YMR002W / MIC17

Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR002W / MIC17

Click on Significant Values for Screen Details ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.73|P-value:1.58E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.91|P-value:1.02E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:3.66|P-value:2.05E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:-3.46|P-value:4.01E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:-3.27|P-value:7.79E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.25|P-value:8.52E-4 ID:SGTC_1628|Compound:st004252|FD-Score:4.06|P-value:4.29E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.41|P-value:4.84E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.09|P-value:3.87E-5 ID:SGTC_1636|Compound:st007707|FD-Score:5.65|P-value:2.34E-8 ID:SGTC_1733|Compound:st037357|FD-Score:3.51|P-value:3.51E-4 ID:SGTC_1736|Compound:st036774|FD-Score:5.10|P-value:4.10E-7 ID:SGTC_1887|Compound:st057648|FD-Score:-3.36|P-value:5.66E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.69|P-value:1.86E-8 ID:SGTC_1967|Compound:st070177|FD-Score:6.44|P-value:2.36E-10 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.21|P-value:2.34E-5 ID:SGTC_2168|Compound:5727979|FD-Score:3.86|P-value:9.58E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.40|P-value:5.14E-4 ID:SGTC_2318|Compound:6029776|FD-Score:4.11|P-value:3.55E-5 ID:SGTC_2321|Compound:7390090|FD-Score:-3.53|P-value:3.16E-4 ID:SGTC_2349|Compound:9023730|FD-Score:-3.56|P-value:2.82E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.45|P-value:4.21E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:-3.29|P-value:7.33E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.29|P-value:7.43E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.40|P-value:5.10E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.50|P-value:3.58E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.45|P-value:4.25E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.39|P-value:5.23E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-4.19|P-value:2.54E-5 ID:SGTC_2842|Compound:9000675|FD-Score:5.40|P-value:8.99E-8 ID:SGTC_2843|Compound:9000894|FD-Score:-3.67|P-value:1.90E-4 ID:SGTC_2850|Compound:9015429|FD-Score:4.29|P-value:1.66E-5 ID:SGTC_2923|Compound:7992654|FD-Score:3.33|P-value:6.36E-4 ID:SGTC_2941|Compound:9056145|FD-Score:-3.56|P-value:2.85E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.81|P-value:1.13E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-5.99|P-value:3.42E-9 ID:SGTC_2986|Compound:9022445|FD-Score:-4.12|P-value:3.29E-5 ID:SGTC_3003|Compound:9075612|FD-Score:6.90|P-value:1.30E-11 ID:SGTC_3070|Compound:9117005|FD-Score:3.90|P-value:8.29E-5 ID:SGTC_3286|Compound:9117135|FD-Score:3.75|P-value:1.46E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.73|P-value:1.58E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.91|P-value:1.02E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:3.66|P-value:2.05E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:-3.46|P-value:4.01E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:-3.27|P-value:7.79E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.25|P-value:8.52E-4 ID:SGTC_1628|Compound:st004252|FD-Score:4.06|P-value:4.29E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.41|P-value:4.84E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:4.09|P-value:3.87E-5 ID:SGTC_1636|Compound:st007707|FD-Score:5.65|P-value:2.34E-8 ID:SGTC_1733|Compound:st037357|FD-Score:3.51|P-value:3.51E-4 ID:SGTC_1736|Compound:st036774|FD-Score:5.10|P-value:4.10E-7 ID:SGTC_1887|Compound:st057648|FD-Score:-3.36|P-value:5.66E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.69|P-value:1.86E-8 ID:SGTC_1967|Compound:st070177|FD-Score:6.44|P-value:2.36E-10 ID:SGTC_2130|Compound:NSC 7|FD-Score:4.21|P-value:2.34E-5 ID:SGTC_2168|Compound:5727979|FD-Score:3.86|P-value:9.58E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.40|P-value:5.14E-4 ID:SGTC_2318|Compound:6029776|FD-Score:4.11|P-value:3.55E-5 ID:SGTC_2321|Compound:7390090|FD-Score:-3.53|P-value:3.16E-4 ID:SGTC_2349|Compound:9023730|FD-Score:-3.56|P-value:2.82E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.45|P-value:4.21E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:-3.29|P-value:7.33E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.29|P-value:7.43E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.40|P-value:5.10E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.50|P-value:3.58E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.45|P-value:4.25E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.39|P-value:5.23E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-4.19|P-value:2.54E-5 ID:SGTC_2842|Compound:9000675|FD-Score:5.40|P-value:8.99E-8 ID:SGTC_2843|Compound:9000894|FD-Score:-3.67|P-value:1.90E-4 ID:SGTC_2850|Compound:9015429|FD-Score:4.29|P-value:1.66E-5 ID:SGTC_2923|Compound:7992654|FD-Score:3.33|P-value:6.36E-4 ID:SGTC_2941|Compound:9056145|FD-Score:-3.56|P-value:2.85E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.81|P-value:1.13E-4 ID:SGTC_2976|Compound:9009005|FD-Score:-5.99|P-value:3.42E-9 ID:SGTC_2986|Compound:9022445|FD-Score:-4.12|P-value:3.29E-5 ID:SGTC_3003|Compound:9075612|FD-Score:6.90|P-value:1.30E-11 ID:SGTC_3070|Compound:9117005|FD-Score:3.90|P-value:8.29E-5 ID:SGTC_3286|Compound:9117135|FD-Score:3.75|P-value:1.46E-4

Top fitness defect scores for YMR002W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3003 9075612 6.90 71.4 µM 1.30E-11 1 2.68E-12
2 SGTC_1967 st070177 6.44 51.4 µM 2.36E-10 1 5.92E-11
3 SGTC_1926 methyl fluorone black 5.69 53.6 µM 1.86E-8 DNA intercalators 22 6.28E-9
4 SGTC_1636 st007707 5.65 68.9 µM 2.34E-8 22 8.01E-9
5 SGTC_2842 9000675 5.40 19.5 µM 8.99E-8 2 3.37E-8
6 SGTC_1736 st036774 5.10 51.0 µM 4.10E-7 13 1.70E-7
7 SGTC_2850 9015429 4.29 58.4 µM 1.66E-5 7 8.81E-6
8 SGTC_2130 NSC 7 4.21 2.5 µM 2.34E-5 copper-dependent oxidative stress 18 1.27E-5
9 SGTC_2318 6029776 4.11 164.0 µM 3.55E-5 26 1.98E-5
10 SGTC_1631 benzylvanillin 4.09 81.9 µM 3.87E-5 Golgi 24 2.17E-5
11 SGTC_1628 st004252 4.06 77.7 µM 4.29E-5 19 2.42E-5
12 SGTC_3070 9117005 3.90 49.5 µM 8.29E-5 5 4.89E-5
13 SGTC_2168 5727979 3.86 200.0 µM 9.58E-5 19 5.71E-5
14 SGTC_2951 9072950 3.81 58.1 µM 1.13E-4 ERG2 28 6.81E-5
15 SGTC_3286 9117135 3.75 37.2 µM 1.46E-4 19 8.97E-5
16 SGTC_238 5hr heat shock (37°C) + nsc-638432 3.73 8.9 µM 1.58E-4 heat shock/prefoldin 50 9.73E-5
17 SGTC_355 1311-2252 3.66 105.0 µM 2.05E-4 28 1.28E-4
18 SGTC_1733 st037357 3.51 54.9 µM 3.51E-4 60S ribosome export 51 2.28E-4
19 SGTC_2578 7,8-dihydroxyflavone 3.50 64.4 µM 3.58E-4 46 2.33E-4
20 SGTC_2482 5981709 3.45 142.7 µM 4.21E-4 PDR1 55 2.76E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 4.06E-12 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.101 5.36E-9 YMR253C_p YMR253C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
0.096 2.46E-8 YGR234W YHB1 hom Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.096 2.88E-8 YIL163C_p YIL163C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.095 3.30E-8 YEL068C_p YEL068C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.094 5.63E-8 YPL236C ENV7 hom Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)
0.093 7.36E-8 YGL257C MNT2 hom Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans
0.090 1.65E-7 YGR179C OKP1 het Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7
0.082 1.97E-6 YGR260W TNA1 hom High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
0.081 2.71E-6 YBR152W SPP381 het mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p
0.080 3.05E-6 YKL137W CMC1 hom Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif
0.080 3.58E-6 YNL272C SEC2 het Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles
0.079 5.37E-6 YER099C PRS2 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication
0.077 9.10E-6 YAL033W POP5 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.073 2.12E-5 YGL057C GEP7 hom Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies