YMR019W / STB4

Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay;

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR019W / STB4

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.94|P-value:1.14E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:3.31|P-value:1.92E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:-3.08|P-value:4.33E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:3.56|P-value:6.68E-5 ID:SGTC_433|Compound:pimozide|FD-Score:-2.89|P-value:8.88E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:-3.05|P-value:4.96E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.33|P-value:1.57E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-5.33|P-value:4.31E-9 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.17|P-value:3.01E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.34|P-value:1.57E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.15|P-value:3.31E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.40|P-value:1.28E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.81|P-value:1.89E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.12|P-value:3.77E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.62|P-value:4.68E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.88|P-value:9.17E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.34|P-value:1.67E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:4.65|P-value:2.97E-7 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.59|P-value:5.79E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-5.45|P-value:1.97E-9 ID:SGTC_1352|Compound:1496-0991|FD-Score:-2.89|P-value:8.98E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.57|P-value:5.67E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.49|P-value:8.84E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.63|P-value:4.43E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-2.95|P-value:7.04E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-2.99|P-value:6.16E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-3.89|P-value:1.31E-5 ID:SGTC_1842|Compound:st055362|FD-Score:3.40|P-value:1.33E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.96|P-value:9.66E-6 ID:SGTC_2023|Compound:5144124|FD-Score:3.23|P-value:2.57E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.55|P-value:7.01E-5 ID:SGTC_2127|Compound:5253358|FD-Score:-4.99|P-value:3.67E-8 ID:SGTC_2128|Compound:5255449|FD-Score:-4.79|P-value:1.19E-7 ID:SGTC_2319|Compound:6033012|FD-Score:5.68|P-value:5.25E-10 ID:SGTC_2325|Compound:6158266|FD-Score:-3.16|P-value:3.13E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.80|P-value:2.21E-5 ID:SGTC_2480|Compound:5767542|FD-Score:-4.01|P-value:7.35E-6 ID:SGTC_2487|Compound:5918373|FD-Score:3.67|P-value:4.05E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.04|P-value:5.58E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.30|P-value:1.94E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-3.09|P-value:4.24E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.21|P-value:2.79E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.20|P-value:2.97E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.09|P-value:4.60E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:5.74|P-value:3.43E-10 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:4.42|P-value:1.04E-6 ID:SGTC_2810|Compound:7959871|FD-Score:-3.20|P-value:2.74E-4 ID:SGTC_2838|Compound:9002687|FD-Score:2.97|P-value:7.22E-4 ID:SGTC_2842|Compound:9000675|FD-Score:2.93|P-value:8.27E-4 ID:SGTC_2846|Compound:9008642|FD-Score:4.36|P-value:1.43E-6 ID:SGTC_2944|Compound:9067346|FD-Score:-4.03|P-value:6.74E-6 ID:SGTC_3028|Compound:9087778|FD-Score:-4.53|P-value:5.07E-7 ID:SGTC_3146|Compound:9095609|FD-Score:2.94|P-value:7.98E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.55|P-value:6.86E-5 ID:SGTC_3206|Compound:9114350|FD-Score:3.06|P-value:5.03E-4 ID:SGTC_3259|Compound:9138485|FD-Score:3.97|P-value:9.80E-6 ID:SGTC_3272|Compound:9137413|FD-Score:-3.34|P-value:1.54E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.94|P-value:1.14E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:3.31|P-value:1.92E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:-3.08|P-value:4.33E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:3.56|P-value:6.68E-5 ID:SGTC_433|Compound:pimozide|FD-Score:-2.89|P-value:8.88E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:-3.05|P-value:4.96E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.33|P-value:1.57E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-5.33|P-value:4.31E-9 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.17|P-value:3.01E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.34|P-value:1.57E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.15|P-value:3.31E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.40|P-value:1.28E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.81|P-value:1.89E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.12|P-value:3.77E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.62|P-value:4.68E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.88|P-value:9.17E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.34|P-value:1.67E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:4.65|P-value:2.97E-7 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.59|P-value:5.79E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-5.45|P-value:1.97E-9 ID:SGTC_1352|Compound:1496-0991|FD-Score:-2.89|P-value:8.98E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.57|P-value:5.67E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.49|P-value:8.84E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.63|P-value:4.43E-5 ID:SGTC_1722|Compound:st034304|FD-Score:-2.95|P-value:7.04E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-2.99|P-value:6.16E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-3.89|P-value:1.31E-5 ID:SGTC_1842|Compound:st055362|FD-Score:3.40|P-value:1.33E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.96|P-value:9.66E-6 ID:SGTC_2023|Compound:5144124|FD-Score:3.23|P-value:2.57E-4 ID:SGTC_2037|Compound:5169046|FD-Score:3.55|P-value:7.01E-5 ID:SGTC_2127|Compound:5253358|FD-Score:-4.99|P-value:3.67E-8 ID:SGTC_2128|Compound:5255449|FD-Score:-4.79|P-value:1.19E-7 ID:SGTC_2319|Compound:6033012|FD-Score:5.68|P-value:5.25E-10 ID:SGTC_2325|Compound:6158266|FD-Score:-3.16|P-value:3.13E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.80|P-value:2.21E-5 ID:SGTC_2480|Compound:5767542|FD-Score:-4.01|P-value:7.35E-6 ID:SGTC_2487|Compound:5918373|FD-Score:3.67|P-value:4.05E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.04|P-value:5.58E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.30|P-value:1.94E-4 ID:SGTC_2537|Compound:larixol|FD-Score:-3.09|P-value:4.24E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.21|P-value:2.79E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.20|P-value:2.97E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.09|P-value:4.60E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:5.74|P-value:3.43E-10 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:4.42|P-value:1.04E-6 ID:SGTC_2810|Compound:7959871|FD-Score:-3.20|P-value:2.74E-4 ID:SGTC_2838|Compound:9002687|FD-Score:2.97|P-value:7.22E-4 ID:SGTC_2842|Compound:9000675|FD-Score:2.93|P-value:8.27E-4 ID:SGTC_2846|Compound:9008642|FD-Score:4.36|P-value:1.43E-6 ID:SGTC_2944|Compound:9067346|FD-Score:-4.03|P-value:6.74E-6 ID:SGTC_3028|Compound:9087778|FD-Score:-4.53|P-value:5.07E-7 ID:SGTC_3146|Compound:9095609|FD-Score:2.94|P-value:7.98E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.55|P-value:6.86E-5 ID:SGTC_3206|Compound:9114350|FD-Score:3.06|P-value:5.03E-4 ID:SGTC_3259|Compound:9138485|FD-Score:3.97|P-value:9.80E-6 ID:SGTC_3272|Compound:9137413|FD-Score:-3.34|P-value:1.54E-4

