2.90|P-value:5.15E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-5.84|P-value:1.45E-11 ID:SGTC_2308|Compound:7584454|FD-Score:-2.71|P-value:9.87E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-3.37|P-value:6.25E-5 ID:SGTC_2350|Compound:9023895|FD-Score:3.13|P-value:1.91E-4 ID:SGTC_2450|Compound:5739737|FD-Score:3.15|P-value:1.74E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.36|P-value:7.08E-5 ID:SGTC_2534|Compound:helenine|FD-Score:-2.82|P-value:6.47E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:3.93|P-value:4.17E-6 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.25|P-value:1.15E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.98|P-value:3.18E-6 ID:SGTC_2823|Compound:7987624|FD-Score:3.31|P-value:8.80E-5 ID:SGTC_2910|Compound:7948405|FD-Score:2.87|P-value:5.60E-4 ID:SGTC_2933|Compound:9026794|FD-Score:2.95|P-value:4.13E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.15|P-value:1.25E-6 ID:SGTC_3087|Compound:9117406|FD-Score:2.90|P-value:4.98E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.49|P-value:3.76E-5 ID:SGTC_3322|Compound:9139058|FD-Score:-3.26|P-value:1.00E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.03|P-value:2.81E-4

Top fitness defect scores for YML120C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1982 st072467 6.37 71.9 µM 2.35E-13 9 9.40E-11
2 SGTC_357 1325-0123 5.05 420.0 µM 4.84E-9 1 2.16E-7
3 SGTC_1784 st039334 4.66 36.3 µM 6.19E-8 9 1.59E-6
4 SGTC_41 0478-0632 4.40 82.6 µM 3.03E-7 19 5.49E-6
5 SGTC_2939 9044578 4.15 71.4 µM 1.25E-6 33 1.66E-5
6 SGTC_899 1083-0020 4.07 478.0 µM 1.89E-6 21 2.30E-5
7 SGTC_351 caspofungin 3.98 25.0 nM 3.15E-6 cell wall 95 3.44E-5
8 SGTC_2805 7950783 3.98 58.4 µM 3.18E-6 31 3.46E-5
9 SGTC_1200 1643-0193 3.94 18.4 µM 3.81E-6 17 3.99E-5
10 SGTC_2740 felodipine 3.93 17.1 µM 4.17E-6 19 4.28E-5
11 SGTC_356 1634-0012 3.87 32.5 µM 5.67E-6 27 5.45E-5
12 SGTC_779 1360-0071 3.75 233.0 µM 1.04E-5 fatty acid desaturase (OLE1) 35 8.75E-5
13 SGTC_465 cgp-37157 3.74 41.0 µM 1.13E-5 13 9.35E-5
14 SGTC_1157 4092-0394 3.62 27.6 µM 2.03E-5 38 1.48E-4
15 SGTC_470 aa-861 3.60 153.0 µM 2.27E-5 sphingolipid biosynthesis & PDR1 70 1.62E-4
16 SGTC_3125 9127534 3.49 49.5 µM 3.76E-5 21 2.41E-4
17 SGTC_2503 beta-caryophyllene alcohol 3.36 24.7 µM 7.08E-5 21 3.96E-4
18 SGTC_359 0081-0058 3.34 15.9 µM 7.61E-5 60S ribosome export 79 4.19E-4
19 SGTC_1711 st032263 3.34 62.8 µM 7.72E-5 31 4.24E-4
20 SGTC_2823 7987624 3.31 58.4 µM 8.80E-5 64 4.70E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 6.48E-14 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.123 9.92E-13 YJR017C ESS1 het Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3
0.108 3.48E-10 YFR025C HIS2 hom Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
0.106 6.72E-10 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.104 1.71E-9 YML054C-A_p YML054C-A_p hom Putative protein of unknown function
0.098 1.44E-8 YBR263W SHM1 hom Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine
0.095 3.74E-8 YKL070W_p YKL070W_p hom Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.093 5.97E-8 YJL141C YAK1 hom Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose
0.090 1.56E-7 YGL259W_p YPS5_p hom Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p
0.089 2.46E-7 YJL078C PRY3 hom Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p
0.084 1.01E-6 YDL134C PPH21 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication
0.084 1.00E-6 YOL125W TRM13 hom 2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases
0.084 1.12E-6 YGR295C COS6 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.083 1.70E-6 YDL138W RGT2 hom Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication
0.079 4.14E-6 YGR117C_p YGR117C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm