YMR011W / HXT2

High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR011W / HXT2

Click on Significant Values for Screen Details ID:SGTC_290|Compound:2043-6722|FD-Score:3.23|P-value:5.63E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:3.77|P-value:7.35E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:4.70|P-value:1.09E-6 ID:SGTC_606|Compound:k015-0008|FD-Score:3.84|P-value:5.40E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:-3.34|P-value:3.94E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.64|P-value:1.23E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.83|P-value:5.76E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:3.24|P-value:5.43E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.65|P-value:1.19E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.34|P-value:3.88E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:4.49|P-value:3.05E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.08|P-value:1.98E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.23|P-value:5.61E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.71|P-value:9.25E-5 ID:SGTC_1683|Compound:st010134|FD-Score:-3.09|P-value:9.31E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.71|P-value:9.17E-5 ID:SGTC_1705|Compound:st027868|FD-Score:4.25|P-value:9.25E-6 ID:SGTC_1764|Compound:st044502|FD-Score:4.96|P-value:3.00E-7 ID:SGTC_1798|Compound:st045719|FD-Score:-3.51|P-value:2.06E-4 ID:SGTC_1817|Compound:st052116|FD-Score:4.00|P-value:2.85E-5 ID:SGTC_1903|Compound:st060211|FD-Score:-3.15|P-value:7.70E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.87|P-value:4.78E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.10|P-value:8.88E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.66|P-value:1.36E-6 ID:SGTC_2198|Compound:6589944|FD-Score:3.17|P-value:6.93E-4 ID:SGTC_2243|Compound:6634756|FD-Score:5.51|P-value:1.45E-8 ID:SGTC_2260|Compound:7964312|FD-Score:3.84|P-value:5.49E-5 ID:SGTC_2357|Compound:9067248|FD-Score:3.31|P-value:4.35E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.48|P-value:2.32E-4 ID:SGTC_2468|Compound:5987765|FD-Score:-3.22|P-value:5.91E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.62|P-value:1.37E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:7.96|P-value:5.50E-16 ID:SGTC_2584|Compound:androsterone|FD-Score:4.76|P-value:8.24E-7 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.80|P-value:6.52E-5 ID:SGTC_2713|Compound:st079149|FD-Score:3.10|P-value:8.96E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:5.10|P-value:1.44E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.40|P-value:3.09E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.69|P-value:1.02E-4 ID:SGTC_2837|Compound:9008476|FD-Score:6.72|P-value:6.70E-12 ID:SGTC_2842|Compound:9000675|FD-Score:3.71|P-value:9.14E-5 ID:SGTC_2845|Compound:9003024|FD-Score:-4.27|P-value:8.58E-6 ID:SGTC_2852|Compound:9023854|FD-Score:4.29|P-value:7.78E-6 ID:SGTC_2854|Compound:9024559|FD-Score:4.58|P-value:1.97E-6 ID:SGTC_2882|Compound:9058044|FD-Score:3.31|P-value:4.23E-4 ID:SGTC_2949|Compound:9072542|FD-Score:7.31|P-value:9.29E-14 ID:SGTC_3237|Compound:9133362|FD-Score:3.17|P-value:7.12E-4 ID:SGTC_3259|Compound:9138485|FD-Score:4.70|P-value:1.09E-6 ID:SGTC_3293|Compound:9120939|FD-Score:3.07|P-value:9.96E-4 ID:SGTC_3295|Compound:9122362|FD-Score:-4.21|P-value:1.12E-5 ID:SGTC_290|Compound:2043-6722|FD-Score:3.23|P-value:5.63E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:3.77|P-value:7.35E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:4.70|P-value:1.09E-6 ID:SGTC_606|Compound:k015-0008|FD-Score:3.84|P-value:5.40E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:-3.34|P-value:3.94E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.64|P-value:1.23E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.83|P-value:5.76E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:3.24|P-value:5.43E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.65|P-value:1.19E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.34|P-value:3.88E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:4.49|P-value:3.05E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.08|P-value:1.98E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:3.23|P-value:5.61E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.71|P-value:9.25E-5 ID:SGTC_1683|Compound:st010134|FD-Score:-3.09|P-value:9.31E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.71|P-value:9.17E-5 ID:SGTC_1705|Compound:st027868|FD-Score:4.25|P-value:9.25E-6 ID:SGTC_1764|Compound:st044502|FD-Score:4.96|P-value:3.00E-7 ID:SGTC_1798|Compound:st045719|FD-Score:-3.51|P-value:2.06E-4 ID:SGTC_1817|Compound:st052116|FD-Score:4.00|P-value:2.85E-5 ID:SGTC_1903|Compound:st060211|FD-Score:-3.15|P-value:7.70E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.87|P-value:4.78E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.10|P-value:8.88E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.66|P-value:1.36E-6 ID:SGTC_2198|Compound:6589944|FD-Score:3.17|P-value:6.93E-4 ID:SGTC_2243|Compound:6634756|FD-Score:5.51|P-value:1.45E-8 ID:SGTC_2260|Compound:7964312|FD-Score:3.84|P-value:5.49E-5 ID:SGTC_2357|Compound:9067248|FD-Score:3.31|P-value:4.35E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.48|P-value:2.32E-4 ID:SGTC_2468|Compound:5987765|FD-Score:-3.22|P-value:5.91E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.62|P-value:1.37E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:7.96|P-value:5.50E-16 ID:SGTC_2584|Compound:androsterone|FD-Score:4.76|P-value:8.24E-7 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.80|P-value:6.52E-5 ID:SGTC_2713|Compound:st079149|FD-Score:3.10|P-value:8.96E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:5.10|P-value:1.44E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.40|P-value:3.09E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.69|P-value:1.02E-4 ID:SGTC_2837|Compound:9008476|FD-Score:6.72|P-value:6.70E-12 ID:SGTC_2842|Compound:9000675|FD-Score:3.71|P-value:9.14E-5 ID:SGTC_2845|Compound:9003024|FD-Score:-4.27|P-value:8.58E-6 ID:SGTC_2852|Compound:9023854|FD-Score:4.29|P-value:7.78E-6 ID:SGTC_2854|Compound:9024559|FD-Score:4.58|P-value:1.97E-6 ID:SGTC_2882|Compound:9058044|FD-Score:3.31|P-value:4.23E-4 ID:SGTC_2949|Compound:9072542|FD-Score:7.31|P-value:9.29E-14 ID:SGTC_3237|Compound:9133362|FD-Score:3.17|P-value:7.12E-4 ID:SGTC_3259|Compound:9138485|FD-Score:4.70|P-value:1.09E-6 ID:SGTC_3293|Compound:9120939|FD-Score:3.07|P-value:9.96E-4 ID:SGTC_3295|Compound:9122362|FD-Score:-4.21|P-value:1.12E-5

Top fitness defect scores for YMR011W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2563 tomatine 7.96 8.5 µM 5.50E-16 3 8.64E-16
2 SGTC_2949 9072542 7.31 2.2 µM 9.29E-14 TSC3-RPN4 2 1.36E-13
3 SGTC_2837 9008476 6.72 45.5 µM 6.70E-12 3 9.26E-12
4 SGTC_2243 6634756 5.51 200.0 µM 1.45E-8 3 1.81E-8
5 SGTC_2753 fluvastatin 5.10 17.1 µM 1.44E-7 azole & statin 14 1.74E-7
6 SGTC_1764 st044502 4.96 93.5 µM 3.00E-7 18 3.60E-7
7 SGTC_2584 androsterone 4.76 48.7 µM 8.24E-7 cell wall 86 9.75E-7
8 SGTC_3259 9138485 4.70 49.5 µM 1.09E-6 4 1.28E-6
9 SGTC_514 4466-0038 4.70 2.6 nM 1.09E-6 cell wall 121 1.28E-6
10 SGTC_2126 5251174 4.66 33.9 µM 1.36E-6 14 1.59E-6
11 SGTC_2854 9024559 4.58 71.4 µM 1.97E-6 11 2.30E-6
12 SGTC_1035 k081-0041 4.49 55.2 µM 3.05E-6 Golgi 15 3.54E-6
13 SGTC_2852 9023854 4.29 52.0 µM 7.78E-6 26 8.93E-6
14 SGTC_1705 st027868 4.25 56.3 µM 9.25E-6 5 1.06E-5
15 SGTC_1083 didemethylchlorpromazine sulfoxide 4.08 707.4 nM 1.98E-5 redox potentiating 75 2.25E-5
16 SGTC_1817 st052116 4.00 64.4 µM 2.85E-5 RNA processing & uracil transport 11 3.22E-5
17 SGTC_1980 st071811 3.87 45.7 µM 4.78E-5 RPP1 & pyrimidine depletion 16 5.35E-5
18 SGTC_606 k015-0008 3.84 38.6 µM 5.40E-5 17 6.04E-5
19 SGTC_2260 7964312 3.84 200.0 µM 5.49E-5 15 6.15E-5
20 SGTC_804 1595-0054 3.83 20.9 µM 5.76E-5 sphingolipid biosynthesis & PDR1 38 6.44E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 2.73E-25 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.155 1.38E-19 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.150 2.03E-18 YKL035W UGP1 het UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication
0.148 8.14E-18 YDR018C_p YDR018C_p hom Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication
0.129 5.39E-14 YER067W RGI1 hom Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
0.129 7.59E-14 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.129 8.26E-14 YJL020C BBC1 hom Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches
0.121 2.41E-12 YJR023C_d YJR023C_d het Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing
0.119 4.44E-12 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.118 6.27E-12 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.113 4.81E-11 YOR195W SLK19 hom Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate
0.112 6.76E-11 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.112 8.54E-11 YLR102C APC9 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.110 1.52E-10 YOR296W_p YOR296W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene
0.110 1.60E-10 YDR121W DPB4 hom Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization