YMR004W / MVP1

Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR004W / MVP1

Click on Significant Values for Screen Details ID:SGTC_76|Compound:0433-0009|FD-Score:3.29|P-value:8.79E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:3.34|P-value:7.58E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.31|P-value:8.44E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.37|P-value:5.68E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.41|P-value:5.89E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:-3.52|P-value:3.40E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.99|P-value:7.38E-5 ID:SGTC_308|Compound:4092-1169|FD-Score:5.70|P-value:2.72E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.70|P-value:1.82E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.94|P-value:1.01E-6 ID:SGTC_763|Compound:3453-1109|FD-Score:-3.21|P-value:9.74E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.40|P-value:5.10E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.45|P-value:5.15E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:-4.66|P-value:3.58E-6 ID:SGTC_962|Compound:1254-0300|FD-Score:7.50|P-value:4.24E-13 ID:SGTC_966|Compound:1300-0360|FD-Score:4.99|P-value:1.00E-6 ID:SGTC_968|Compound:1309-0633|FD-Score:-5.49|P-value:6.32E-8 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.13|P-value:4.28E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.34|P-value:7.55E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.36|P-value:7.10E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.50|P-value:4.45E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.41|P-value:5.99E-4 ID:SGTC_1646|Compound:st011709|FD-Score:4.35|P-value:1.71E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.34|P-value:7.61E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-3.98|P-value:6.25E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.71|P-value:2.09E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.59|P-value:3.19E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.65|P-value:2.20E-4 ID:SGTC_2058|Compound:5236698|FD-Score:4.11|P-value:4.65E-5 ID:SGTC_2069|Compound:5228469|FD-Score:3.90|P-value:1.05E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.76|P-value:1.76E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.28|P-value:7.68E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.25|P-value:8.40E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.79|P-value:1.58E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.82|P-value:1.40E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:3.29|P-value:8.79E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:3.34|P-value:7.58E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.31|P-value:8.44E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.37|P-value:5.68E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.41|P-value:5.89E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:-3.52|P-value:3.40E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.99|P-value:7.38E-5 ID:SGTC_308|Compound:4092-1169|FD-Score:5.70|P-value:2.72E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.70|P-value:1.82E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.94|P-value:1.01E-6 ID:SGTC_763|Compound:3453-1109|FD-Score:-3.21|P-value:9.74E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-3.40|P-value:5.10E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:3.45|P-value:5.15E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:-4.66|P-value:3.58E-6 ID:SGTC_962|Compound:1254-0300|FD-Score:7.50|P-value:4.24E-13 ID:SGTC_966|Compound:1300-0360|FD-Score:4.99|P-value:1.00E-6 ID:SGTC_968|Compound:1309-0633|FD-Score:-5.49|P-value:6.32E-8 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.13|P-value:4.28E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.34|P-value:7.55E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.36|P-value:7.10E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.50|P-value:4.45E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.41|P-value:5.99E-4 ID:SGTC_1646|Compound:st011709|FD-Score:4.35|P-value:1.71E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.34|P-value:7.61E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-3.98|P-value:6.25E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.71|P-value:2.09E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.59|P-value:3.19E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.65|P-value:2.20E-4 ID:SGTC_2058|Compound:5236698|FD-Score:4.11|P-value:4.65E-5 ID:SGTC_2069|Compound:5228469|FD-Score:3.90|P-value:1.05E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.76|P-value:1.76E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.28|P-value:7.68E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.25|P-value:8.40E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.79|P-value:1.58E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.82|P-value:1.40E-4

Top fitness defect scores for YMR004W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_962 1254-0300 7.50 21.5 µM 4.24E-13 3 3.28E-14
2 SGTC_308 4092-1169 5.70 104.0 µM 2.72E-8 plasma membrane duress 23 5.87E-9
3 SGTC_966 1300-0360 4.99 30.2 µM 1.00E-6 heme requiring 8 3.02E-7
4 SGTC_1646 st011709 4.35 75.6 µM 1.71E-5 3 6.72E-6
5 SGTC_1131 3454-3128 4.13 32.3 µM 4.28E-5 36 1.83E-5
6 SGTC_2058 5236698 4.11 133.0 µM 4.65E-5 24 2.00E-5
7 SGTC_301 4119-0100 3.99 24.5 µM 7.38E-5 NEO1 81 3.32E-5
8 SGTC_2069 5228469 3.90 200.0 µM 1.05E-4 14 4.89E-5
9 SGTC_2795 7780010 3.82 54.5 µM 1.40E-4 32 6.66E-5
10 SGTC_2762 leflunomide 3.79 42.1 µM 1.58E-4 38 7.61E-5
11 SGTC_2427 5545055 3.76 42.8 µM 1.76E-4 17 8.55E-5
12 SGTC_1844 rapamycin 3.71 4.0 nM 2.09E-4 181 1.03E-4
13 SGTC_2051 5263410 3.59 176.0 µM 3.19E-4 24 1.64E-4
14 SGTC_1416 3966-0321 3.50 25.3 µM 4.45E-4 34 2.36E-4
15 SGTC_957 1187-1561 3.45 14.1 µM 5.15E-4 39 2.76E-4
16 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 3.41 44.4 nM 5.89E-4 DNA damage response 41 3.20E-4
17 SGTC_1439 4092-1168 3.41 46.0 µM 5.99E-4 22 3.26E-4
18 SGTC_1287 0971-0001 3.36 34.6 µM 7.10E-4 sphingolipid biosynthesis & PDR1 67 3.93E-4
19 SGTC_1269 0831-0796 3.34 3.0 µM 7.55E-4 60S ribosome export 29 4.20E-4
20 SGTC_82 0054-0107 3.34 293.8 µM 7.58E-4 19 4.21E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.163 2.30E-21 YGR012W YGR012W hom Putative cysteine synthase, localized to the mitochondrial outer membrane
0.150 3.02E-18 YGR040W KSS1 hom Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
0.134 5.61E-15 YHL002W HSE1 hom Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
0.124 6.76E-13 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.120 3.66E-12 YBL071W-A KTI11 hom Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs
0.118 8.17E-12 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.115 2.68E-11 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.113 4.74E-11 YGL156W AMS1 hom Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
0.112 6.67E-11 YML095C RAD10 hom Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
0.110 1.51E-10 YPL020C ULP1 het Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions
0.108 3.58E-10 YMR201C RAD14 hom Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
0.108 4.15E-10 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.105 9.59E-10 YDR105C TMS1 hom Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance
0.103 1.94E-9 YGR200C ELP2 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.101 4.18E-9 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication