YMR006C / PLB2

Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR006C / PLB2

Click on Significant Values for Screen Details ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:3.11|P-value:3.84E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:3.18|P-value:3.02E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:3.82|P-value:2.05E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:-4.21|P-value:8.13E-6 ID:SGTC_284|Compound:0988-0104|FD-Score:2.87|P-value:9.51E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:2.98|P-value:6.22E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-6.64|P-value:3.25E-12 ID:SGTC_424|Compound:splitomicin|FD-Score:7.91|P-value:2.38E-17 ID:SGTC_430|Compound:0958-0115|FD-Score:-3.93|P-value:2.94E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.99|P-value:2.25E-5 ID:SGTC_618|Compound:k072-0232|FD-Score:3.05|P-value:4.89E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.28|P-value:2.00E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.82|P-value:2.04E-5 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.36|P-value:3.05E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.05|P-value:4.85E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.36|P-value:1.45E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.36|P-value:3.07E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.07|P-value:9.15E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.06|P-value:4.62E-4 ID:SGTC_1654|Compound:st012436|FD-Score:3.89|P-value:1.48E-5 ID:SGTC_1793|Compound:st048256|FD-Score:3.49|P-value:8.62E-5 ID:SGTC_1813|Compound:st051246|FD-Score:3.89|P-value:1.46E-5 ID:SGTC_1821|Compound:st053465|FD-Score:-3.62|P-value:1.10E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.85|P-value:9.95E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.17|P-value:6.26E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-6.28|P-value:4.36E-11 ID:SGTC_2412|Compound:st077135|FD-Score:4.29|P-value:2.09E-6 ID:SGTC_2414|Compound:st077232|FD-Score:-3.77|P-value:5.71E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.71|P-value:7.61E-5 ID:SGTC_2625|Compound:euphol|FD-Score:3.39|P-value:1.30E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-3.21|P-value:5.50E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-4.10|P-value:1.34E-5 ID:SGTC_2791|Compound:5663188|FD-Score:3.06|P-value:4.72E-4 ID:SGTC_2886|Compound:9058944|FD-Score:2.90|P-value:8.57E-4 ID:SGTC_2891|Compound:9063876|FD-Score:3.41|P-value:1.21E-4 ID:SGTC_2898|Compound:9056270|FD-Score:2.97|P-value:6.65E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.21|P-value:5.46E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-6.76|P-value:1.33E-12 ID:SGTC_2992|Compound:9074591|FD-Score:-3.58|P-value:1.27E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.72|P-value:7.09E-5 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:3.11|P-value:3.84E-4 ID:SGTC_32|Compound:0928-0142|FD-Score:3.18|P-value:3.02E-4 ID:SGTC_185|Compound:k048-0037|FD-Score:3.82|P-value:2.05E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:-4.21|P-value:8.13E-6 ID:SGTC_284|Compound:0988-0104|FD-Score:2.87|P-value:9.51E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:2.98|P-value:6.22E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-6.64|P-value:3.25E-12 ID:SGTC_424|Compound:splitomicin|FD-Score:7.91|P-value:2.38E-17 ID:SGTC_430|Compound:0958-0115|FD-Score:-3.93|P-value:2.94E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.99|P-value:2.25E-5 ID:SGTC_618|Compound:k072-0232|FD-Score:3.05|P-value:4.89E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.28|P-value:2.00E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.82|P-value:2.04E-5 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.36|P-value:3.05E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.05|P-value:4.85E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.36|P-value:1.45E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.36|P-value:3.07E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.07|P-value:9.15E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.06|P-value:4.62E-4 ID:SGTC_1654|Compound:st012436|FD-Score:3.89|P-value:1.48E-5 ID:SGTC_1793|Compound:st048256|FD-Score:3.49|P-value:8.62E-5 ID:SGTC_1813|Compound:st051246|FD-Score:3.89|P-value:1.46E-5 ID:SGTC_1821|Compound:st053465|FD-Score:-3.62|P-value:1.10E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.85|P-value:9.95E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.17|P-value:6.26E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-6.28|P-value:4.36E-11 ID:SGTC_2412|Compound:st077135|FD-Score:4.29|P-value:2.09E-6 ID:SGTC_2414|Compound:st077232|FD-Score:-3.77|P-value:5.71E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.71|P-value:7.61E-5 ID:SGTC_2625|Compound:euphol|FD-Score:3.39|P-value:1.30E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-3.21|P-value:5.50E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-4.10|P-value:1.34E-5 ID:SGTC_2791|Compound:5663188|FD-Score:3.06|P-value:4.72E-4 ID:SGTC_2886|Compound:9058944|FD-Score:2.90|P-value:8.57E-4 ID:SGTC_2891|Compound:9063876|FD-Score:3.41|P-value:1.21E-4 ID:SGTC_2898|Compound:9056270|FD-Score:2.97|P-value:6.65E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.21|P-value:5.46E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-6.76|P-value:1.33E-12 ID:SGTC_2992|Compound:9074591|FD-Score:-3.58|P-value:1.27E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.72|P-value:7.09E-5

Top fitness defect scores for YMR006C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_424 splitomicin 7.91 100.0 mM 2.38E-17 2 1.30E-15
2 SGTC_2412 st077135 4.29 33.4 µM 2.09E-6 17 8.76E-6
3 SGTC_1813 st051246 3.89 8.6 µM 1.46E-5 TSC3-RPN4 13 5.00E-5
4 SGTC_1654 st012436 3.89 41.8 µM 1.48E-5 16 5.04E-5
5 SGTC_763 3453-1109 3.82 128.0 µM 2.04E-5 21 6.73E-5
6 SGTC_185 k048-0037 3.82 25.5 µM 2.05E-5 RSC & ERG11 13 6.75E-5
7 SGTC_1793 st048256 3.49 72.2 µM 8.62E-5 6 2.44E-4
8 SGTC_2891 9063876 3.41 19.5 µM 1.21E-4 15 3.30E-4
9 SGTC_2625 euphol 3.39 100.0 µM 1.30E-4 54 3.51E-4
10 SGTC_1134 3477-0009 3.36 42.5 µM 1.45E-4 72 3.87E-4
11 SGTC_676 falcarinol 3.28 140.0 µM 2.00E-4 83 5.17E-4
12 SGTC_32 0928-0142 3.18 34.1 µM 3.02E-4 TSC3-RPN4 22 7.46E-4
13 SGTC_30 5-(2-thienylidene)-Rhodanine 3.11 28.7 µM 3.84E-4 17 9.25E-4
14 SGTC_1606 st000094 3.06 49.2 µM 4.62E-4 60S ribosome export 54 0.00109
15 SGTC_2791 5663188 3.06 71.4 µM 4.72E-4 RPP1 & pyrimidine depletion 60 0.00111
16 SGTC_916 4466-0038 3.05 42.0 nM 4.85E-4 cell wall 133 0.00114
17 SGTC_618 k072-0232 3.05 33.2 µM 4.89E-4 60S ribosome export 38 0.00115
18 SGTC_326 k292-0812 2.98 17.5 µM 6.22E-4 29 0.00142
19 SGTC_2898 9056270 2.97 58.4 µM 6.65E-4 24 0.00151
20 SGTC_2886 9058944 2.90 52.0 µM 8.57E-4 14 0.00189

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 2.76E-18 YJR038C_d YJR038C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.130 4.00E-14 YNL187W SWT21 hom Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats
0.129 5.66E-14 YER057C HMF1 hom Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro
0.122 1.44E-12 YJL050W MTR4 het ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
0.119 4.63E-12 YDR104C SPO71 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains
0.117 1.02E-11 YBR050C REG2 hom Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
0.111 9.69E-11 YER066C-A_d YER066C-A_d hom Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W
0.105 9.09E-10 YFR032C-A RPL29 hom Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog
0.104 2.04E-9 YDR029W_d YDR029W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.102 2.76E-9 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.100 6.94E-9 YBR165W UBS1 hom Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
0.099 9.68E-9 YJL137C GLG2 hom Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication
0.094 4.44E-8 YGR207C CIR1 hom Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response
0.093 5.93E-8 YGL082W_p YGL082W_p hom Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene
0.093 7.08E-8 YDR379W RGA2 hom GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p