Top fitness defect scores for YMR019W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2771 fluoxetine 5.74 41.0 µM 3.43E-10 5 4.79E-9
2 SGTC_2319 6033012 5.68 152.6 µM 5.25E-10 tubulin folding & SWR complex 15 6.92E-9
3 SGTC_1236 0330-0013 4.65 258.0 µM 2.97E-7 3 1.69E-6
4 SGTC_2775 cyproheptadine 4.42 69.6 µM 1.04E-6 9 5.03E-6
5 SGTC_2846 9008642 4.36 19.5 µM 1.43E-6 16 6.64E-6
6 SGTC_3259 9138485 3.97 49.5 µM 9.80E-6 11 3.53E-5
7 SGTC_6 0844-0013 3.94 19.8 µM 1.14E-5 89 4.02E-5
8 SGTC_2349 9023730 3.80 187.1 µM 2.21E-5 27 7.17E-5
9 SGTC_2487 5918373 3.67 44.0 µM 4.05E-5 21 1.21E-4
10 SGTC_1239 0337-0584 3.59 35.4 µM 5.79E-5 unfolded protein response 71 1.66E-4
11 SGTC_280 3448-3607 3.56 3.0 µM 6.68E-5 60S ribosome export 19 1.88E-4
12 SGTC_3182 9108849 3.55 49.5 µM 6.86E-5 RPP1 & pyrimidine depletion 18 1.92E-4
13 SGTC_2037 5169046 3.55 200.0 µM 7.01E-5 60S ribosome export 22 1.96E-4
14 SGTC_1378 2093-0007 3.49 380.0 nM 8.84E-5 34 2.40E-4
15 SGTC_974 1326-0144 3.40 138.0 µM 1.28E-4 ERG2 68 3.31E-4
16 SGTC_1842 st055362 3.40 61.2 µM 1.33E-4 27 3.43E-4
17 SGTC_1235 benzylparaben 3.34 21.5 µM 1.67E-4 25 4.17E-4
18 SGTC_152 4469-0003 3.31 551.2 µM 1.92E-4 41 4.71E-4
19 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.30 3.7 µM 1.94E-4 148 4.76E-4
20 SGTC_2023 5144124 3.23 124.0 µM 2.57E-4 47 6.09E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.228 9.73E-41 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.208 2.94E-34 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.184 4.44E-27 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.174 3.64E-24 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.169 8.56E-23 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.168 1.11E-22 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.162 3.28E-21 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.155 1.98E-19 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.145 3.01E-17 YML042W CAT2 hom Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
0.140 3.65E-16 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.139 6.26E-16 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.133 1.01E-14 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.131 2.72E-14 YKL132C RMA1 hom Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.124 6.24E-13 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.123 8.39E-13 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress