YMR023C / MSS1

Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR023C / MSS1

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:4.12|P-value:1.50E-6 ID:SGTC_52|Compound:0329-0193|FD-Score:3.43|P-value:5.03E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.44|P-value:5.93E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.58|P-value:2.96E-5 ID:SGTC_128|Compound:0906-2981|FD-Score:2.79|P-value:7.57E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.32|P-value:8.05E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:2.95|P-value:3.93E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:3.29|P-value:9.58E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:-3.00|P-value:3.96E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:-2.87|P-value:6.61E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:2.96|P-value:3.91E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.43|P-value:6.11E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:-2.97|P-value:4.35E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.70|P-value:1.34E-5 ID:SGTC_655|Compound:k060-0012|FD-Score:-2.81|P-value:8.51E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.32|P-value:8.01E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:3.42|P-value:5.29E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.13|P-value:2.32E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:-3.30|P-value:1.11E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.37|P-value:6.38E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:-4.21|P-value:1.19E-6 ID:SGTC_911|Compound:3456-4043|FD-Score:2.93|P-value:4.27E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.41|P-value:6.74E-5 ID:SGTC_1115|Compound:galangin|FD-Score:3.13|P-value:1.92E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-4.72|P-value:5.70E-8 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.23|P-value:1.47E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:2.81|P-value:6.95E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.22|P-value:1.29E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.27|P-value:1.01E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.74|P-value:1.08E-5 ID:SGTC_1779|Compound:st039427|FD-Score:2.82|P-value:6.77E-4 ID:SGTC_1914|Compound:st062367|FD-Score:4.80|P-value:2.66E-8 ID:SGTC_1983|Compound:st071813|FD-Score:3.43|P-value:4.91E-5 ID:SGTC_2006|Compound:4011487|FD-Score:3.35|P-value:7.08E-5 ID:SGTC_2057|Compound:5236571|FD-Score:2.82|P-value:6.84E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.86|P-value:5.71E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.36|P-value:6.83E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-2.81|P-value:8.25E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-2.96|P-value:4.58E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:2.86|P-value:5.81E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:2.97|P-value:3.71E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.63|P-value:1.92E-5 ID:SGTC_2851|Compound:9015922|FD-Score:3.48|P-value:3.98E-5 ID:SGTC_2885|Compound:9057732|FD-Score:2.77|P-value:8.20E-4 ID:SGTC_2889|Compound:9059656|FD-Score:5.22|P-value:1.74E-9 ID:SGTC_2894|Compound:9048625|FD-Score:-3.36|P-value:8.37E-5 ID:SGTC_2897|Compound:9048598|FD-Score:2.91|P-value:4.76E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-3.17|P-value:1.96E-4 ID:SGTC_2916|Compound:7875993|FD-Score:4.16|P-value:1.19E-6 ID:SGTC_3066|Compound:9117245|FD-Score:2.89|P-value:5.21E-4 ID:SGTC_3067|Compound:9117431|FD-Score:2.78|P-value:7.86E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.15|P-value:2.14E-4 ID:SGTC_3098|Compound:9119039|FD-Score:2.85|P-value:5.92E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.04|P-value:2.78E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.11|P-value:2.52E-4 ID:SGTC_3251|Compound:9135047|FD-Score:-3.40|P-value:7.12E-5 ID:SGTC_3335|Compound:9143315|FD-Score:2.79|P-value:7.53E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:4.12|P-value:1.50E-6 ID:SGTC_52|Compound:0329-0193|FD-Score:3.43|P-value:5.03E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.44|P-value:5.93E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.58|P-value:2.96E-5 ID:SGTC_128|Compound:0906-2981|FD-Score:2.79|P-value:7.57E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.32|P-value:8.05E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:2.95|P-value:3.93E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:3.29|P-value:9.58E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:-3.00|P-value:3.96E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:-2.87|P-value:6.61E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:2.96|P-value:3.91E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.43|P-value:6.11E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:-2.97|P-value:4.35E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.70|P-value:1.34E-5 ID:SGTC_655|Compound:k060-0012|FD-Score:-2.81|P-value:8.51E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.32|P-value:8.01E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:3.42|P-value:5.29E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:-3.13|P-value:2.32E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:-3.30|P-value:1.11E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.37|P-value:6.38E-5 ID:SGTC_900|Compound:1112-0045|FD-Score:-4.21|P-value:1.19E-6 ID:SGTC_911|Compound:3456-4043|FD-Score:2.93|P-value:4.27E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.41|P-value:6.74E-5 ID:SGTC_1115|Compound:galangin|FD-Score:3.13|P-value:1.92E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-4.72|P-value:5.70E-8 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.23|P-value:1.47E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:2.81|P-value:6.95E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.22|P-value:1.29E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.27|P-value:1.01E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.74|P-value:1.08E-5 ID:SGTC_1779|Compound:st039427|FD-Score:2.82|P-value:6.77E-4 ID:SGTC_1914|Compound:st062367|FD-Score:4.80|P-value:2.66E-8 ID:SGTC_1983|Compound:st071813|FD-Score:3.43|P-value:4.91E-5 ID:SGTC_2006|Compound:4011487|FD-Score:3.35|P-value:7.08E-5 ID:SGTC_2057|Compound:5236571|FD-Score:2.82|P-value:6.84E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.86|P-value:5.71E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.36|P-value:6.83E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-2.81|P-value:8.25E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-2.96|P-value:4.58E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:2.86|P-value:5.81E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:2.97|P-value:3.71E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.63|P-value:1.92E-5 ID:SGTC_2851|Compound:9015922|FD-Score:3.48|P-value:3.98E-5 ID:SGTC_2885|Compound:9057732|FD-Score:2.77|P-value:8.20E-4 ID:SGTC_2889|Compound:9059656|FD-Score:5.22|P-value:1.74E-9 ID:SGTC_2894|Compound:9048625|FD-Score:-3.36|P-value:8.37E-5 ID:SGTC_2897|Compound:9048598|FD-Score:2.91|P-value:4.76E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-3.17|P-value:1.96E-4 ID:SGTC_2916|Compound:7875993|FD-Score:4.16|P-value:1.19E-6 ID:SGTC_3066|Compound:9117245|FD-Score:2.89|P-value:5.21E-4 ID:SGTC_3067|Compound:9117431|FD-Score:2.78|P-value:7.86E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.15|P-value:2.14E-4 ID:SGTC_3098|Compound:9119039|FD-Score:2.85|P-value:5.92E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.04|P-value:2.78E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.11|P-value:2.52E-4 ID:SGTC_3251|Compound:9135047|FD-Score:-3.40|P-value:7.12E-5 ID:SGTC_3335|Compound:9143315|FD-Score:2.79|P-value:7.53E-4

Top fitness defect scores for YMR023C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2889 9059656 5.22 52.0 µM 1.74E-9 1 9.12E-8
2 SGTC_1914 st062367 4.80 72.6 µM 2.66E-8 8 7.87E-7
3 SGTC_2916 7875993 4.16 68.8 µM 1.19E-6 21 1.58E-5
4 SGTC_49 0717-0965 4.12 32.1 µM 1.50E-6 60S ribosome export 18 1.89E-5
5 SGTC_1744 st037937 3.74 38.9 µM 1.08E-5 36 9.06E-5
6 SGTC_645 0845-0943 3.70 5.4 µM 1.34E-5 60S ribosome export 14 1.07E-4
7 SGTC_2791 5663188 3.63 71.4 µM 1.92E-5 RPP1 & pyrimidine depletion 33 1.43E-4
8 SGTC_2851 9015922 3.48 71.4 µM 3.98E-5 64 2.54E-4
9 SGTC_1983 st071813 3.43 46.9 µM 4.91E-5 RPP1 & pyrimidine depletion 37 3.00E-4
10 SGTC_52 0329-0193 3.43 875.0 nM 5.03E-5 TSC3-RPN4 55 3.06E-4
11 SGTC_865 0488-0499 3.42 301.0 µM 5.29E-5 32 3.18E-4
12 SGTC_898 1000-0849 3.37 28.3 µM 6.38E-5 13 3.69E-4
13 SGTC_2398 5228213 3.36 48.8 µM 6.83E-5 iron homeostasis 71 3.90E-4
14 SGTC_2006 4011487 3.35 200.0 µM 7.08E-5 endomembrane recycling 113 4.01E-4
15 SGTC_815 1582-0027 3.32 36.9 µM 8.01E-5 60 4.42E-4
16 SGTC_131 0141-0277 3.32 33.9 µM 8.05E-5 68 4.44E-4
17 SGTC_205 1486-1330 3.29 71.9 µM 9.58E-5 32 5.10E-4
18 SGTC_1589 2',5'-dimethoxyflavone 3.27 47.2 µM 1.01E-4 46 5.30E-4
19 SGTC_1514 1189-1591 3.22 158.0 µM 1.29E-4 76 6.47E-4
20 SGTC_1115 galangin 3.13 695.7 nM 1.92E-4 RPP1 & pyrimidine depletion 45 8.84E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 1.24E-13 YER053C PIC2 hom Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
0.112 6.53E-11 YDL180W_p YDL180W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.090 1.59E-7 YHL002W HSE1 hom Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
0.090 1.72E-7 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.088 3.01E-7 YFR046C CNN1 hom Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T
0.088 3.54E-7 YBR016W YBR016W hom Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication
0.085 7.21E-7 YMR240C CUS1 het Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p
0.084 1.03E-6 YGL198W YIP4 hom Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
0.083 1.58E-6 YHR086W NAM8 hom RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function
0.081 2.58E-6 YGL216W KIP3 hom Kinesin-related motor protein involved in mitotic spindle positioning
0.079 4.56E-6 YJL173C RFA3 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.078 5.50E-6 YHR006W STP2 hom Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication
0.077 8.27E-6 YOL079W_d YOL079W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.076 9.27E-6 YGL161C YIP5 hom Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
0.076 9.33E-6 YJR103W URA8 hom Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication